PET ex vivo Radiometabolite Laboratory (PERL)

The PET ex vivo Radiometabolite Laboratory (PERL) is a facility of the Stony Brook University PET Research Core. It is dedicated to the ex vivo analysis of blood and other tissue samples to support preclinical and clinical PET imaging at Stony Brook University. The laboratory has comprehensive facilities for radioanalytical chemistry.

The laboratory is directed by Professor Wenchao Qu, PhD.

The PET Research Core is directed by Professor Mark Slifstein PhD.

PET Research at Stony Brook University is directed by Professor Ramin Parsey, MD PhD, Della Pietra Family Chair of Biomedical Imaging.

Services provided
Baseline and post injection blood chemistry
Assay of whole blood, serum or plasma radioactivity
Ex vivo analysis of radiopharmaceuticals and their metabolites in both blood and tissue samples

PERL is a fully equipped laboratory adjacent to the PET/MRI imaging facility which is able to:

Perform basic blood chemistry on baseline blood samples

Perform basic blood chemistry on radioactive blood samples

Assay radioactivity in whole blood, serum or plasma

Analyze whole blood samples for free radiopharmaceutical fraction

Analyze serum samples for intact radiopharmaceutical and radiometabolites

Analyze other tissue samples for radiopharmaceutical and radiometabolites

These analyses are essential for the correct modeling of radiopharmaceutical uptake and retention.