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Research interests
Eating, like art, is an organized activity that requires the coordination of sensory, motor, physiological, affective and cognitive processes. Understanding eating implies studying how neural circuits learn to integrate these processes and relate to behavior. Our lab takes this perspective in studying the insular cortex (aka gustatory cortex) and other subcortical areas classically believed to be involved in taste and reward. We study these circuits in rats and mice. We identify food-related behaviors that require decisions, anticipations and perception and study the role of the insular cortex in mediating them. We use behavioral training, electrophysiology (multielectrode recordings and intracellular physiology), optical imaging (2photon calcium imaging), pharmacology, molecular tools, anatomy and computational methods.
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Collaborations and top research areas from the last five years
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Discrimination Learning and Neural Dynamics in Gustatory Cortical Circuits
Fontanini, A. (PI), La Camera, G. (CoPI) & Wang, S. (CoPI)
National Inst on Deafness & Other Comm Disorders
02/2/26 → 01/31/27
Project: Research
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Cortical Circuits and Neurotransmitters for Taste Aversion Learning
Maffei, A. (PI) & Fontanini, A. (CoPI)
National Inst on Deafness & Other Comm Disorders
09/18/25 → 06/30/27
Project: Research
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Functional role of Gastrin Releasing Peptide (GRP) and GRP expressing neurons in the gustatory cortex
Fontanini, A. (PI) & Maffei, A. (CoPI)
National Inst on Deafness & Other Comm Disorders
06/9/23 → 05/31/27
Project: Research
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Thomas Hartman Center for Parkinson's Research
Fontanini, A. (PI), Bowen, M. E. (CoI), Collins III, W. (CoI), Colognato, H. (CoI), Hu, C.-K. (CoI), Kritzer, M. (CoI), Lamberg, E. M. (CoI), Leung, H. C. (CoI), Maffei, A. (CoI), Maurer, C. (CoI), Muratori, L. M. (CoI), Neiman, A. (CoI), Plotkin, J. (CoI), Puopolo, M. (CoI), Riessland, M. (CoI), Schwartz, G. (CoI), Shelly, M. (CoI), Sher, R. (CoI), Shrestha, P. (CoI), Sirotkin, H. I. (CoI), Solomon, I. C. (CoI), Thomsen IV, G. H. (CoI), Wollmuth, L. (CoI), Wu, S. (CoI), Xiong, Q. (CoI), Role, L. (PI), Christodoulou, C. (CoI), Evinger, L. (CoI), Halegoua, S. (CoI), Huang, C. (CoI), Levine, J. (CoI), Lutterbie, J. (CoI), Manganas, L. (CoI), Matthews, G. (CoI), Park, I. M. (CoI) & Talmage, D. (CoI)
04/15/13 → 08/31/27
Project: Research
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Cortical dopaminergic signaling mediates planning of directional movements
Chen, J. & Fontanini, A., 2025, In: Science Advances. 11, 48, eadt2730.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Deficits in taste-guided behaviors and central processing of taste in the transgenic TDP-43Q331K mouse model of frontotemporal dementia
Zheng, C. Y., Blackwell, J. M. & Fontanini, A., Apr 2025, In: Neurobiology of Disease. 207, 106850.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Modulation of sweet preference by neurosteroid-sensitive, δ-GABAA receptors in adult mouse gustatory insular cortex
Yevoo, P. E., Fontanini, A. & Maffei, A., Mar 10 2025, In: Current Biology. 35, 5, p. 1047-1060.e4Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Learning enhances representations of taste-guided decisions in the mouse gustatory insular cortex
Kogan, J. F. & Fontanini, A., May 6 2024, In: Current Biology. 34, 9, p. 1880-1892.e5Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Experience-dependent plasticity of gustatory insular cortex circuits and taste preferences
Schiff, H. C., Kogan, J. F., Isaac, M., Czarnecki, L. A., Fontanini, A. & Maffei, A., Jan 2023, In: Science Advances. 9, 2, eade6561.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations