Grants & Projects per year
Personal profile
Research interests
Understanding how defects in glycosylation lead to birth defects
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Dive into the research topics where Bernadette Holdener is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Grants & Projects
- 11 Finished
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Role of POGLUT2 and POGLUT3 in Regulating Microfibril Structure and Function (R01-MPI-Holdener)
Holdener, B. (PI)
National Heart Lung and Blood Institute
07/1/22 → 06/30/26
Project: Research
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2019 Innovator Award: How Does Loss of Glucose on TSRs Cause Hydrocephalus
Holdener, B. (PI)
12/1/19 → 07/31/21
Project: Research
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Role of Beta3-Glucosyltransferase in a Non-Canonical Quality Control Pathway
Holdener, B. (PI)
Eunice Kennedy Shriver National Institute of Child Health & Human Dev
09/17/18 → 06/30/24
Project: Research
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O-Glycosylation of Epidermal Growth Factor-like Motifs
Holdener, B. (CoPI) & Haltiwanger, R. (PI)
National Institute of General Medical Sciences
05/1/16 → 06/30/18
Project: Research
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Loss of POGLUT2/3-mediated O-glucosylation produces lung and aortic phenotypes reminiscent of fibrillin1 mutants
Neupane, S., Almiroudis, A., Donnelly, K. E., Haltiwanger, R. S. & Holdener, B. C., 2026, (Accepted/In press) In: Developmental Dynamics.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
POGLUT2 and POGLUT3: Two essential protein O-glucosyltransferases modifying EGF repeats in extracellular matrix proteins
Kegley, N. R., Holdener, B. C. & Haltiwanger, R. S., Jun 2026, In: BBA - General Subjects. 1870, 6, 130942.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
POGLUT2/3 mediated EGF O-glucosylation promotes separation of digits 2 and 3 by influencing fibrillin network reorganization, signaling, and cell dynamics
Neupane, S., Janowicz, I. A., Godwin, A. R. F., Donnelly, K. E., Grady, R. C., Haltiwanger, R. S., Baldock, C. & Holdener, B. C., Nov 2025, In: Developmental Biology. 527, p. 147-164 18 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues
Neupane, S., Williamson, D. B., Roth, R. A., Halabi, C. M., Haltiwanger, R. S. & Holdener, B. C., Jul 2024, In: Journal of Biological Chemistry. 300, 7, 107445.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
O-fucosylation of thrombospondin type I repeats is dispensable for trafficking thrombospondin 1 to platelet secretory granules
Berardinelli, S. J., Sillato, A. R., Grady, R. C., Neupane, S., Ito, A., Haltiwanger, R. S. & Holdener, B. C., Apr 1 2023, In: Glycobiology. 33, 4, p. 301-310 10 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations