Grants & Projects per year
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Research interests
Dr. DeLorenzo’s research advances precision medicine, applying advanced neuroimaging to uncover the biological bases of mood disorders and neurological diseases. Using positron-emission tomography (PET) and magnetic resonance imaging (MRI), her team examines living human brains—both in health and in disease—to quantify key neurobiological systems including neurotransmitter activity, inflammation, and brain metabolism that shape emotional and cognitive health.
Her broader program focuses on developing brain-based biomarkers to improve diagnosis and predict individual response to treatments. To accomplish this, she integrates neuroimaging with physiological and behavioral measures to better understand and treat diseases such as depression and Alzheimer’s disease.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Preliminary Imaging Study of Neuroinflammation as a Treatment Strategy for Depression in ASD
Gadow, K. (PI), DeLorenzo, C. (CoPI) & Parsey, R. V. (CoPI)
National Institute of Mental Health
09/1/26 → 08/31/28
Project: Research
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Quantifying the Mechanism of Transcranial Magnetic Stimulation in Depression: A Preliminary Positron Emission Tomography Study of Microglia
Parsey, R. V. (PI) & DeLorenzo, C. (CoPI)
National Institute of Mental Health
07/1/26 → 06/30/28
Project: Research
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The Utility of Cyclooxygenase-1 PET Imaging as a Novel Neuroinflammatory Biomarker for Alzheimer's Disease
Kim, M. J. (PI), DeLorenzo, C. (CoPI), Parsey, R. V. (CoPI), Yang, J. (CoPI), Christodoulou, C. (CoI) & Oliva, C. (CoI)
03/15/26 → 02/28/27
Project: Research
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Mechanistic Clinical Trial Evaluating the Role of the Metabotropic Glutamate Receptor Subtype 5 (mGluR5) in the Antidepressant Mechanism of Cognitive Behavioral Therapy for Insomnia (CBT-I)
DeLorenzo, C. (PI), Parsey, R. V. (CoPI), Rozensky, R. E. (CoPI) & Yang, J. (CoPI)
National Institute of Mental Health
05/1/25 → 03/31/27
Project: Research
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Center for Healthy Aging Pilot Program
Igarashi, P. (PI), DeLorenzo, C. (CoPI), Fields, S. (CoPI), Acosta, M. (CoI), Colognato, H. (CoI), Enikolopov, G. (CoI), Heslin, S. M. (CoI), Hu, C.-K. (CoI), Kaczocha, M. (CoI), Kim, H. (CoI), Kim, M. J. (CoI), Kumar, P. (CoI), Mackow, E. (CoI), Mathew, J. (CoI), Nadkarni, N. (CoI), Parker, M. (CoI), Rajupet, S. (CoI), Reich Marshall, N. C. (CoI), Riessland, M. (CoI), Rozensky, R. E. (CoI), Sher, R. (CoI), Sheridan, B. (CoI), Singer, A. (CoI), Sunar, U. (CoI), Tsirka, S. E. (CoI), Vorkas, C. K. (CoI), Wang, J. (CoI), Xiong, Q. (CoI) & Ye, F. (CoI)
08/1/23 → 12/31/27
Project: Research
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Fatigue in major depression is linked to depression severity, not sleep duration or anterior cingulate cortex neurochemistry
Batheja, S., Yang, J., Liao, Y., Wengler, K., He, X., Ali, F. Z., Rozensky, R. & DeLorenzo, C., Apr 15 2026, In: Journal of Affective Disorders. 399, 121076.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Obesity-related differences in amygdala and hippocampal volume and metabolism before and after a placebo-controlled antidepressant trial in major depressive disorder
Lin, K., Hasegawa, K., Rapelli, V., Yang, J., Parsey, R. V. & DeLorenzo, C., Dec 2026, In: Scientific Reports. 16, 1, 10979.Research output: Contribution to journal › Article › peer-review
Open Access -
A central role for acetylcholine in entorhinal cortex function and dysfunction with age in humans and mice
Ananth, M. R., Gardus, J. D., Huang, C., Palekar, N., Slifstein, M., Zaborszky, L., Parsey, R. V., Talmage, D. A., DeLorenzo, C. & Role, L. W., Feb 25 2025, In: Cell Reports. 44, 2, 115249.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Connecting the dots: approaching a standardized nomenclature for molecular connectivity in positron emission tomography
Reed, M. B., Cocchi, L., Sander, C. Y., Chen, J., Matheson, G. J., Fisher, P., Volpi, T., Khattar, N., DeLorenzo, C., Gryglewski, G., Silberbauer, L. R., Murgaš, M., Godbersen, G. M., Nics, L., Walter, M., Hacker, M., Bertoldo, A., Lubberink, M., Silfstein, M. & Ogden, R. T. & 13 others, , Dec 2025, In: European Journal of Nuclear Medicine and Molecular Imaging. 53, 1, p. 48-58 11 p.Research output: Contribution to journal › Review article › peer-review
Open Access9 Scopus citations -
Glial activation among individuals with neurological post-acute sequelae of coronavirus disease 2019: A positron emission tomography study of brain fog using [18F]-FEPPA
Clouston, S. A. P., Vaska, P., Babalola, T., Gardus, J., Huang, C., Soriolo, N., Fontana, A., DeLorenzo, C., Parsey, R. & Luft, B. J., Mar 2025, In: Brain, Behavior, and Immunity - Health. 44, 100945.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations