Grants & Projects per year
Personal profile
Research interests
The focus of the Biofluids Research Group is the study of the dynamics of blood flow and cellular transport in the cardiovascular system, with an emphasis on flow-induced mechanisms underlying cardiovascular disease processes and their progression. Pathological flow fields that arise as a result of cardiovascular diseases or prosthetic devices have a complex interaction with blood vessels and blood itself. Over the last decade, evidence has accumulated indicating that local flow-induced stresses alter the molecular mechanisms of the formed elements of blood, and have a major effect on blood clotting. The end result can be thrombus formation that can occlude arteries, or handicap the functionality of implanted devices such as ventricular assist devices (VADs), total artificial hearts (TAH), and prosthetic heart valves.
Biography
Danny Bluestein, Ph.D. is a SUNY Distinguished Professor- a Professor of Biomedical Engineering at Stony Brook University, NY. He received his bachelor degree in Aeronautical Engineering from the Technion, Israel Institute of Technology, and Ph.D. in biomedical Engineering at Tel Aviv University, Israel. His research interests include the elucidation of physical forces that regulate cellular function in flowing blood, and translation of this knowledge to numerical and experimental strategies aimed at improving the design of blood recirculating devices such as prosthetic heart valves, ventricular assist devices and the total artificial heart, developing multiscale modeling approaches to describe blood clotting, and enhancing clinical diagnostics of cardiovascular diseases by using patient based numerical simulations. He has published 160 peer reviewed papers and book chapters. He served as an associate editor of the ASME Journal of Medical Devices and currently as associate editor of Frontiers Bioengineering, and of Bioengineering J. He is a member of the editorial board and an associate editor in leading bioengineering journals. He is an active member in the Biomedical Engineering Society, Bioengineering Division of the American Society for Mechanical Engineers where he served as the elected chair of the BED Biofluids technical committee. He is a member of the National Institutes of Health (NIH) Steering Committee of the Multiscale Modeling (MSM) Consortium, the Dassault Systèmes Simulia Living Heart Project, and the International Hemodynamic Society. Prof. Bluestein has received several major honors and awards including the Established Investigator Award from the American Heart Association (AHA) and the Quantum award from the NIH-NIBIB. He was elected as a Fellow of the Biomedical Engineering Society (BMES), a Fellow of the American Institute of Medical and Biological Engineering (AIMBE), and a member of the National Academy of Inventors. He is the recipient of the 2021 ASME Savio L-Y Woo Translational Biomechanics Medal. He collaborates with several medical devices corporations and with leading CFD/FEA companies, and founded the Polynova Cardiovascular Inc. startup company. His research has been sponsored by various federal agencies and private foundations including the National Institutes of Health, the National Science Foundation, and the American Heart Association.
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Collaborations and top research areas from the last five years
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Funds from Stony Brook Foundation to fund Mini Grants. REACH
Rubin, C. (PI), Brouzes, E. (CoI), Carter, C. (CoI), Chan, M. L. (CoI), Coutsias, E. (CoI), Del Poeta, M. (CoI), Frohman, M. (CoI), Haley, J. D. (CoI), Hearing, P. (CoI), Ju, J. (CoI), Kaufman, A. (CoI), Kozakov, D. (CoI), Lin, W. (CoI), Ojima, I. (CoI), Panesar, R. S. (CoI), Pisconti, D. (CoI), Powers, R. S. (CoI), Qin, Y.-X. (CoI), Sampson, N. (CoI), Seeliger, J. (CoI), Serebryany, E. (CoI), Spaniolas, K. (CoI), Strey, H. H. (CoI), Sunar, U. (CoI), Thanassi, D. G. (CoI), Tonge, P. (CoI), Zhang, Y. (CoI), Zhao, W. (CoI), Fabel, D. (CoPI), Alaei, S. (CoI), Bates, A. (CoI), Boros, E. (CoI), Daryaee, F. (CoI), Docimo, S. (CoI), Girnun, G. (CoI), Goldan, A. (CoI), Levy, S. (CoI), Philip, F. (CoI), Pryor, A. D. (CoI), Yang, X. (CoI), Bluestein, D. (CoI), Rafailovich, M. (CoI), Singh, G. (CoI), Fu, S. (CoI) & Josephs, E. (CoI)
12/20/15 → 06/30/27
Project: Research
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Biomechanical Approaches and Technologies for Enhancing TAVR Outcomes
Bluestein, D. (PI) & Haj-Ali, R. (CoPI)
National Institute of Biomedical Imaging and Bioengineering
06/1/22 → 12/31/24
Project: Research
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Biomechanical Approaches and Technologies for Enhancing TAVR Outcomes
Bluestein, D. (PI) & Haj-Ali, R. (CoPI)
National Institute of Biomedical Imaging and Bioengineering
06/1/21 → 05/31/22
Project: Research
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STTR/SBIR: Phase 2: A Novel Polymeric Valve for Transcatheter Aortic Valve Replacement
Bluestein, D. (PI)
National Heart Lung and Blood Institute
08/1/20 → 02/28/26
Project: Research
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Center for Biotechnology 2020 - 2025
Rubin, C. (PI), Bahar, I. (CoI), Bluestein, D. (CoI), Lin, W. (CoI), Pentyala, S. (CoI), Qin, Y.-X. (CoI) & Strey, H. H. (CoI)
NYS Department of Economic Development
07/1/20 → 12/31/25
Project: Research
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Development of a Polymeric TAVR Device Tailored to Bicuspid Aortic Valve Patients Using In Silico Design Optimization and Evaluation
Baylous, K., Helbock, R., Kovarovic, B., Slepian, M. J. & Bluestein, D., Feb 2026, In: Annals of Biomedical Engineering. 54, 2, p. 436-451 16 p.Research output: Contribution to journal › Article › peer-review
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Impact of aortic valve leaflets calcium volume and distribution on Post-TAVR conduction abnormalities
Reza, S., Kovarovic, B. & Bluestein, D., Oct 2026, In: Computer Methods and Programs in Biomedicine. 285, 109543.Research output: Contribution to journal › Article › peer-review
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In Vitro Biomechanical Examination of Excised Calcified Aortic Leaflet Tissue for Material Property Assessment and Improved In Silico Modeling
Baylous, K., Anam, S., Kovarovic, B., Parikh, P. B., Price, J., Yammine, M., McLarty, A., Slepian, M. & Bluestein, D., Sep 2026, In: Biomedical Materials and Devices. 4, 3, p. 3336-3354 19 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
The Effect of von Willebrand Disease on Platelet Adhesion Dynamics: Correlating a Multiscale Platelet Model to in Vitro Results
Wang, P., Sheriff, J., Deng, Y. & Bluestein, D., May 1 2026, In: IEEE Transactions on Biomedical Engineering. 73, 5, p. 2021-2028 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The Reverse Calcification Technique (RCT): A Quantitative Parametric Model of Aortic Stenosis Progression
Sharon, M., Tal, O., Hamdan, A., Morany, A., Bluestein, D. & Haj-Ali, R., 2026, (Accepted/In press) In: Cardiovascular Engineering and Technology.Research output: Contribution to journal › Article › peer-review
Open Access