Grants & Projects per year
Personal profile
Research interests
Dr. Speer conducts laboratory and clinical research to better understand how infections in newborns can lead to injury of the brain, kidney, and other organs
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Dive into the research topics where Esther Speer is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Immunomodulatory Therapy to Improve Outcomes of Neonatal Sepsis
Speer, E. (PI), Fries, B. (CoPI) & Tonge, P. (CoPI)
National Institute of Allergy & Infectious Disease
03/6/20 → 02/28/23
Project: Research
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Little Angel Fund Gift - Pharmacological Strategies to Enhance the Neonatal Anti-Inflammatory Defense
Speer, E. (PI), Maduekwe, E. (CoPI), Parekh, A. (CoPI) & Sridhar, S. (CoPI)
Little Angel Fund Incorporated
04/23/15 → 06/30/16
Project: Research
Research output
- 9 Article
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A graded neonatal mouse model of necrotizing enterocolitis demonstrates that mild enterocolitis is sufficient to activate microglia and increase cerebral cytokine expression
Sha, C., Van Brunt, T., Kudria, J., Schmidt, D., Yurovsky, A., Bandovic, J., Giarrizzo, M., Lin, J., Tsirka, S. A., Bialkowska, A. B., Wollmuth, L. P., Speer, E. M. & Hsieh, H., May 2025, In: PLoS ONE. 20, 5 May, e0323626.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Attenuation of acute kidney injury in a murine model of neonatal Escherichia coli sepsis
Speer, E. M., Adedeji, A. A., Lin, J., Khorasanchi, A., Rasheed, A., Bhat, M., Mackenzie, K., Hennigar, R., Reidy, K. J. & Woroniecki, R. P., 2024, In: Frontiers in Cellular and Infection Microbiology. 14, 1507914.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
The state and future of pediatric research—an introductory overview: The state and future of pediatric research series
Speer, E. M., Lee, L. K., Bourgeois, F. T., Gitterman, D., Hay, W. W., Davis, J. M. & Javier, J. R., 2023, (Accepted/In press) In: Pediatric Research.Research output: Contribution to journal › Article › peer-review
Open Access52 Scopus citations -
A Neonatal Murine Escherichia coli Sepsis Model Demonstrates That Adjunctive Pentoxifylline Enhances the Ratio of Anti- vs. Pro-inflammatory Cytokines in Blood and Organ Tissues
Speer, E. M., Diago-Navarro, E., Ozog, L. S., Raheel, M., Levy, O. & Fries, B. C., Sep 23 2020, In: Frontiers in Immunology. 11, 577878.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro
Speer, E. M., Dowling, D. J., Xu, J., Ozog, L. S., Mathew, J. A., Chander, A., Yin, D. & Levy, O., May 2018, In: PLoS ONE. 13, 5, e0196352.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations