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Jae Ho Lee

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Jae Ho Lee

 https://orcid.org/0000-0002-8663-3209
    20152026

    Research activity per year

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    Research interests

    Our lab is broadly interested in understanding how proteins mature as they are made on the ribosome.  In particular, we are investigating how the speed of ribosome translation impacts the biogenesis and homeostasis of nascent proteins (Co-translational Proteostasis). Recent work has shown that this aspect is one of the major contributors to different phenotypes of aging (Hallmarks of Aging) in multiple organisms. We integrate bioinformatics and biochemical/biophysical techniques to discover and validate novel mechanisms that ensure proper maturation of nascent proteins and how they get impaired during aging.

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    • NAC controls nascent chain fate through tunnel sensing and chaperone action

      Lee, J. H., Rabl, L., Gamerdinger, M., Goyal, V., Khakzar, K. M., Barbosa, N. M., Abramovich, J., Morales-Polanco, F., Köhler, A. K., Samatova, E., Rodnina, M. V., Deuerling, E. & Frydman, J., Apr 2 2026, In: Nature. 652, 8108, p. 230-239 10 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      4 Scopus citations

    • Altered translation elongation contributes to key hallmarks of aging in the killifish brain

      Di Fraia, D., Marino, A., Lee, J. H., Sacramento, E. K., Baumgart, M., Bagnoli, S., Balla, T., Schalk, F., Kamrad, S., Guan, R., Caterino, C., Giannuzzi, C., da Silva, P. T., Sahu, A. K., Gut, H., Siano, G., Tiessen, M., Terzibasi-Tozzini, E., Fornasiero, E. F. & Gagneur, J. & 7 others, Englert, C., Patil, K. R., Correia-Melo, C., Nedialkova, D. D., Frydman, J., Cellerino, A. & Ori, A., Jul 31 2025, In: Science. 389, 6759, eadk3079.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      26 Scopus citations

    • Mechanistic Insights into Protein Biogenesis and Maturation on the Ribosome

      Lentzsch, A. M., Lee, J. H. & Shan, S. O., 2025, (Accepted/In press) In: Journal of Molecular Biology. 169056.

      Research output: Contribution to journal › Review article › peer-review

      Open Access
      4 Scopus citations

    • Cotranslational Mechanisms of Protein Biogenesis and Complex Assembly in Eukaryotes

      Morales-Polanco, F., Lee, J. H., Barbosa, N. M. & Frydman, J., Aug 10 2022, In: Annual Review of Biomedical Data Science. 5, p. 67-94 28 p.

      Research output: Contribution to journal › Review article › peer-review

      Open Access
      46 Scopus citations

    • Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER

      Lee, J. H., Jomaa, A., Chung, S. Y., Fu, Y. H. H., Qian, R., Sun, X., Hsieh, H. H., Chandrasekar, S., Bi, X., Mattei, S., Boehringer, D., Weiss, S., Ban, N. & Shan, S. O., May 2021, In: Science Advances. 7, 21, eabg0942.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      25 Scopus citations
    View all 10 Research outputs