Personal profile
Research interests
Dr. Ju’s research at Renaissance School of Medicine at Stony Brook University focuses on elucidating the mechanism of translational control mediated by non-coding RNAs in cancer and translating the new discovery to clinical cancer diagnosis and therapy. His group is the first to discover that p53 regulates the expression of certain miRNAs, opening a new frontier in cancer research. Dr. Ju’s group is actively investigating the mechanism of miRNAs in proliferation, cell cycle control, chemoresistance to fluoropyrimidines and antifolates in tumor stem cells, and epithelial-to-mesenchymal transition. His group is also developing novel approaches to study post-transcriptional control mediated by miRNAs and RNA binding proteins. As for the translational research, they are interested in the investigation of miRNAs as biomarkers in cancer diagnosis and prognosis.
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Collaborations and top research areas from the last five years
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VA Assignment to Provide Salary Support to Amartya Pal 24-26
Ju, J. (PI)
Veterans Administration Medical Ctr at Northport
07/1/24 → 06/30/26
Project: Research
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VA IPA for Anushka Ojha 24-26
Ju, J. (PI)
Veterans Administration Medical Ctr at Northport
07/1/24 → 06/30/26
Project: Research
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Funds from Stony Brook Foundation to fund Mini Grants. REACH
Rubin, C. (PI), Brouzes, E. (CoI), Carter, C. (CoI), Chan, M. L. (CoI), Coutsias, E. (CoI), Del Poeta, M. (CoI), Frohman, M. (CoI), Haley, J. (CoI), Hearing, P. (CoI), Ju, J. (CoI), Kaufman, A. (CoI), Kozakov, D. (CoI), Lin, W. (CoI), Ojima, I. (CoI), Panesar, R. (CoI), Pisconti, A. (CoI), Powers, R. (CoI), Qin, Y.-X. (CoI), Sampson, N. (CoI), Seeliger, J. (CoI), Serebryany, E. (CoI), Spaniolas, K. (CoI), Strey, H. (CoI), Sunar, U. (CoI), Thanassi, D. (CoI), Tonge, P. (CoI), Zhang, Y. (CoI), Zhao, W. (CoI), Fabel, D. (CoPI), Alaei, S. (CoI), Bates, A. (CoI), Boros, E. (CoI), Daryaee, F. (CoI), Docimo, S. (CoI), Girnun, G. (CoI), Goldan, A. (CoI), Levy, S. (CoI), Philip, F. (CoI), Pryor, A. D. (CoI), Yang, X. (CoI), Bluestein, D. (CoI), Rafailovich, M. (CoI), Singh, G. (CoI) & Fu, S. (CoI)
12/20/15 → 06/30/27
Project: Research
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IPA Agreement for Amartya Pal
Ju, J. (PI)
Veterans Administration Medical Ctr at Northport
07/1/23 → 06/30/24
Project: Research
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Challenges and opportunities in microRNA-based cancer therapeutics
Ju, J., Apr 15 2025, In: Cell Reports Medicine. 6, 4, 102057.Research output: Contribution to journal › Comment/debate
Open Access15 Scopus citations -
Correction to: Therapeutic Potential of Chemically Modified miR-489 in Triple-Negative Breast Cancers (Cancers, (2020), 12, 8, (2209), 10.3390/cancers12082209)
Soung, Y. H., Chung, H., Yan, C., Fesler, A., Kim, H., Oh, E. S., Ju, J. & Chung, J., Mar 2024, In: Cancers. 16, 5, 1010.Research output: Contribution to journal › Comment/debate
Open Access -
Development of gemcitabine-modified miRNA mimics as cancer therapeutics for pancreatic ductal adenocarcinoma
Yuen, J. G., Hwang, G. R., Fesler, A., Intriago, E., Pal, A., Ojha, A. & Ju, J., Mar 21 2024, In: Molecular Therapy Oncology. 32, 1, 200769.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Development of novel 5-FU modified siRNA against BCL-2 with enhanced efficacy and vehicle-free cellular uptake
Fesler, A., Hwang, G. R. & Ju, J., Jan 2024, In: Genes and Diseases. 11, 1, p. 23-25 3 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The Sensitization of Triple-Negative Breast Cancers to Poly ADP Ribose Polymerase Inhibition Independent of BRCA1/2 Mutation Status by Chemically Modified microRNA-489
Soung, Y. H., Ju, J. & Chung, J., Jan 2024, In: Cells. 13, 1, 49.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations