Grants & Projects per year
Personal profile
Research interests
Lens membrane proteins and gap junctions.
Our research focuses on the physiology and pharmacology of mammalian lens membrane transporters, with specific emphasis on aquaporins, glucose transporters, and Vitamin C transporters and their relation to lens cataract and transparency.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Roles of Lens Aquaporins and GPX1 in Hydrogen Peroxide Balance, Homeostasis, and Aging
Varadaraj, K. (PI), Kumari, S. (CoPI) & Mathias, R. (CoPI)
09/1/22 → 08/31/27
Project: Research
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Terahertz Time-Domain Spectroscopic Imaging of Cornea for Three Dimensional Mapping of Hydration Gradients
Arbab, H. (PI), Chou, T. (CoPI), Honkanen, R. A. (CoPI), Taylor, G. (CoPI) & Varadaraj, K. (CoPI)
08/1/24 → 07/31/26
Project: Research
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Role of Aquaporins in Mammalian Lens Development, Transparency and Homeostasis
Varadaraj, K. (PI) & Kumari, S. (CoPI)
12/1/15 → 11/30/21
Project: Research
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Volume Regulation in Normal and Cataractous Lenses
Varadaraj, K. (CoPI) & Mathias, R. (PI)
09/1/10 → 08/31/16
Project: Research
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Role of Aquaporin-0 for Cell-to-Cell Adhesion and Lens Transparency
Varadaraj, K. (PI) & Kumari, S. (CoPI)
04/1/10 → 03/31/16
Project: Research
Research output
- 43 Article
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CatTohm mutation studies identify AQP0 as a modulator of lens transparency, cell-to-cell adhesion, biomechanics, microcirculation and homeostasis
Varadaraj, K., Gao, J., Mathias, R. T. & Kumari, S., Nov 2026, In: Experimental Eye Research. 272, 111207.Research output: Contribution to journal › Article › peer-review
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CD24 is required for sustained transparency of the adult lens
Shihan, M. H., Balasubramanian, R., Wang, Y., Rafi, R., Faranda, A. P., Parreno, J., Varadaraj, K., Gao, J., Mathias, R. T., Nie, X. & Duncan, M. K., Jun 2025, In: Experimental Eye Research. 255, 110347.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Functional characterization of CatTohm, a mouse AQP0 mutation that causes oxidative stress, cytotoxicity, dominant congenital lens cataract and microphthalmia
Kumari, S., Okamura, T. & Varadaraj, K., Aug 2025, In: Experimental Eye Research. 257, 110434.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Studies on Hydrostatic Pressure Responses to Piezo1 and TRPV4 in the Mouse Lens
Gao, J., Mathias, R. T., Varadaraj, K., Shahidullah, M., Mei, J. & Delamere, N. A., Oct 2025, In: Investigative Ophthalmology and Visual Science. 66, 13, 20.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Effect of hydrogen peroxide on lens transparency, intracellular pH, gap junction coupling, hydrostatic pressure and membrane water permeability
Varadaraj, K., Gao, J., Mathias, R. T. & Kumari, S., Aug 2024, In: Experimental Eye Research. 245, 109957.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations