Skip to main navigation Skip to search Skip to main content
Ledong Wan

View Scopus Profile

Ledong Wan

    20132026

    Research activity per year

    Personal profile

    Research interests

    RNA alternative splicing (AS) is a finely tuned process through which pre-messenger RNA (pre-mRNA) is processed into two or more mature RNA (mRNA) isoforms in the nucleus, contributing to proteome diversity and gene-expression regulation.Cancer cells often exhibit aberrant splicing profiles, leading to the production of isoforms that increase cell proliferation, migration, or resistance to apoptosis.

    Our laboratory seeks to understand the mechanisms by which RNA splicing is dysregulated to promote tumorigenesis and progression. We utilize transgenic mouse models and organoid culture to investigate the regulation of RNA splicing in physiological conditions and its dysregulation in inflammation and pancreatic cancer. Our expertise in small molecules and antisense technology enables us to modulate aberrant splicing in order to develop promising drugs for cancer therapy.

    Fingerprint

    Dive into the research topics where Ledong Wan is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
    • 1 Similar Profiles
    View full fingerprint

    Collaborations and top research areas from the last five years

    Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
    Explore network further

    • Splice-switching ASOs targeting the AURKA 5′ UTR collapse an SRSF1-AURKA-MYC oncogenic circuit in pancreatic cancer

      Kral, A. J., Jia, L., Sim, G. Y., Wan, L., Ishigami, Y. & Krainer, A. R., Jan 8 2026, In: Molecular Cell. 86, 1, p. 60-77.e7

      Research output: Contribution to journal › Article › peer-review

      Open Access
      4 Scopus citations

    • Transcriptomic regulation of pancreatic acinar cell homeostasis and plasticity

      Zhang, X., Luo, C., Coughlin, K., Li, F. Q., Takemaru, K. I. & Wan, L., Jun 2026, In: Biochemical Society transactions. 54, 6, p. 681-697 17 p.

      Research output: Contribution to journal › Review article › peer-review

      Open Access

    • Splicing factor RBM10 loss fuels thyroid cancer metastasis

      Coughlin, K. & Wan, L., May 5 2025, In: Journal of Experimental Medicine. 222, 5

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment

      He, X. Y., Gao, Y., Ng, D., Michalopoulou, E., George, S., Adrover, J. M., Sun, L., Albrengues, J., Daßler-Plenker, J., Han, X., Wan, L., Wu, X. S., Shui, L. S., Huang, Y. H., Liu, B., Su, C., Spector, D. L., Vakoc, C. R., Van Aelst, L. & Egeblad, M., Mar 11 2024, In: Cancer Cell. 42, 3, p. 474-486.e12

      Research output: Contribution to journal › Article › peer-review

      Open Access
      266 Scopus citations

    • Interaction between MED12 and ΔNp63 activates basal identity in pancreatic ductal adenocarcinoma

      Maia-Silva, D., Cunniff, P. J., Schier, A. C., Skopelitis, D., Trousdell, M. C., Moresco, P., Gao, Y., Kechejian, V., He, X. Y., Sahin, Y., Wan, L., Alpsoy, A., Liverpool, J., Krainer, A. R., Egeblad, M., Spector, D. L., Fearon, D. T., dos Santos, C. O., Taatjes, D. J. & Vakoc, C. R., Jul 2024, In: Nature Genetics. 56, 7, p. 1377-1385 9 p.

      Research output: Contribution to journal › Letter › peer-review

      Open Access
      14 Scopus citations
    View all 21 Research outputs