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Research interests
Our laboratory seeks to understand the complex molecular and cellular events that establish neuronal morphology and function during embryonic development. An early and essential event in mammalian embryonic brain development is neuronal polarization, in which distinct axonal and dendritic compartments are formed. Axons and dendrites differ in the molecular compositions of their cytoplasm, cytoskeleton, and plasma membrane. These differences underlie the unique morphology and function of these compartments, and are responsible for the directed information flow in the brain. Aberrations in neuron polarization lead to developmental neuropathologies, including intellectual and motor disabilities, epilepsy, and autism spectrum disorders. Our lab seeks to understand the molecular mechanisms for the critical events in neuronal polarization during normal development and in disease pathologies.
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Collaborations and top research areas from the last five years
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Research Seed Grant Program
Agrawal, S. (CoI), Boon, E. (CoI), Chakraborty, N. (CoI), Chen, J. (CoI), Citovsky, V. (CoI), Feinberg, E. (CoI), Fries, B. (CoI), Hamideh, S. (CoI), Henkes, G. A. (CoI), Talos, F. M. (CoI), Kim, H. (CoI), Leung, H. C. (CoI), Mofakham, S. (CoI), Mueller, K. (CoI), Pisconti, D. (CoI), Salman, E. (CoI), Shelly, M. (CoI), Sirotkin, H. I. (CoI), Almas, B. (PI), Iacabucci, J. (PI), Aga, D. (CoI), Alexander, J. (CoI), Atilla-Gokcumen, G. (CoI), Beverley, J. (CoI), Boivin, B. (CoI), Brooks, T. (CoI), Callahan, B. (CoI), Cavuoto, L. (CoI), Chen, H.-Y. (CoI), Choi, S. (CoI), Cook, T. (CoI), Downs, C. (CoI), Elias Arriaga, A. L. (CoI), Faghihi, D. (CoI), Feldblyum, J. (CoI), Ferkey, D. (CoI), Ford Versypt, A. (CoI), Gokcumen, O. (CoI), Guo, H. (CoI), Halterman, M. (CoI), Halterman, M. (CoI), Huang, R. (CoI), Jarvis, J. (CoI), Ke, C. (CoI), Lacy, D. (CoI), Lao, Y.-H. S. (CoI), Lapenis, A. (CoI), Lee, J. U. (CoI), Leighton, G. (CoI), Liu, H. (CoI), Liu, X. (CoI), Loh, S. (CoI), Luo, J. (CoI), Meyer, P. (CoI), Ning, F. (CoI), Oktyabrsky, S. (CoI), Orom, H. (CoI), Park, J. (CoI), Paul, M. (CoI), Razavi Aghjeh, M. J. (CoI), Scimemi, A. (CoI), Shin, D. (CoI), Shin, S. (CoI), Siegel, P. (CoI), Sisto, S. A. (CoI), Smith, B. (CoI), Subryan, H. (CoI), Sun, Y. (CoI), Tripp, J. (CoI), Tumey, L. N. (CoI), Wang, Y. (CoI), Watson, D. (CoI), Xu, W. (CoI) & Zhou, C. (CoI)
04/1/22 → 03/31/27
Project: Research
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Thomas Hartman Center for Parkinson's Research
Fontanini, A. (PI), Bowen, M. E. (CoI), Collins III, W. (CoI), Colognato, H. (CoI), Hu, C.-K. (CoI), Kritzer, M. (CoI), Lamberg, E. M. (CoI), Leung, H. C. (CoI), Maffei, A. (CoI), Maurer, C. (CoI), Muratori, L. M. (CoI), Neiman, A. (CoI), Plotkin, J. (CoI), Puopolo, M. (CoI), Riessland, M. (CoI), Schwartz, G. (CoI), Shelly, M. (CoI), Sher, R. (CoI), Shrestha, P. (CoI), Sirotkin, H. I. (CoI), Solomon, I. C. (CoI), Thomsen IV, G. H. (CoI), Wollmuth, L. (CoI), Wu, S. (CoI), Xiong, Q. (CoI), Role, L. (PI), Christodoulou, C. (CoI), Evinger, L. (CoI), Halegoua, S. (CoI), Huang, C. (CoI), Levine, J. (CoI), Lutterbie, J. (CoI), Manganas, L. (CoI), Matthews, G. (CoI), Park, I. M. (CoI) & Talmage, D. (CoI)
04/15/13 → 08/31/27
Project: Research
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Molecular Mechanisms that Initiate Apical Dendrite Development During Embryonic Neuronal Development
Shelly, M. (PI)
National Inst of Neurological Disorders & Stroke
06/15/21 → 11/30/25
Project: Research
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Controlling Spatially Restricted Intracellular Protein-Activity During Embryonic Neuronal Development Using Biomagnetic Nanotechnologies
Shelly, M. (PI), Stanacevic, M. (CoPI) & Wong, S. S. (CoPI)
National Inst of Neurological Disorders & Stroke
12/15/20 → 11/30/24
Project: Research
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Probing the optical properties and toxicological profile of zinc tungstate nanorods
Fang, J., Hurley, N., Chien, C. T., Guo, A., Khan, T. A., Li, M., Cotlet, M., Moretti, F., Bourret, E., Shifman, S., Tsirka, S. E., Shelly, M. & Wong, S. S., Jun 21 2024, In: Journal of Chemical Physics. 160, 23, 234701.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Immunoproximity biotinylation reveals the axon initial segment proteome
Zhang, W., Fu, Y., Peng, L., Ogawa, Y., Ding, X., Rasband, A., Zhou, X., Shelly, M., Rasband, M. N. & Zou, P., Dec 2023, In: Nature Communications. 14, 1, 8201.Research output: Contribution to journal › Article › peer-review
Open Access37 Scopus citations -
Directed mechanisms for apical dendrite development during neuronal polarization
Khan, T. A., Guo, A., Martin, J., Te Chien, C., Liu, T., Szczurkowska, J. & Shelly, M., Oct 2022, In: Developmental Biology. 490, p. 110-116 7 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Investigation of the photoluminescent properties, scintillation behaviour and toxicological profile of various magnesium tungstate nanoscale motifs
Hurley, N., Srinivas, S., Fang, J., Sun, M., Hong, S., Chien, C. T., Guo, A., Khan, T. A., Li, M., Cotlet, M., Moretti, F., Bourret, E., Radin, D., Tsirka, S. E., Shelly, M. & Wong, S. S., Dec 7 2022, In: Royal Society Open Science. 9, 12, 220994.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Semaphorin3A/PlexinA3 association with the Scribble scaffold for cGMP increase is required for apical dendrite development
Szczurkowska, J., Guo, A., Martin, J., Lee, S. I., Martinez, E., Chien, C. T., Khan, T. A., Singh, R., Dadson, D., Tran, T. S., Pautot, S. & Shelly, M., Mar 15 2022, In: Cell Reports. 38, 11, 110483.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations