Grants & Projects per year
Personal profile
Research interests
The Mao lab uses next-generation sequencing (NGS) and bioinformatics methods to study where DNA damage is formed in the genome and how it is repaired. Current research interests include:
(1) How do DNA repair proteins function in chromatin to remove DNA damage?
(2) How does the transcription machinery, including transcription factors, elongating RNA polymerase, and histone modification enzymes, impact different DNA repair pathways?
(3) How do cancer cells selectively modulate DNA repair pathways to tolerate chemotherapeutic agents?
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Environmental modifiers of UVR skin carcinogenesis: deciphering the effects of mixed exposures
Liu, K. J. (PI), Davuluri, R. (CoPI) & Mao, P. (CoPI)
National Inst of Environmental Health Sciences
09/3/26 → 08/31/27
Project: Research
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Repair of Temozolomide-Induced DNA Damage in Transcribed Genes
Mao, P. (PI) & Duan, M. (CoPI)
07/1/26 → 06/30/27
Project: Research
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Mechanism of Transcription-coupled DNA Repair and its Impact on Cancer Mutations
Mao, P. (PI) & Duan, M. (CoPI)
12/19/24 → 08/31/27
Project: Research
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The Mutational Mechanisms Shaping Melanocytes in Human Skin
Mao, P. (PI) & Duan, M. (CoPI)
National Inst of Arthritis Musculoskeletal & Skin
12/1/24 → 11/30/26
Project: Research
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Regulation of DNA Excision Repair in Chromatin
Mao, P. (PI) & Duan, M. (CoPI)
National Inst of Environmental Health Sciences
08/26/24 → 03/31/27
Project: Research
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Cisplatin in the era of PARP inhibitors and immunotherapy
Duan, M., Leng, S. & Mao, P., Jun 2024, In: Pharmacology and Therapeutics. 258, 108642.Research output: Contribution to journal › Review article › peer-review
Open Access44 Scopus citations -
High UV damage and low repair, but not cytosine deamination, stimulate mutation hotspots at ETS binding sites in melanoma
Duan, M., Song, S., Wasserman, H., Lee, P. H., Liu, K. J., Gordân, R., He, Y. & Mao, P., 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 4, e2310854121.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
The role of Transcription Factor IIH complex in nucleotide excision repair
Hoag, A., Duan, M. & Mao, P., Apr 2024, In: Environmental and Molecular Mutagenesis. 65, S1, p. 72-81 10 p.Research output: Contribution to journal › Review article › peer-review
Open Access17 Scopus citations -
Genome-wide maps of rare and atypical UV photoproducts reveal distinct patterns of damage formation and mutagenesis in yeast chromatin
Bohm, K. A., Morledge-Hampton, B., Stevison, S., Mao, P., Roberts, S. A. & Wyrick, J. J., Mar 7 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 10, e2216907120.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Comprehensive Analysis of Co-Mutations Identifies Cooperating Mechanisms of Tumorigenesis
Jiang, L., Yu, H., Ness, S., Mao, P., Guo, F., Tang, J. & Guo, Y., Jan 1 2022, In: Cancers. 14, 2, 415.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations