Grants & Projects per year
Personal profile
Research interests
My research is committed to studying the complexity inherent in biological systems for the purpose of improving human health. My lab focus is on Amyotrophic Lateral Sclerosis and neurodegenerative diseases. I feel that model organisms are vital tools with which we can answer fundamental questions about biology and medicine, based in molecular genetics, cellular and organismal biology, and developmental/degenerative biology. My research broadly encompasses three areas with related research questions, as follows:
- Nuclear Transport Defects in a Novel Form of Neurodegeneration
- Impact of Genetics and Environmental Toxicants on ALS
- The Role of Retrotransposons in Neurodegeneration
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Cell Cycle Dysregulation in Aging and Neurodegeneration
Sher, R. (PI)
01/1/25 → 06/30/28
Project: Research
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Retrotransposon Reactivation in ALS and AD/ADRD
Sher, R. (PI) & Dubnau, J. T. (CoPI)
11/1/24 → 03/31/27
Project: Research
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Center for Healthy Aging Pilot Program
Igarashi, P. (PI), DeLorenzo, C. (CoPI), Fields, S. (CoPI), Acosta, M. (CoI), Colognato, H. (CoI), Enikolopov, G. (CoI), Heslin, S. M. (CoI), Hu, C.-K. (CoI), Kaczocha, M. (CoI), Kim, H. (CoI), Kim, M. J. (CoI), Kumar, P. (CoI), Mackow, E. (CoI), Mathew, J. (CoI), Nadkarni, N. (CoI), Parker, M. (CoI), Rajupet, S. (CoI), Reich Marshall, N. C. (CoI), Riessland, M. (CoI), Rozensky, R. E. (CoI), Sher, R. (CoI), Sheridan, B. (CoI), Singer, A. (CoI), Sunar, U. (CoI), Tsirka, S. E. (CoI), Vorkas, C. K. (CoI), Wang, J. (CoI), Xiong, Q. (CoI) & Ye, F. (CoI)
08/1/23 → 12/31/27
Project: Research
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Thomas Hartman Center for Parkinson's Research
Fontanini, A. (PI), Bowen, M. E. (CoI), Collins III, W. (CoI), Colognato, H. (CoI), Hu, C.-K. (CoI), Kritzer, M. (CoI), Lamberg, E. M. (CoI), Leung, H. C. (CoI), Maffei, A. (CoI), Maurer, C. (CoI), Muratori, L. M. (CoI), Neiman, A. (CoI), Plotkin, J. (CoI), Puopolo, M. (CoI), Riessland, M. (CoI), Schwartz, G. (CoI), Shelly, M. (CoI), Sher, R. (CoI), Shrestha, P. (CoI), Sirotkin, H. I. (CoI), Solomon, I. C. (CoI), Thomsen IV, G. H. (CoI), Wollmuth, L. (CoI), Wu, S. (CoI), Xiong, Q. (CoI), Role, L. (PI), Christodoulou, C. (CoI), Evinger, L. (CoI), Halegoua, S. (CoI), Huang, C. (CoI), Levine, J. (CoI), Lutterbie, J. (CoI), Manganas, L. (CoI), Matthews, G. (CoI), Park, I. M. (CoI) & Talmage, D. (CoI)
04/15/13 → 08/31/27
Project: Research
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LINE-1 retrotransposition in a mouse TDP-43 model of neurodegeneration marks motor cortex neurons for cell-intrinsic and cell non-autonomous programmed cell death
Korada, S., Tam, O. H., Greco, H. C., Hammell, M. G., Dubnau, J. & Sher, R. B., Dec 29 2025, In: PLoS Genetics. 21, 12, e1012007.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Nuclear Import Defects Drive Cell Cycle Dysregulation in Neurodegeneration
Plessis-Belair, J., Russo, T., Riessland, M. & Sher, R. B., Aug 2025, In: Aging Cell. 24, 8, e70091.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Systematic profiling reveals distinct senescence signatures and regulators across human brain cell types
Russo, T., Plessis-Belair, J., Sher, R. & Riessland, M., Dec 2025, In: Nature Communications. 16, 1, 11059.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
NEMF mutations in mice illustrate how Importin-β specific nuclear transport defects recapitulate neurodegenerative disease hallmarks
Plessis-Belair, J., Ravano, K., Han, E., Janniello, A., Molina, C. & Sher, R. B., Sep 23 2024, In: PLoS Genetics. 20, 9, e1011411.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Ribosomal quality control factors inhibit repeat-associated non-AUG translation from GC-rich repeats
Tseng, Y. J., Krans, A., Malik, I., Deng, X., Yildirim, E., Ovunc, S., Tank, E. M. H., Jansen-West, K., Kaufhold, R., Gomez, N. B., Sher, R., Petrucelli, L., Barmada, S. J. & Todd, P. K., Jun 10 2024, In: Nucleic Acids Research. 52, 10, p. 5928-5949 22 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations