A case of mother and child with CANDLE syndrome: Diagnosis and subsequent treatment with baricitinib

William Guo; Daniel Lozeau; Marcia Tonnesen; Susan Schuval; Adriana de Jesus; Devin Miller; Sara Alehashemi; Leonard Kristal

doi:10.1111/pde.15667

A case of mother and child with CANDLE syndrome: Diagnosis and subsequent treatment with baricitinib

William Guo
, Daniel Lozeau
, Marcia Tonnesen
, Susan Schuval
, Adriana de Jesus
, Devin Miller
, Sara Alehashemi
, Leonard Kristal

Dermatology

Stony Brook University
National Institutes of Health

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) or proteasome-associated autoinflammatory syndrome is a rare autoinflammatory disorder that typically presents in infancy with characteristic symptoms, including recurrent fever, panniculitis, and progressive lipodystrophy, among other findings. We present a case of mother and child with CANDLE syndrome. The child was eventually started on baricitinib with normalization of rash and systemic findings.

Original language	English
Pages (from-to)	1162-1165
Number of pages	4
Journal	Pediatric Dermatology
Volume	41
Issue number	6
DOIs	https://doi.org/10.1111/pde.15667
State	Published - Nov 1 2024

Keywords

CANDLE syndrome
PRAAS
baricitinib

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10.1111/pde.15667

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title = "A case of mother and child with CANDLE syndrome: Diagnosis and subsequent treatment with baricitinib",

abstract = "Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) or proteasome-associated autoinflammatory syndrome is a rare autoinflammatory disorder that typically presents in infancy with characteristic symptoms, including recurrent fever, panniculitis, and progressive lipodystrophy, among other findings. We present a case of mother and child with CANDLE syndrome. The child was eventually started on baricitinib with normalization of rash and systemic findings.",

keywords = "CANDLE syndrome, PRAAS, baricitinib",

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T2 - Diagnosis and subsequent treatment with baricitinib

AU - Guo, William

AU - Lozeau, Daniel

AU - Tonnesen, Marcia

AU - Schuval, Susan

AU - de Jesus, Adriana

AU - Miller, Devin

AU - Alehashemi, Sara

AU - Kristal, Leonard

PY - 2024/11/1

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N2 - Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) or proteasome-associated autoinflammatory syndrome is a rare autoinflammatory disorder that typically presents in infancy with characteristic symptoms, including recurrent fever, panniculitis, and progressive lipodystrophy, among other findings. We present a case of mother and child with CANDLE syndrome. The child was eventually started on baricitinib with normalization of rash and systemic findings.

AB - Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) or proteasome-associated autoinflammatory syndrome is a rare autoinflammatory disorder that typically presents in infancy with characteristic symptoms, including recurrent fever, panniculitis, and progressive lipodystrophy, among other findings. We present a case of mother and child with CANDLE syndrome. The child was eventually started on baricitinib with normalization of rash and systemic findings.

KW - CANDLE syndrome

KW - PRAAS

KW - baricitinib

UR - https://www.scopus.com/pages/publications/85196157770

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DO - 10.1111/pde.15667

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JO - Pediatric Dermatology

JF - Pediatric Dermatology

IS - 6

ER -

A case of mother and child with CANDLE syndrome: Diagnosis and subsequent treatment with baricitinib

Abstract

Keywords

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