A highly efficient route to taxotere by the β-Lactam Synthon Method

Iwao Ojima; Chung Ming Sun; Martine Zucco; Young Hoon Park; Olivier Duclos; Scott Kuduk

doi:10.1016/S0040-4039(00)60514-2

A highly efficient route to taxotere by the β-Lactam Synthon Method

Iwao Ojima
, Chung Ming Sun
, Martine Zucco
, Young Hoon Park
, Olivier Duclos
, Scott Kuduk

Chemistry

Stony Brook University

Research output: Contribution to journal › Article › peer-review

140 Scopus citations

Abstract

Taxotère, a highly promising anticancer drug, is synthesized through an efficient coupling of 7,10-diTroc-10-deacetylbaccatin III with enantiomerically pure (3R,4S)-1-^tBOC-3-EEO- 4-phenylazetidin-2-one which is obtained via chiral ester enolate - imine cyclocondensation.

Original language	English
Pages (from-to)	4149-4152
Number of pages	4
Journal	Tetrahedron Letters
Volume	34
Issue number	26
DOIs	https://doi.org/10.1016/S0040-4039(00)60514-2
State	Published - Jun 25 1993

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10.1016/S0040-4039(00)60514-2

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title = "A highly efficient route to taxotere by the β-Lactam Synthon Method",

abstract = "Taxot{\`e}re, a highly promising anticancer drug, is synthesized through an efficient coupling of 7,10-diTroc-10-deacetylbaccatin III with enantiomerically pure (3R,4S)-1-tBOC-3-EEO- 4-phenylazetidin-2-one which is obtained via chiral ester enolate - imine cyclocondensation.",

author = "Iwao Ojima and Sun, \{Chung Ming\} and Martine Zucco and Park, \{Young Hoon\} and Olivier Duclos and Scott Kuduk",

year = "1993",

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T1 - A highly efficient route to taxotere by the β-Lactam Synthon Method

AU - Ojima, Iwao

AU - Sun, Chung Ming

AU - Zucco, Martine

AU - Park, Young Hoon

AU - Duclos, Olivier

AU - Kuduk, Scott

PY - 1993/6/25

Y1 - 1993/6/25

N2 - Taxotère, a highly promising anticancer drug, is synthesized through an efficient coupling of 7,10-diTroc-10-deacetylbaccatin III with enantiomerically pure (3R,4S)-1-tBOC-3-EEO- 4-phenylazetidin-2-one which is obtained via chiral ester enolate - imine cyclocondensation.

AB - Taxotère, a highly promising anticancer drug, is synthesized through an efficient coupling of 7,10-diTroc-10-deacetylbaccatin III with enantiomerically pure (3R,4S)-1-tBOC-3-EEO- 4-phenylazetidin-2-one which is obtained via chiral ester enolate - imine cyclocondensation.

UR - https://www.scopus.com/pages/publications/0027173282

U2 - 10.1016/S0040-4039(00)60514-2

DO - 10.1016/S0040-4039(00)60514-2

M3 - Article

AN - SCOPUS:0027173282

SN - 0040-4039

VL - 34

SP - 4149

EP - 4152

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 26

ER -

A highly efficient route to taxotere by the β-Lactam Synthon Method

Abstract

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