TY - GEN
T1 - A LSO beta microprobe for measuring input functions for quantitative small animal PET
AU - Maramraju, S.
AU - Stoll, S.
AU - Woody, C.
AU - Schlyer, D.
AU - Schiffer, W.
AU - Lee, D.
AU - Dewey, S.
AU - Vaska, P.
PY - 2006
Y1 - 2006
N2 - A miniature scintillation β microprobe has been developed to measure the input function in live rodents for use in longitudinal, quantitative PET studies. The probe consists of a small lutetium oxyorthosilicate (LSO) crystal measuring typically 0.3-0.6 mm diameter x 0.5-2 mm in length that is used to directly detect positrons in the blood or tissue. The probe has a sensitivity of 10-40 Hz/μCi/cc and is primarily sensitive to short range positrons emitted by labeled radiotracers in the blood. The sensitivity to gamma-ray background can be minimized using a variable threshold in the readout to discriminate between positrons and gammas. The probe was implanted in one of the tail veins of a Sprague-Dawley rat and the input function was measured for the injection of 0.8 mCi of FDG in the other tail vein. The probe exhibits a fast time response that is able to quickly and accurately measure the concentration of 18F circulating in the bloodstream. Additional tests were also carried out to study the probe's sensitivity to gamma ray background.
AB - A miniature scintillation β microprobe has been developed to measure the input function in live rodents for use in longitudinal, quantitative PET studies. The probe consists of a small lutetium oxyorthosilicate (LSO) crystal measuring typically 0.3-0.6 mm diameter x 0.5-2 mm in length that is used to directly detect positrons in the blood or tissue. The probe has a sensitivity of 10-40 Hz/μCi/cc and is primarily sensitive to short range positrons emitted by labeled radiotracers in the blood. The sensitivity to gamma-ray background can be minimized using a variable threshold in the readout to discriminate between positrons and gammas. The probe was implanted in one of the tail veins of a Sprague-Dawley rat and the input function was measured for the injection of 0.8 mCi of FDG in the other tail vein. The probe exhibits a fast time response that is able to quickly and accurately measure the concentration of 18F circulating in the bloodstream. Additional tests were also carried out to study the probe's sensitivity to gamma ray background.
UR - https://www.scopus.com/pages/publications/38549179322
U2 - 10.1109/NSSMIC.2006.356440
DO - 10.1109/NSSMIC.2006.356440
M3 - Conference contribution
AN - SCOPUS:38549179322
SN - 1424405610
SN - 9781424405619
T3 - IEEE Nuclear Science Symposium Conference Record
SP - 2713
EP - 2716
BT - 2006 IEEE Nuclear Science Symposium - Conference Record
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD
Y2 - 29 October 2006 through 4 November 2006
ER -