A MAPK Scaffold Lends a Helping Hand

Markus A. Seeliger; John Kuriyan

doi:10.1016/j.cell.2009.03.002

A MAPK Scaffold Lends a Helping Hand

Markus A. Seeliger
, John Kuriyan

Pharmacological Sciences

Howard Hughes Medical Institute
University of California at Berkeley
Lawrence Berkeley National Laboratory

Research output: Contribution to journal › Short survey › peer-review

6 Scopus citations

Abstract

The scaffold proteins of signaling pathways are thought to act as passive tethering devices bringing together catalytic components of signaling cascades. Good et al. (2009) now reveal that in the budding yeast the scaffold protein Ste5 acts as an allosteric activator of the mitogen-activated protein kinase Fus3, rendering it competent to be a kinase substrate for signal transmission.

Original language	English
Pages (from-to)	994-996
Number of pages	3
Journal	Cell
Volume	136
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2009.03.002
State	Published - Mar 20 2009

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10.1016/j.cell.2009.03.002

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title = "A MAPK Scaffold Lends a Helping Hand",

abstract = "The scaffold proteins of signaling pathways are thought to act as passive tethering devices bringing together catalytic components of signaling cascades. Good et al. (2009) now reveal that in the budding yeast the scaffold protein Ste5 acts as an allosteric activator of the mitogen-activated protein kinase Fus3, rendering it competent to be a kinase substrate for signal transmission.",

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T1 - A MAPK Scaffold Lends a Helping Hand

AU - Seeliger, Markus A.

AU - Kuriyan, John

PY - 2009/3/20

Y1 - 2009/3/20

N2 - The scaffold proteins of signaling pathways are thought to act as passive tethering devices bringing together catalytic components of signaling cascades. Good et al. (2009) now reveal that in the budding yeast the scaffold protein Ste5 acts as an allosteric activator of the mitogen-activated protein kinase Fus3, rendering it competent to be a kinase substrate for signal transmission.

AB - The scaffold proteins of signaling pathways are thought to act as passive tethering devices bringing together catalytic components of signaling cascades. Good et al. (2009) now reveal that in the budding yeast the scaffold protein Ste5 acts as an allosteric activator of the mitogen-activated protein kinase Fus3, rendering it competent to be a kinase substrate for signal transmission.

UR - https://www.scopus.com/pages/publications/62149128232

U2 - 10.1016/j.cell.2009.03.002

DO - 10.1016/j.cell.2009.03.002

M3 - Short survey

C2 - 19303841

AN - SCOPUS:62149128232

SN - 0092-8674

VL - 136

SP - 994

EP - 996

JO - Cell

JF - Cell

IS - 6

ER -

A MAPK Scaffold Lends a Helping Hand

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