TY - GEN
T1 - A mathematical model of pHi regulation in central CO 2- Chemoreception
AU - Cordovez, Juan M.
AU - Clausen, Chris
AU - Moore, Leon C.
AU - Solomon, Irene C.
PY - 2007
Y1 - 2007
N2 - In CO2 chemosensitive neurons, an increase in CO2 (hypercapnia) leads to a maintained reduction in intracellular pH (pH i) while in non-chemosensitive neurons pHi recovery is observed. The precise mechanisms for the differential regulation of pH i recovery between these cell populations remain to be identified; however, studies have begun to explore the role of Na+/H+ exchange (NHE). Here we present the results of a mathematical model that explores pHi regulation in central CO2 chemoreception, and in particular the role of the isoform NHE-5 (present in brainstem neurons). We found that NHE-5 kinetics leads to pHi recovery in response to simulated hypercapnia as we already reported for the isoforms NHE-1 and NHE-3. Further, we wanted to test whether our model can reproduce common experimental protocols like NH4+ pre-pulse experiments designed to alter pHi.
AB - In CO2 chemosensitive neurons, an increase in CO2 (hypercapnia) leads to a maintained reduction in intracellular pH (pH i) while in non-chemosensitive neurons pHi recovery is observed. The precise mechanisms for the differential regulation of pH i recovery between these cell populations remain to be identified; however, studies have begun to explore the role of Na+/H+ exchange (NHE). Here we present the results of a mathematical model that explores pHi regulation in central CO2 chemoreception, and in particular the role of the isoform NHE-5 (present in brainstem neurons). We found that NHE-5 kinetics leads to pHi recovery in response to simulated hypercapnia as we already reported for the isoforms NHE-1 and NHE-3. Further, we wanted to test whether our model can reproduce common experimental protocols like NH4+ pre-pulse experiments designed to alter pHi.
UR - https://www.scopus.com/pages/publications/48749117400
U2 - 10.1109/NEBC.2007.4413397
DO - 10.1109/NEBC.2007.4413397
M3 - Conference contribution
AN - SCOPUS:48749117400
SN - 1424410339
SN - 9781424410330
T3 - Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
SP - 300
EP - 301
BT - 33rd Annual Northeast Bioengineering Conference - Engineering Innovations in Life Sciences and Healthcare, NEBC
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 33rd Annual Northeast Bioengineering Conference, NEBC
Y2 - 10 March 2007 through 11 March 2007
ER -