A mathematical model of pHi regulation in central CO2 - Chemoreception

Juan M. Cordovez; Chris Clausen; Leon C. Moore; Irene C. Solomon

doi:10.1007/978-0-387-73693-8_53

A mathematical model of pH_i regulation in central CO₂ - Chemoreception

Juan M. Cordovez
, Chris Clausen
, Leon C. Moore
, Irene C. Solomon

Physiology and Biophysics

Stony Brook University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

In CO₂ chemosensitive neurons, an increase in CO₂ (hypercapnia) leads to a maintained reduction in intracellular pH (pH _i) while in non-chemosensitive neurons pH_i recovery is observed. The precise mechanisms for the differential regulation of pH _i recovery between these cell populations remain to be identified; however, studies have begun to explore the role of Na⁺/H⁺ exchange (NHE). Here, we compare the results of two different formulations of a mathematical model to begin to explore pHⁱ regulation in central CO₂ chemoreception.

Original language	English
Title of host publication	Integration in Respiratory Control
Subtitle of host publication	From Genes to Systems
Pages	306-311
Number of pages	6
DOIs	https://doi.org/10.1007/978-0-387-73693-8_53
State	Published - 2008

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	605
ISSN (Print)	0065-2598

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10.1007/978-0-387-73693-8_53

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title = "A mathematical model of pHi regulation in central CO2 - Chemoreception",

abstract = "In CO2 chemosensitive neurons, an increase in CO2 (hypercapnia) leads to a maintained reduction in intracellular pH (pH i) while in non-chemosensitive neurons pHi recovery is observed. The precise mechanisms for the differential regulation of pH i recovery between these cell populations remain to be identified; however, studies have begun to explore the role of Na+/H+ exchange (NHE). Here, we compare the results of two different formulations of a mathematical model to begin to explore pHi regulation in central CO2 chemoreception.",

author = "Cordovez, \{Juan M.\} and Chris Clausen and Moore, \{Leon C.\} and Solomon, \{Irene C.\}",

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A mathematical model of pH_i regulation in central CO₂ - Chemoreception. / Cordovez, Juan M.; Clausen, Chris; Moore, Leon C. et al.
Integration in Respiratory Control: From Genes to Systems. 2008. p. 306-311 (Advances in Experimental Medicine and Biology; Vol. 605).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

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AU - Cordovez, Juan M.

AU - Clausen, Chris

AU - Moore, Leon C.

AU - Solomon, Irene C.

PY - 2008

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N2 - In CO2 chemosensitive neurons, an increase in CO2 (hypercapnia) leads to a maintained reduction in intracellular pH (pH i) while in non-chemosensitive neurons pHi recovery is observed. The precise mechanisms for the differential regulation of pH i recovery between these cell populations remain to be identified; however, studies have begun to explore the role of Na+/H+ exchange (NHE). Here, we compare the results of two different formulations of a mathematical model to begin to explore pHi regulation in central CO2 chemoreception.

AB - In CO2 chemosensitive neurons, an increase in CO2 (hypercapnia) leads to a maintained reduction in intracellular pH (pH i) while in non-chemosensitive neurons pHi recovery is observed. The precise mechanisms for the differential regulation of pH i recovery between these cell populations remain to be identified; however, studies have begun to explore the role of Na+/H+ exchange (NHE). Here, we compare the results of two different formulations of a mathematical model to begin to explore pHi regulation in central CO2 chemoreception.

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DO - 10.1007/978-0-387-73693-8_53

M3 - Conference contribution

C2 - 18085290

AN - SCOPUS:38449104028

SN - 9780387736921

T3 - Advances in Experimental Medicine and Biology

SP - 306

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BT - Integration in Respiratory Control

ER -

A mathematical model of pH_i regulation in central CO₂ - Chemoreception

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