A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus

W. Cozen; M. N. Timofeeva; D. Li; A. Diepstra; D. Hazelett; M. Delahaye-Sourdeix; C. K. Edlund; L. Franke; K. Rostgaard; D. J. Van Den Berg; V. K. Cortessis; K. E. Smedby; S. L. Glaser; H. J. Westra; L. L. Robison; T. M. Mack; H. Ghesquieres; A. E. Hwang; A. Nieters; S. De Sanjose; T. Lightfoot; N. Becker; M. Maynadie; L. Foretova; E. Roman; Y. Benavente; K. A. Rand; B. N. Nathwani; B. Glimelius; A. Staines; P. Boffetta; B. K. Link; L. Kiemeney; S. M. Ansell; S. Bhatia; L. C. Strong; P. Galan; L. Vatten; T. M. Habermann; E. J. Duell; A. Lake; R. N. Veenstra; L. Visser; Y. Liu; K. Y. Urayama; D. Montgomery; V. Gaborieau; L. M. Weiss; G. Byrnes; M. Lathrop; P. Cocco; T. Best; A. D. Skol; H. O. Adami; M. Melbye; J. R. Cerhan; A. Gallagher; G. M. Taylor; S. L. Slager; P. Brennan; G. A. Coetzee; D. V. Conti; K. Onel; R. F. Jarrett; H. Hjalgrim; A. Van Den Berg; J. D. McKay

doi:10.1038/ncomms4856

A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus

W. Cozen
, M. N. Timofeeva
, D. Li
, A. Diepstra
, D. Hazelett
, M. Delahaye-Sourdeix
, C. K. Edlund
, L. Franke
, K. Rostgaard
, D. J. Van Den Berg
, V. K. Cortessis
, K. E. Smedby
, S. L. Glaser
, H. J. Westra
, L. L. Robison
, T. M. Mack
, H. Ghesquieres
, A. E. Hwang
, A. Nieters
, S. De Sanjose

T. Lightfoot, N. Becker, M. Maynadie, L. Foretova, E. Roman, Y. Benavente, K. A. Rand, B. N. Nathwani, B. Glimelius, A. Staines, P. Boffetta, B. K. Link, L. Kiemeney, S. M. Ansell, S. Bhatia, L. C. Strong, P. Galan, L. Vatten, T. M. Habermann, E. J. Duell, A. Lake, R. N. Veenstra, L. Visser, Y. Liu, K. Y. Urayama, D. Montgomery, V. Gaborieau, L. M. Weiss, G. Byrnes, M. Lathrop, P. Cocco, T. Best, A. D. Skol, H. O. Adami, M. Melbye, J. R. Cerhan, A. Gallagher, G. M. Taylor, S. L. Slager, P. Brennan, G. A. Coetzee, D. V. Conti, K. Onel, R. F. Jarrett, H. Hjalgrim, A. Van Den Berg, J. D. McKay

University of Southern California
International Agency for Research on Cancer
University of Edinburgh
Cedars-Sinai Medical Center
University of Groningen
Statens Serum Institut
Karolinska Institutet
Cancer Prevention Institute of California
St. Jude Children Research Hospital
Universite Claude Bernard Lyon 1
University of Freiburg
Institute Catala Oncologia
University of York
German Cancer Research Center
Université de Bourgogne
Masaryk Memorial Cancer Institute
City of Hope National Med Center
Uppsala University
Dublin City University
University of Iowa
Radboud University Nijmegen
Mayo Clinic Rochester, MN
University of Texas MD Anderson Cancer Center
Institut national de la santé et de la recherche médicale
Norwegian University of Science and Technology
MRC-University of Glasgow Centre for Virus Research
Institute of Science Tokyo
Clarient Pathology Services
Genome Quebec
University of Cagliari
The University of Chicago
Harvard University
University of Manchester

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

Recent genome-wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. Here we perform a meta-analysis of three HL GWAS totaling 1,816 cases and 7,877 controls followed by replication in an independent set of 1,281 cases and 3,218 controls to find novel risk loci. We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio (OR)=0.81, 95% confidence interval (95% CI)=0.76-0.86, P combined =3.5 × 10 10), located in intron 2 of TCF3 (also known as E2A), a regulator of B-and T-cell lineage commitment known to be involved in HL pathogenesis. This meta-analysis also notes associations between previously published loci at 2p16, 5q31, 6p31, 8q24 and 10p14 and HL subtypes. We conclude that our data suggest a link between the 19p13.3 locus, including TCF3, and HL risk.

Original language	English
Article number	3856
Journal	Nature Communications
Volume	5
DOIs	https://doi.org/10.1038/ncomms4856
State	Published - Jun 12 2014

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Cozen, W., Timofeeva, M. N., Li, D., Diepstra, A., Hazelett, D., Delahaye-Sourdeix, M., Edlund, C. K., Franke, L., Rostgaard, K., Van Den Berg, D. J., Cortessis, V. K., Smedby, K. E., Glaser, S. L., Westra, H. J., Robison, L. L., Mack, T. M., Ghesquieres, H., Hwang, A. E., Nieters, A., ... McKay, J. D. (2014). A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus. Nature Communications, 5, Article 3856. https://doi.org/10.1038/ncomms4856

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title = "A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus",

abstract = "Recent genome-wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. Here we perform a meta-analysis of three HL GWAS totaling 1,816 cases and 7,877 controls followed by replication in an independent set of 1,281 cases and 3,218 controls to find novel risk loci. We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio (OR)=0.81, 95\% confidence interval (95\% CI)=0.76-0.86, P combined =3.5 × 10 10), located in intron 2 of TCF3 (also known as E2A), a regulator of B-and T-cell lineage commitment known to be involved in HL pathogenesis. This meta-analysis also notes associations between previously published loci at 2p16, 5q31, 6p31, 8q24 and 10p14 and HL subtypes. We conclude that our data suggest a link between the 19p13.3 locus, including TCF3, and HL risk.",

author = "W. Cozen and Timofeeva, \{M. N.\} and D. Li and A. Diepstra and D. Hazelett and M. Delahaye-Sourdeix and Edlund, \{C. K.\} and L. Franke and K. Rostgaard and \{Van Den Berg\}, \{D. J.\} and Cortessis, \{V. K.\} and Smedby, \{K. E.\} and Glaser, \{S. L.\} and Westra, \{H. J.\} and Robison, \{L. L.\} and Mack, \{T. M.\} and H. Ghesquieres and Hwang, \{A. E.\} and A. Nieters and \{De Sanjose\}, S. and T. Lightfoot and N. Becker and M. Maynadie and L. Foretova and E. Roman and Y. Benavente and Rand, \{K. A.\} and Nathwani, \{B. N.\} and B. Glimelius and A. Staines and P. Boffetta and Link, \{B. K.\} and L. Kiemeney and Ansell, \{S. M.\} and S. Bhatia and Strong, \{L. C.\} and P. Galan and L. Vatten and Habermann, \{T. M.\} and Duell, \{E. J.\} and A. Lake and Veenstra, \{R. N.\} and L. Visser and Y. Liu and Urayama, \{K. Y.\} and D. Montgomery and V. Gaborieau and Weiss, \{L. M.\} and G. Byrnes and M. Lathrop and P. Cocco and T. Best and Skol, \{A. D.\} and Adami, \{H. O.\} and M. Melbye and Cerhan, \{J. R.\} and A. Gallagher and Taylor, \{G. M.\} and Slager, \{S. L.\} and P. Brennan and Coetzee, \{G. A.\} and Conti, \{D. V.\} and K. Onel and Jarrett, \{R. F.\} and H. Hjalgrim and \{Van Den Berg\}, A. and McKay, \{J. D.\}",

year = "2014",

month = jun,

day = "12",

doi = "10.1038/ncomms4856",

language = "English",

volume = "5",

journal = "Nature Communications",

issn = "2041-1723",

}

Cozen, W, Timofeeva, MN, Li, D, Diepstra, A, Hazelett, D, Delahaye-Sourdeix, M, Edlund, CK, Franke, L, Rostgaard, K, Van Den Berg, DJ, Cortessis, VK, Smedby, KE, Glaser, SL, Westra, HJ, Robison, LL, Mack, TM, Ghesquieres, H, Hwang, AE, Nieters, A, De Sanjose, S, Lightfoot, T, Becker, N, Maynadie, M, Foretova, L, Roman, E, Benavente, Y, Rand, KA, Nathwani, BN, Glimelius, B, Staines, A, Boffetta, P, Link, BK, Kiemeney, L, Ansell, SM, Bhatia, S, Strong, LC, Galan, P, Vatten, L, Habermann, TM, Duell, EJ, Lake, A, Veenstra, RN, Visser, L, Liu, Y, Urayama, KY, Montgomery, D, Gaborieau, V, Weiss, LM, Byrnes, G, Lathrop, M, Cocco, P, Best, T, Skol, AD, Adami, HO, Melbye, M, Cerhan, JR, Gallagher, A, Taylor, GM, Slager, SL, Brennan, P, Coetzee, GA, Conti, DV, Onel, K, Jarrett, RF, Hjalgrim, H, Van Den Berg, A & McKay, JD 2014, 'A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus', Nature Communications, vol. 5, 3856. https://doi.org/10.1038/ncomms4856

TY - JOUR

T1 - A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus

AU - Cozen, W.

AU - Timofeeva, M. N.

AU - Li, D.

AU - Diepstra, A.

AU - Hazelett, D.

AU - Delahaye-Sourdeix, M.

AU - Edlund, C. K.

AU - Franke, L.

AU - Rostgaard, K.

AU - Van Den Berg, D. J.

AU - Cortessis, V. K.

AU - Smedby, K. E.

AU - Glaser, S. L.

AU - Westra, H. J.

AU - Robison, L. L.

AU - Mack, T. M.

AU - Ghesquieres, H.

AU - Hwang, A. E.

AU - Nieters, A.

AU - De Sanjose, S.

AU - Lightfoot, T.

AU - Becker, N.

AU - Maynadie, M.

AU - Foretova, L.

AU - Roman, E.

AU - Benavente, Y.

AU - Rand, K. A.

AU - Nathwani, B. N.

AU - Glimelius, B.

AU - Staines, A.

AU - Boffetta, P.

AU - Link, B. K.

AU - Kiemeney, L.

AU - Ansell, S. M.

AU - Bhatia, S.

AU - Strong, L. C.

AU - Galan, P.

AU - Vatten, L.

AU - Habermann, T. M.

AU - Duell, E. J.

AU - Lake, A.

AU - Veenstra, R. N.

AU - Visser, L.

AU - Liu, Y.

AU - Urayama, K. Y.

AU - Montgomery, D.

AU - Gaborieau, V.

AU - Weiss, L. M.

AU - Byrnes, G.

AU - Lathrop, M.

AU - Cocco, P.

AU - Best, T.

AU - Skol, A. D.

AU - Adami, H. O.

AU - Melbye, M.

AU - Cerhan, J. R.

AU - Gallagher, A.

AU - Taylor, G. M.

AU - Slager, S. L.

AU - Brennan, P.

AU - Coetzee, G. A.

AU - Conti, D. V.

AU - Onel, K.

AU - Jarrett, R. F.

AU - Hjalgrim, H.

AU - Van Den Berg, A.

AU - McKay, J. D.

PY - 2014/6/12

Y1 - 2014/6/12

N2 - Recent genome-wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. Here we perform a meta-analysis of three HL GWAS totaling 1,816 cases and 7,877 controls followed by replication in an independent set of 1,281 cases and 3,218 controls to find novel risk loci. We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio (OR)=0.81, 95% confidence interval (95% CI)=0.76-0.86, P combined =3.5 × 10 10), located in intron 2 of TCF3 (also known as E2A), a regulator of B-and T-cell lineage commitment known to be involved in HL pathogenesis. This meta-analysis also notes associations between previously published loci at 2p16, 5q31, 6p31, 8q24 and 10p14 and HL subtypes. We conclude that our data suggest a link between the 19p13.3 locus, including TCF3, and HL risk.

AB - Recent genome-wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. Here we perform a meta-analysis of three HL GWAS totaling 1,816 cases and 7,877 controls followed by replication in an independent set of 1,281 cases and 3,218 controls to find novel risk loci. We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio (OR)=0.81, 95% confidence interval (95% CI)=0.76-0.86, P combined =3.5 × 10 10), located in intron 2 of TCF3 (also known as E2A), a regulator of B-and T-cell lineage commitment known to be involved in HL pathogenesis. This meta-analysis also notes associations between previously published loci at 2p16, 5q31, 6p31, 8q24 and 10p14 and HL subtypes. We conclude that our data suggest a link between the 19p13.3 locus, including TCF3, and HL risk.

UR - https://www.scopus.com/pages/publications/84902440665

U2 - 10.1038/ncomms4856

DO - 10.1038/ncomms4856

M3 - Article

C2 - 24920014

AN - SCOPUS:84902440665

SN - 2041-1723

VL - 5

JO - Nature Communications

JF - Nature Communications

M1 - 3856

ER -

A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus

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