A mouse model of Borrelia meningitis after intradermal injection

Juan C. Garcia-Monco; Nancy S. Miller; P. Bryon Backenson; Pedro Anda; Jorge L. Benach

doi:10.1086/593681

A mouse model of Borrelia meningitis after intradermal injection

Juan C. Garcia-Monco
, Nancy S. Miller
, P. Bryon Backenson
, Pedro Anda
, Jorge L. Benach

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34 Scopus citations

Abstract

Both young and adult C3H/HeN mice developed meningitis within 3 weeks of intradermal inoculation with a newly identified uncultivable Borrelia species, an agent of human relapsing fever. Meningoencephalitis with perivascular infiltrates and plexitis developed at ~25 days after inoculation. Infiltrates were composed of B and plasma cells and monocytes. This model recreated the meningitis associated with spirochetal infections through an intradermal route of infection.

Original language	English
Pages (from-to)	1243-1245
Number of pages	3
Journal	Journal of Infectious Diseases
Volume	175
Issue number	5
DOIs	https://doi.org/10.1086/593681
State	Published - 1997

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10.1086/593681

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title = "A mouse model of Borrelia meningitis after intradermal injection",

abstract = "Both young and adult C3H/HeN mice developed meningitis within 3 weeks of intradermal inoculation with a newly identified uncultivable Borrelia species, an agent of human relapsing fever. Meningoencephalitis with perivascular infiltrates and plexitis developed at \textasciitilde{}25 days after inoculation. Infiltrates were composed of B and plasma cells and monocytes. This model recreated the meningitis associated with spirochetal infections through an intradermal route of infection.",

author = "Garcia-Monco, \{Juan C.\} and Miller, \{Nancy S.\} and \{Bryon Backenson\}, P. and Pedro Anda and Benach, \{Jorge L.\}",

year = "1997",

doi = "10.1086/593681",

language = "English",

volume = "175",

pages = "1243--1245",

journal = "Journal of Infectious Diseases",

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T1 - A mouse model of Borrelia meningitis after intradermal injection

AU - Garcia-Monco, Juan C.

AU - Miller, Nancy S.

AU - Bryon Backenson, P.

AU - Anda, Pedro

AU - Benach, Jorge L.

PY - 1997

Y1 - 1997

N2 - Both young and adult C3H/HeN mice developed meningitis within 3 weeks of intradermal inoculation with a newly identified uncultivable Borrelia species, an agent of human relapsing fever. Meningoencephalitis with perivascular infiltrates and plexitis developed at ~25 days after inoculation. Infiltrates were composed of B and plasma cells and monocytes. This model recreated the meningitis associated with spirochetal infections through an intradermal route of infection.

AB - Both young and adult C3H/HeN mice developed meningitis within 3 weeks of intradermal inoculation with a newly identified uncultivable Borrelia species, an agent of human relapsing fever. Meningoencephalitis with perivascular infiltrates and plexitis developed at ~25 days after inoculation. Infiltrates were composed of B and plasma cells and monocytes. This model recreated the meningitis associated with spirochetal infections through an intradermal route of infection.

UR - https://www.scopus.com/pages/publications/0030944195

U2 - 10.1086/593681

DO - 10.1086/593681

M3 - Article

C2 - 9129096

AN - SCOPUS:0030944195

SN - 0022-1899

VL - 175

SP - 1243

EP - 1245

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 5

ER -

A mouse model of Borrelia meningitis after intradermal injection

Abstract

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