A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening

Ho Sang Moon; Eric M. Jacobson; Sonya M. Khersonsky; Michael R. Luzung; Daniel P. Walsh; Wennan Xiong; Jae Wook Lee; Puja B. Parikh; Jennifer C. Lam; Tae Wook Kang; Gustavo R. Rosania; Alexander F. Schier; Young Tae Chang

doi:10.1021/ja026720i

A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening

Ho Sang Moon
, Eric M. Jacobson
, Sonya M. Khersonsky
, Michael R. Luzung
, Daniel P. Walsh
, Wennan Xiong
, Jae Wook Lee
, Puja B. Parikh
, Jennifer C. Lam
, Tae Wook Kang
, Gustavo R. Rosania
, Alexander F. Schier
, Young Tae Chang

Department of Medicine - Division of Cardiology

New York University
University of Michigan, Ann Arbor

Research output: Contribution to journal › Article › peer-review

128 Scopus citations

Abstract

The first orthogonal combinatorial synthesis of a high-purity triazine library was demonstrated. Novel triazine-based microtubule inhibitors were discovered by an efficient zebrafish embryo screening and in vitro microtubule polymerization assay.

Original language	English
Pages (from-to)	11608-11609
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	124
Issue number	39
DOIs	https://doi.org/10.1021/ja026720i
State	Published - Oct 2 2002

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Moon, H. S., Jacobson, E. M., Khersonsky, S. M., Luzung, M. R., Walsh, D. P., Xiong, W., Lee, J. W., Parikh, P. B., Lam, J. C., Kang, T. W., Rosania, G. R., Schier, A. F., & Chang, Y. T. (2002). A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening. Journal of the American Chemical Society, 124(39), 11608-11609. https://doi.org/10.1021/ja026720i

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title = "A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening",

abstract = "The first orthogonal combinatorial synthesis of a high-purity triazine library was demonstrated. Novel triazine-based microtubule inhibitors were discovered by an efficient zebrafish embryo screening and in vitro microtubule polymerization assay.",

author = "Moon, \{Ho Sang\} and Jacobson, \{Eric M.\} and Khersonsky, \{Sonya M.\} and Luzung, \{Michael R.\} and Walsh, \{Daniel P.\} and Wennan Xiong and Lee, \{Jae Wook\} and Parikh, \{Puja B.\} and Lam, \{Jennifer C.\} and Kang, \{Tae Wook\} and Rosania, \{Gustavo R.\} and Schier, \{Alexander F.\} and Chang, \{Young Tae\}",

year = "2002",

month = oct,

day = "2",

doi = "10.1021/ja026720i",

language = "English",

volume = "124",

pages = "11608--11609",

journal = "Journal of the American Chemical Society",

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Moon, HS, Jacobson, EM, Khersonsky, SM, Luzung, MR, Walsh, DP, Xiong, W, Lee, JW, Parikh, PB, Lam, JC, Kang, TW, Rosania, GR, Schier, AF & Chang, YT 2002, 'A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening', Journal of the American Chemical Society, vol. 124, no. 39, pp. 11608-11609. https://doi.org/10.1021/ja026720i

TY - JOUR

T1 - A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening

AU - Moon, Ho Sang

AU - Jacobson, Eric M.

AU - Khersonsky, Sonya M.

AU - Luzung, Michael R.

AU - Walsh, Daniel P.

AU - Xiong, Wennan

AU - Lee, Jae Wook

AU - Parikh, Puja B.

AU - Lam, Jennifer C.

AU - Kang, Tae Wook

AU - Rosania, Gustavo R.

AU - Schier, Alexander F.

AU - Chang, Young Tae

PY - 2002/10/2

Y1 - 2002/10/2

N2 - The first orthogonal combinatorial synthesis of a high-purity triazine library was demonstrated. Novel triazine-based microtubule inhibitors were discovered by an efficient zebrafish embryo screening and in vitro microtubule polymerization assay.

AB - The first orthogonal combinatorial synthesis of a high-purity triazine library was demonstrated. Novel triazine-based microtubule inhibitors were discovered by an efficient zebrafish embryo screening and in vitro microtubule polymerization assay.

UR - https://www.scopus.com/pages/publications/0037009971

U2 - 10.1021/ja026720i

DO - 10.1021/ja026720i

M3 - Article

C2 - 12296721

AN - SCOPUS:0037009971

SN - 0002-7863

VL - 124

SP - 11608

EP - 11609

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 39

ER -

A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening

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