A probe specific empirical light transport model for improved quantification of optical parameters for accurate PDT dosimetry

Daniel J. Rohrbach; Andrew Kowalczewski; Borui Chen; Ulas Sunar

doi:10.1117/12.2005051

A probe specific empirical light transport model for improved quantification of optical parameters for accurate PDT dosimetry

Daniel J. Rohrbach
, Andrew Kowalczewski
, Borui Chen
, Ulas Sunar

Dept of Biomedical Engineering

Roswell Park Cancer Institute

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

Diffuse reflectance spectroscopy (DRS) is a common technique for assessing tissue optical parameters (absorption, scattering) non-invasively. However, choosing the correct model for light-tissue interaction is needed for accurate quantification. The diffusion approximation is only valid for certain ranges of tissue optical properties and specific probe geometries. For improved quantification with DRS over a wide range of optical properties and for a short source detector separation, a probe-specific light transport model can provide more accurate analysis of optical parameters. We developed and tested a probe-specific empirical model by using tissue simulating phantoms with promising results. We will apply it for the analysis of patients from a clinical trial for head and neck cancer.

Original language	English
Title of host publication	Optical Methods for Tumor Treatment and Detection
Subtitle of host publication	Mechanisms and Techniques in Photodynamic Therapy XXII
DOIs	https://doi.org/10.1117/12.2005051
State	Published - 2013
Event	Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII - San Francisco, CA, United States Duration: Feb 2 2013 → Feb 4 2013

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	8568
ISSN (Print)	1605-7422

Conference

Conference	Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII
Country/Territory	United States
City	San Francisco, CA
Period	02/2/13 → 02/4/13

Keywords

diffuse optical spectroscopy
empirical light transport
therapy monitoring

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10.1117/12.2005051

Cite this

Rohrbach, D. J., Kowalczewski, A., Chen, B., & Sunar, U. (2013). A probe specific empirical light transport model for improved quantification of optical parameters for accurate PDT dosimetry. In Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII Article 856815 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8568). https://doi.org/10.1117/12.2005051

Rohrbach, Daniel J. ; Kowalczewski, Andrew ; Chen, Borui et al. / A probe specific empirical light transport model for improved quantification of optical parameters for accurate PDT dosimetry. Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII. 2013. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

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title = "A probe specific empirical light transport model for improved quantification of optical parameters for accurate PDT dosimetry",

abstract = "Diffuse reflectance spectroscopy (DRS) is a common technique for assessing tissue optical parameters (absorption, scattering) non-invasively. However, choosing the correct model for light-tissue interaction is needed for accurate quantification. The diffusion approximation is only valid for certain ranges of tissue optical properties and specific probe geometries. For improved quantification with DRS over a wide range of optical properties and for a short source detector separation, a probe-specific light transport model can provide more accurate analysis of optical parameters. We developed and tested a probe-specific empirical model by using tissue simulating phantoms with promising results. We will apply it for the analysis of patients from a clinical trial for head and neck cancer.",

keywords = "diffuse optical spectroscopy, empirical light transport, therapy monitoring",

author = "Rohrbach, \{Daniel J.\} and Andrew Kowalczewski and Borui Chen and Ulas Sunar",

year = "2013",

doi = "10.1117/12.2005051",

language = "English",

isbn = "9780819493378",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

booktitle = "Optical Methods for Tumor Treatment and Detection",

note = "Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII ; Conference date: 02-02-2013 Through 04-02-2013",

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Rohrbach, DJ, Kowalczewski, A, Chen, B & Sunar, U 2013, A probe specific empirical light transport model for improved quantification of optical parameters for accurate PDT dosimetry. in Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII., 856815, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, San Francisco, CA, United States, 02/2/13. https://doi.org/10.1117/12.2005051

A probe specific empirical light transport model for improved quantification of optical parameters for accurate PDT dosimetry. / Rohrbach, Daniel J.; Kowalczewski, Andrew; Chen, Borui et al.
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII. 2013. 856815 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8568).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - A probe specific empirical light transport model for improved quantification of optical parameters for accurate PDT dosimetry

AU - Rohrbach, Daniel J.

AU - Kowalczewski, Andrew

AU - Chen, Borui

AU - Sunar, Ulas

PY - 2013

Y1 - 2013

N2 - Diffuse reflectance spectroscopy (DRS) is a common technique for assessing tissue optical parameters (absorption, scattering) non-invasively. However, choosing the correct model for light-tissue interaction is needed for accurate quantification. The diffusion approximation is only valid for certain ranges of tissue optical properties and specific probe geometries. For improved quantification with DRS over a wide range of optical properties and for a short source detector separation, a probe-specific light transport model can provide more accurate analysis of optical parameters. We developed and tested a probe-specific empirical model by using tissue simulating phantoms with promising results. We will apply it for the analysis of patients from a clinical trial for head and neck cancer.

AB - Diffuse reflectance spectroscopy (DRS) is a common technique for assessing tissue optical parameters (absorption, scattering) non-invasively. However, choosing the correct model for light-tissue interaction is needed for accurate quantification. The diffusion approximation is only valid for certain ranges of tissue optical properties and specific probe geometries. For improved quantification with DRS over a wide range of optical properties and for a short source detector separation, a probe-specific light transport model can provide more accurate analysis of optical parameters. We developed and tested a probe-specific empirical model by using tissue simulating phantoms with promising results. We will apply it for the analysis of patients from a clinical trial for head and neck cancer.

KW - diffuse optical spectroscopy

KW - empirical light transport

KW - therapy monitoring

UR - https://www.scopus.com/pages/publications/84878143491

U2 - 10.1117/12.2005051

DO - 10.1117/12.2005051

M3 - Conference contribution

AN - SCOPUS:84878143491

SN - 9780819493378

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Optical Methods for Tumor Treatment and Detection

T2 - Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII

Y2 - 2 February 2013 through 4 February 2013

ER -

Rohrbach DJ, Kowalczewski A, Chen B, Sunar U. A probe specific empirical light transport model for improved quantification of optical parameters for accurate PDT dosimetry. In Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII. 2013. 856815. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2005051

A probe specific empirical light transport model for improved quantification of optical parameters for accurate PDT dosimetry

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