A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers

Dan Chen; Therese Truong; Valerie Gaborieau; Graham Byrnes; Amelie Chabrier; Shu Chun Chuang; Andrew F. Olshan; Mark C. Weissler; Jingchun Luo; Marjorie Romkes; Shama Buch; Tomoko Nukui; Silvia Franceschi; Rolando Herrero; Renato Talamini; Karl T. Kelsey; Brock Christensen; Michael D. McClean; Martin Lacko; Johannes J. Manni; Wilbert H.M. Peters; Jan Lubiński; Joanna Trubicka; Marcin Lener; Joshua E. Muscat; Philip Lazarus; Qingyi Wei; Erich M. Sturgis; Zuo Feng Zhang; Shen Chih Chang; Renyi Wang; Stephen M. Schwartz; Chu Chen; Simone Benhamou; Pagona Lagiou; Ivana Holcátová; Lorenzo Richiardi; Kristina Kjaerheim; Antonio Agudo; Xavier Castellsagué; Tatiana V. Macfarlane; Luigi Barzan; Cristina Canova; Nalin S. Thakker; David I. Conway; Ariana Znaor; Claire M. Healy; Wolfgang Ahrens; David Zaridze; Neonila Szeszenia-Dabrowska; Jolanta Lissowska; Eleonora Fabianova; Alexandru Bucur; Vladimir Bencko; Lenka Foretova; Vladimir Janout; Maria Paula Curado; Sergio Koifman; Ana Menezes; Victor Wünsch-Filho; José Eluf-Neto; Leticia Fernandez; Stefania Boccia; Mia Hashibe; Richard B. Hayes; Paolo Boffetta; Paul Brennan; James D. McKay

doi:10.1158/1055-9965.EPI-10-1008

A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers

Dan Chen
, Therese Truong
, Valerie Gaborieau
, Graham Byrnes
, Amelie Chabrier
, Shu Chun Chuang
, Andrew F. Olshan
, Mark C. Weissler
, Jingchun Luo
, Marjorie Romkes
, Shama Buch
, Tomoko Nukui
, Silvia Franceschi
, Rolando Herrero
, Renato Talamini
, Karl T. Kelsey
, Brock Christensen
, Michael D. McClean
, Martin Lacko
, Johannes J. Manni

Wilbert H.M. Peters, Jan Lubiński, Joanna Trubicka, Marcin Lener, Joshua E. Muscat, Philip Lazarus, Qingyi Wei, Erich M. Sturgis, Zuo Feng Zhang, Shen Chih Chang, Renyi Wang, Stephen M. Schwartz, Chu Chen, Simone Benhamou, Pagona Lagiou, Ivana Holcátová, Lorenzo Richiardi, Kristina Kjaerheim, Antonio Agudo, Xavier Castellsagué, Tatiana V. Macfarlane, Luigi Barzan, Cristina Canova, Nalin S. Thakker, David I. Conway, Ariana Znaor, Claire M. Healy, Wolfgang Ahrens, David Zaridze, Neonila Szeszenia-Dabrowska, Jolanta Lissowska, Eleonora Fabianova, Alexandru Bucur, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Maria Paula Curado, Sergio Koifman, Ana Menezes, Victor Wünsch-Filho, José Eluf-Neto, Leticia Fernandez, Stefania Boccia, Mia Hashibe, Richard B. Hayes, Paolo Boffetta, Paul Brennan, James D. McKay

Family , Population and Preventative Medicine

International Agency for Research on Cancer
University of North Carolina at Chapel Hill
University of Pittsburgh
Instituto de Investigación Epidemiológica
IRCCS Centro di Riferimento Oncologico - Aviano PN
Brown University
Boston University
Maastricht University
Radboud University Nijmegen
Pomeranian Medical University in Szczecin
Pennsylvania State University
University of Texas MD Anderson Cancer Center
University of California at Los Angeles
Fred Hutchinson Cancer Research Center
Institut national de la santé et de la recherche médicale
University of Paris Sud
National and Kapodistrian University of Athens
Charles University
University of Turin
Cancer Registry of Norway Institute of Population-Based Cancer Research
Institute Catala Oncologia
Consortium for Biomed. Res. in Epidemiol. and Pub. Hlth.
University of Aberdeen
General Hospital of Pordenone
University of Padua
School of Public Health
University of Manchester
University of Glasgow
Croatian National Institute of Public Health
Trinity College Dublin
University of Bremen
Cancer Research Site
Nofer Institute of Occupational Medicine
Maria Sklodowska-Curie Institute of Oncology
Regional Authority of Public Health
National Institute of Public Health
Masaryk Memorial Cancer Institute
Palacký University Olomouc
Escola Nacional de Suade Publica
Universidade Federal de Pelotas
Universidade de São Paulo
National School of Public Health
Catholic University of the Sacred Heart
IRCCS San Raffaele Pisana - Roma
University of Utah
New York University

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Background: Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx, and esophagus) in women (OR = 1.24, P = 0.003) with little effect in men (OR = 1.04, P = 0.35). Methods: In a coordinated genotyping study within the International Head and Neck Cancer Epidemiology (INHANCE) consortium, we have sought to replicate these findings in an additional 4,604 cases and 6,239 controls from 10 independent UADT cancer case - control studies. Results: rs16969968 was again associated with UADT cancers in women (OR = 1.21, 95% CI = 1.08-1.36, P = 0.001) and a similar lack of observed effect in men [OR = 1.02, 95% CI = 0.95-1.09, P = 0.66; P-heterogeneity (P _het) = 0.01]. In a pooled analysis of the original and current studies, totaling 8,572 UADT cancer cases and 11,558 controls, the association was observed among females (OR = 1.22, 95% CI = 1.12-1.34, P = 7 × 10 ^-6) but not males (OR = 1.02, 95% CI = 0.97-1.08, P = 0.35; P _het = 6 × 10^-4). There was little evidence for a sex difference in the association between this variant and cigarettes smoked per day, with male and female rs16969968 variant carriers smoking approximately the same amount more in the 11,991 ever smokers in the pooled analysis of the 14 studies (P_het = 0.86). Conclusions: This study has confirmed a sex difference in the association between the 15q25 variant rs16969968 and UADT cancers. Impact: Further research is warranted to elucidate the mechanisms underlying these observations.

Original language	English
Pages (from-to)	658-664
Number of pages	7
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	20
Issue number	4
DOIs	https://doi.org/10.1158/1055-9965.EPI-10-1008
State	Published - Apr 2011

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10.1158/1055-9965.EPI-10-1008

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Chen, D., Truong, T., Gaborieau, V., Byrnes, G., Chabrier, A., Chuang, S. C., Olshan, A. F., Weissler, M. C., Luo, J., Romkes, M., Buch, S., Nukui, T., Franceschi, S., Herrero, R., Talamini, R., Kelsey, K. T., Christensen, B., McClean, M. D., Lacko, M., ... McKay, J. D. (2011). A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers. Cancer Epidemiology Biomarkers and Prevention, 20(4), 658-664. https://doi.org/10.1158/1055-9965.EPI-10-1008

@article{1ca4a6f604fa4b8486cd30dee0f5d7c7,

title = "A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers",

abstract = "Background: Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx, and esophagus) in women (OR = 1.24, P = 0.003) with little effect in men (OR = 1.04, P = 0.35). Methods: In a coordinated genotyping study within the International Head and Neck Cancer Epidemiology (INHANCE) consortium, we have sought to replicate these findings in an additional 4,604 cases and 6,239 controls from 10 independent UADT cancer case - control studies. Results: rs16969968 was again associated with UADT cancers in women (OR = 1.21, 95\% CI = 1.08-1.36, P = 0.001) and a similar lack of observed effect in men [OR = 1.02, 95\% CI = 0.95-1.09, P = 0.66; P-heterogeneity (P het) = 0.01]. In a pooled analysis of the original and current studies, totaling 8,572 UADT cancer cases and 11,558 controls, the association was observed among females (OR = 1.22, 95\% CI = 1.12-1.34, P = 7 × 10 -6) but not males (OR = 1.02, 95\% CI = 0.97-1.08, P = 0.35; P het = 6 × 10-4). There was little evidence for a sex difference in the association between this variant and cigarettes smoked per day, with male and female rs16969968 variant carriers smoking approximately the same amount more in the 11,991 ever smokers in the pooled analysis of the 14 studies (Phet = 0.86). Conclusions: This study has confirmed a sex difference in the association between the 15q25 variant rs16969968 and UADT cancers. Impact: Further research is warranted to elucidate the mechanisms underlying these observations.",

author = "Dan Chen and Therese Truong and Valerie Gaborieau and Graham Byrnes and Amelie Chabrier and Chuang, \{Shu Chun\} and Olshan, \{Andrew F.\} and Weissler, \{Mark C.\} and Jingchun Luo and Marjorie Romkes and Shama Buch and Tomoko Nukui and Silvia Franceschi and Rolando Herrero and Renato Talamini and Kelsey, \{Karl T.\} and Brock Christensen and McClean, \{Michael D.\} and Martin Lacko and Manni, \{Johannes J.\} and Peters, \{Wilbert H.M.\} and Jan Lubi{\'n}ski and Joanna Trubicka and Marcin Lener and Muscat, \{Joshua E.\} and Philip Lazarus and Qingyi Wei and Sturgis, \{Erich M.\} and Zhang, \{Zuo Feng\} and Chang, \{Shen Chih\} and Renyi Wang and Schwartz, \{Stephen M.\} and Chu Chen and Simone Benhamou and Pagona Lagiou and Ivana Holc{\'a}tov{\'a} and Lorenzo Richiardi and Kristina Kjaerheim and Antonio Agudo and Xavier Castellsagu{\'e} and Macfarlane, \{Tatiana V.\} and Luigi Barzan and Cristina Canova and Thakker, \{Nalin S.\} and Conway, \{David I.\} and Ariana Znaor and Healy, \{Claire M.\} and Wolfgang Ahrens and David Zaridze and Neonila Szeszenia-Dabrowska and Jolanta Lissowska and Eleonora Fabianova and Alexandru Bucur and Vladimir Bencko and Lenka Foretova and Vladimir Janout and Curado, \{Maria Paula\} and Sergio Koifman and Ana Menezes and Victor W{\"u}nsch-Filho and Jos{\'e} Eluf-Neto and Leticia Fernandez and Stefania Boccia and Mia Hashibe and Hayes, \{Richard B.\} and Paolo Boffetta and Paul Brennan and McKay, \{James D.\}",

year = "2011",

month = apr,

doi = "10.1158/1055-9965.EPI-10-1008",

language = "English",

volume = "20",

pages = "658--664",

journal = "Cancer Epidemiology Biomarkers and Prevention",

issn = "1055-9965",

number = "4",

}

Chen, D, Truong, T, Gaborieau, V, Byrnes, G, Chabrier, A, Chuang, SC, Olshan, AF, Weissler, MC, Luo, J, Romkes, M, Buch, S, Nukui, T, Franceschi, S, Herrero, R, Talamini, R, Kelsey, KT, Christensen, B, McClean, MD, Lacko, M, Manni, JJ, Peters, WHM, Lubiński, J, Trubicka, J, Lener, M, Muscat, JE, Lazarus, P, Wei, Q, Sturgis, EM, Zhang, ZF, Chang, SC, Wang, R, Schwartz, SM, Chen, C, Benhamou, S, Lagiou, P, Holcátová, I, Richiardi, L, Kjaerheim, K, Agudo, A, Castellsagué, X, Macfarlane, TV, Barzan, L, Canova, C, Thakker, NS, Conway, DI, Znaor, A, Healy, CM, Ahrens, W, Zaridze, D, Szeszenia-Dabrowska, N, Lissowska, J, Fabianova, E, Bucur, A, Bencko, V, Foretova, L, Janout, V, Curado, MP, Koifman, S, Menezes, A, Wünsch-Filho, V, Eluf-Neto, J, Fernandez, L, Boccia, S, Hashibe, M, Hayes, RB, Boffetta, P, Brennan, P & McKay, JD 2011, 'A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers', Cancer Epidemiology Biomarkers and Prevention, vol. 20, no. 4, pp. 658-664. https://doi.org/10.1158/1055-9965.EPI-10-1008

TY - JOUR

T1 - A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers

AU - Chen, Dan

AU - Truong, Therese

AU - Gaborieau, Valerie

AU - Byrnes, Graham

AU - Chabrier, Amelie

AU - Chuang, Shu Chun

AU - Olshan, Andrew F.

AU - Weissler, Mark C.

AU - Luo, Jingchun

AU - Romkes, Marjorie

AU - Buch, Shama

AU - Nukui, Tomoko

AU - Franceschi, Silvia

AU - Herrero, Rolando

AU - Talamini, Renato

AU - Kelsey, Karl T.

AU - Christensen, Brock

AU - McClean, Michael D.

AU - Lacko, Martin

AU - Manni, Johannes J.

AU - Peters, Wilbert H.M.

AU - Lubiński, Jan

AU - Trubicka, Joanna

AU - Lener, Marcin

AU - Muscat, Joshua E.

AU - Lazarus, Philip

AU - Wei, Qingyi

AU - Sturgis, Erich M.

AU - Zhang, Zuo Feng

AU - Chang, Shen Chih

AU - Wang, Renyi

AU - Schwartz, Stephen M.

AU - Chen, Chu

AU - Benhamou, Simone

AU - Lagiou, Pagona

AU - Holcátová, Ivana

AU - Richiardi, Lorenzo

AU - Kjaerheim, Kristina

AU - Agudo, Antonio

AU - Castellsagué, Xavier

AU - Macfarlane, Tatiana V.

AU - Barzan, Luigi

AU - Canova, Cristina

AU - Thakker, Nalin S.

AU - Conway, David I.

AU - Znaor, Ariana

AU - Healy, Claire M.

AU - Ahrens, Wolfgang

AU - Zaridze, David

AU - Szeszenia-Dabrowska, Neonila

AU - Lissowska, Jolanta

AU - Fabianova, Eleonora

AU - Bucur, Alexandru

AU - Bencko, Vladimir

AU - Foretova, Lenka

AU - Janout, Vladimir

AU - Curado, Maria Paula

AU - Koifman, Sergio

AU - Menezes, Ana

AU - Wünsch-Filho, Victor

AU - Eluf-Neto, José

AU - Fernandez, Leticia

AU - Boccia, Stefania

AU - Hashibe, Mia

AU - Hayes, Richard B.

AU - Boffetta, Paolo

AU - Brennan, Paul

AU - McKay, James D.

PY - 2011/4

Y1 - 2011/4

N2 - Background: Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx, and esophagus) in women (OR = 1.24, P = 0.003) with little effect in men (OR = 1.04, P = 0.35). Methods: In a coordinated genotyping study within the International Head and Neck Cancer Epidemiology (INHANCE) consortium, we have sought to replicate these findings in an additional 4,604 cases and 6,239 controls from 10 independent UADT cancer case - control studies. Results: rs16969968 was again associated with UADT cancers in women (OR = 1.21, 95% CI = 1.08-1.36, P = 0.001) and a similar lack of observed effect in men [OR = 1.02, 95% CI = 0.95-1.09, P = 0.66; P-heterogeneity (P het) = 0.01]. In a pooled analysis of the original and current studies, totaling 8,572 UADT cancer cases and 11,558 controls, the association was observed among females (OR = 1.22, 95% CI = 1.12-1.34, P = 7 × 10 -6) but not males (OR = 1.02, 95% CI = 0.97-1.08, P = 0.35; P het = 6 × 10-4). There was little evidence for a sex difference in the association between this variant and cigarettes smoked per day, with male and female rs16969968 variant carriers smoking approximately the same amount more in the 11,991 ever smokers in the pooled analysis of the 14 studies (Phet = 0.86). Conclusions: This study has confirmed a sex difference in the association between the 15q25 variant rs16969968 and UADT cancers. Impact: Further research is warranted to elucidate the mechanisms underlying these observations.

AB - Background: Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx, and esophagus) in women (OR = 1.24, P = 0.003) with little effect in men (OR = 1.04, P = 0.35). Methods: In a coordinated genotyping study within the International Head and Neck Cancer Epidemiology (INHANCE) consortium, we have sought to replicate these findings in an additional 4,604 cases and 6,239 controls from 10 independent UADT cancer case - control studies. Results: rs16969968 was again associated with UADT cancers in women (OR = 1.21, 95% CI = 1.08-1.36, P = 0.001) and a similar lack of observed effect in men [OR = 1.02, 95% CI = 0.95-1.09, P = 0.66; P-heterogeneity (P het) = 0.01]. In a pooled analysis of the original and current studies, totaling 8,572 UADT cancer cases and 11,558 controls, the association was observed among females (OR = 1.22, 95% CI = 1.12-1.34, P = 7 × 10 -6) but not males (OR = 1.02, 95% CI = 0.97-1.08, P = 0.35; P het = 6 × 10-4). There was little evidence for a sex difference in the association between this variant and cigarettes smoked per day, with male and female rs16969968 variant carriers smoking approximately the same amount more in the 11,991 ever smokers in the pooled analysis of the 14 studies (Phet = 0.86). Conclusions: This study has confirmed a sex difference in the association between the 15q25 variant rs16969968 and UADT cancers. Impact: Further research is warranted to elucidate the mechanisms underlying these observations.

UR - https://www.scopus.com/pages/publications/79955799786

U2 - 10.1158/1055-9965.EPI-10-1008

DO - 10.1158/1055-9965.EPI-10-1008

M3 - Article

C2 - 21335511

AN - SCOPUS:79955799786

SN - 1055-9965

VL - 20

SP - 658

EP - 664

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

IS - 4

ER -

A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers

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