A two-step chemical and circular dichroic method for assigning the absolute configurations of sphingosines

V. Dirsch; J. Frederico; N. Zhao; G. Cai; Y. Chen; S. Vunnam; J. Odingo; H. Pu; K. Nakanishi; N. Berova; D. Liotta; A. Bielawska; Y. Hannun

A two-step chemical and circular dichroic method for assigning the absolute configurations of sphingosines

V. Dirsch
, J. Frederico
, N. Zhao
, G. Cai
, Y. Chen
, S. Vunnam
, J. Odingo
, H. Pu
, K. Nakanishi
, N. Berova
, D. Liotta
, A. Bielawska
, Y. Hannun

Cancer Center

Columbia University

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Breakdown products of sphingolipids are involved in cell regulation and exhibit a wide variety of activities related to signal transduction. The backbone of sphingolipids are the sphingosines which have two stereogenic centers. A general, rapid, chemical/chiroptical micromethod based on the bichromophoric CD exciton chirality principle was developed to distinguish all four possible stereoisomers nonambiguously at a level of ca. 1 microgram.

Original language	English
Pages (from-to)	4959-4962
Number of pages	4
Journal	Tetrahedron Letters
Volume	36
Issue number	28
State	Published - 1995

Cite this

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title = "A two-step chemical and circular dichroic method for assigning the absolute configurations of sphingosines",

abstract = "Breakdown products of sphingolipids are involved in cell regulation and exhibit a wide variety of activities related to signal transduction. The backbone of sphingolipids are the sphingosines which have two stereogenic centers. A general, rapid, chemical/chiroptical micromethod based on the bichromophoric CD exciton chirality principle was developed to distinguish all four possible stereoisomers nonambiguously at a level of ca. 1 microgram.",

author = "V. Dirsch and J. Frederico and N. Zhao and G. Cai and Y. Chen and S. Vunnam and J. Odingo and H. Pu and K. Nakanishi and N. Berova and D. Liotta and A. Bielawska and Y. Hannun",

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T1 - A two-step chemical and circular dichroic method for assigning the absolute configurations of sphingosines

AU - Dirsch, V.

AU - Frederico, J.

AU - Zhao, N.

AU - Cai, G.

AU - Chen, Y.

AU - Vunnam, S.

AU - Odingo, J.

AU - Pu, H.

AU - Nakanishi, K.

AU - Berova, N.

AU - Liotta, D.

AU - Bielawska, A.

AU - Hannun, Y.

PY - 1995

Y1 - 1995

N2 - Breakdown products of sphingolipids are involved in cell regulation and exhibit a wide variety of activities related to signal transduction. The backbone of sphingolipids are the sphingosines which have two stereogenic centers. A general, rapid, chemical/chiroptical micromethod based on the bichromophoric CD exciton chirality principle was developed to distinguish all four possible stereoisomers nonambiguously at a level of ca. 1 microgram.

AB - Breakdown products of sphingolipids are involved in cell regulation and exhibit a wide variety of activities related to signal transduction. The backbone of sphingolipids are the sphingosines which have two stereogenic centers. A general, rapid, chemical/chiroptical micromethod based on the bichromophoric CD exciton chirality principle was developed to distinguish all four possible stereoisomers nonambiguously at a level of ca. 1 microgram.

UR - https://www.scopus.com/pages/publications/85047668742

M3 - Article

AN - SCOPUS:85047668742

SN - 0040-4039

VL - 36

SP - 4959

EP - 4962

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 28

ER -

A two-step chemical and circular dichroic method for assigning the absolute configurations of sphingosines

Abstract

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