A two-step chemical and circular dichroic method for assigning the absolute configurations of sphingosines

Verena Dirsch; Justin Frederico; Zhao Ning Zhao; Cai Guolin Cai; Chen Yanqui Chen; Satyanarayana Vunnam; Joshua Odingo; Pu Hyan Pu; Koji Nakanishi; Nina Berova; Dennis Liotta; Alicja Bielawska; Yusuf Hannun

doi:10.1016/0040-4039(95)00998-r

A two-step chemical and circular dichroic method for assigning the absolute configurations of sphingosines

Verena Dirsch
, Justin Frederico
, Zhao Ning Zhao
, Cai Guolin Cai
, Chen Yanqui Chen
, Satyanarayana Vunnam
, Joshua Odingo
, Pu Hyan Pu
, Koji Nakanishi
, Nina Berova
, Dennis Liotta
, Alicja Bielawska
, Yusuf Hannun

Cancer Center

Columbia University
Emory University
Duke University

Research output: Contribution to journal › Article › peer-review

Abstract

Breakdown products of sphingolipids are involved in cell regulaion and exhibit a wide variety of activities related to signal transduction. The backbone of sphingolipids are the sphingosines which have two stereogenic centers. A general, rapid, chemical/chiroptical micromethod based on the bichromophoric CD exciton chirality principle was developed to distinguish all four possible stereoisomers nonambiguously at a level of ca. 1 microgram.

Original language	English
Pages (from-to)	4959-4962
Number of pages	4
Journal	Tetrahedron Letters
Volume	36
Issue number	28
DOIs	https://doi.org/10.1016/0040-4039(95)00998-r
State	Published - Jul 10 1995

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Dirsch, V., Frederico, J., Ning Zhao, Z., Guolin Cai, C., Yanqui Chen, C., Vunnam, S., Odingo, J., Hyan Pu, P., Nakanishi, K., Berova, N., Liotta, D., Bielawska, A., & Hannun, Y. (1995). A two-step chemical and circular dichroic method for assigning the absolute configurations of sphingosines. Tetrahedron Letters, 36(28), 4959-4962. https://doi.org/10.1016/0040-4039(95)00998-r

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title = "A two-step chemical and circular dichroic method for assigning the absolute configurations of sphingosines",

abstract = "Breakdown products of sphingolipids are involved in cell regulaion and exhibit a wide variety of activities related to signal transduction. The backbone of sphingolipids are the sphingosines which have two stereogenic centers. A general, rapid, chemical/chiroptical micromethod based on the bichromophoric CD exciton chirality principle was developed to distinguish all four possible stereoisomers nonambiguously at a level of ca. 1 microgram.",

author = "Verena Dirsch and Justin Frederico and \{Ning Zhao\}, Zhao and \{Guolin Cai\}, Cai and \{Yanqui Chen\}, Chen and Satyanarayana Vunnam and Joshua Odingo and \{Hyan Pu\}, Pu and Koji Nakanishi and Nina Berova and Dennis Liotta and Alicja Bielawska and Yusuf Hannun",

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doi = "10.1016/0040-4039(95)00998-r",

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Dirsch, V, Frederico, J, Ning Zhao, Z, Guolin Cai, C, Yanqui Chen, C, Vunnam, S, Odingo, J, Hyan Pu, P, Nakanishi, K, Berova, N, Liotta, D, Bielawska, A & Hannun, Y 1995, 'A two-step chemical and circular dichroic method for assigning the absolute configurations of sphingosines', Tetrahedron Letters, vol. 36, no. 28, pp. 4959-4962. https://doi.org/10.1016/0040-4039(95)00998-r

TY - JOUR

T1 - A two-step chemical and circular dichroic method for assigning the absolute configurations of sphingosines

AU - Dirsch, Verena

AU - Frederico, Justin

AU - Ning Zhao, Zhao

AU - Guolin Cai, Cai

AU - Yanqui Chen, Chen

AU - Vunnam, Satyanarayana

AU - Odingo, Joshua

AU - Hyan Pu, Pu

AU - Nakanishi, Koji

AU - Berova, Nina

AU - Liotta, Dennis

AU - Bielawska, Alicja

AU - Hannun, Yusuf

PY - 1995/7/10

Y1 - 1995/7/10

N2 - Breakdown products of sphingolipids are involved in cell regulaion and exhibit a wide variety of activities related to signal transduction. The backbone of sphingolipids are the sphingosines which have two stereogenic centers. A general, rapid, chemical/chiroptical micromethod based on the bichromophoric CD exciton chirality principle was developed to distinguish all four possible stereoisomers nonambiguously at a level of ca. 1 microgram.

AB - Breakdown products of sphingolipids are involved in cell regulaion and exhibit a wide variety of activities related to signal transduction. The backbone of sphingolipids are the sphingosines which have two stereogenic centers. A general, rapid, chemical/chiroptical micromethod based on the bichromophoric CD exciton chirality principle was developed to distinguish all four possible stereoisomers nonambiguously at a level of ca. 1 microgram.

UR - https://www.scopus.com/pages/publications/105006971316

U2 - 10.1016/0040-4039(95)00998-r

DO - 10.1016/0040-4039(95)00998-r

M3 - Article

AN - SCOPUS:105006971316

SN - 0040-4039

VL - 36

SP - 4959

EP - 4962

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 28

ER -

A two-step chemical and circular dichroic method for assigning the absolute configurations of sphingosines

Abstract

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