AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment

Evanthia T. Roussos; Zuzana Keckesova; John D. Haley; David M. Epstein; Robert A. Weinberg; John S. Condeelis

doi:10.1158/0008-5472.CAN-10-1208

AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment

Evanthia T. Roussos
, Zuzana Keckesova
, John D. Haley
, David M. Epstein
, Robert A. Weinberg
, John S. Condeelis

Pathology

Albert Einstein College of Medicine
Massachusetts Institute of Technology
OSI Pharmaceuticals Inc.

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

Epithelial-mesenchymal transition (EMT) is a developmental program implicated in cancer progression and was the subject of the 2010 AACR meeting on the topic of EMT and Cancer Progression and Treatment held on February 28 to March 2 in Arlington, Virginia. A review of the involvement of EMT in gastrulation, organogenesis, carcinogenesis, and metastatic progression elucidated the overlap of EMT in these physiologic and pathologic conditions. Both novel and traditional markers of cells undergoing EMT were discussed and compared with features used to define cancer stem cells. Importantly, these defining characteristics of cells undergoing EMT were discussed in the context of therapeutic and prognostic developments.

Original language	English
Pages (from-to)	7360-7364
Number of pages	5
Journal	Cancer Research
Volume	70
Issue number	19
DOIs	https://doi.org/10.1158/0008-5472.CAN-10-1208
State	Published - Oct 1 2010

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10.1158/0008-5472.CAN-10-1208

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title = "AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment",

abstract = "Epithelial-mesenchymal transition (EMT) is a developmental program implicated in cancer progression and was the subject of the 2010 AACR meeting on the topic of EMT and Cancer Progression and Treatment held on February 28 to March 2 in Arlington, Virginia. A review of the involvement of EMT in gastrulation, organogenesis, carcinogenesis, and metastatic progression elucidated the overlap of EMT in these physiologic and pathologic conditions. Both novel and traditional markers of cells undergoing EMT were discussed and compared with features used to define cancer stem cells. Importantly, these defining characteristics of cells undergoing EMT were discussed in the context of therapeutic and prognostic developments.",

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AU - Roussos, Evanthia T.

AU - Keckesova, Zuzana

AU - Haley, John D.

AU - Epstein, David M.

AU - Weinberg, Robert A.

AU - Condeelis, John S.

PY - 2010/10/1

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AB - Epithelial-mesenchymal transition (EMT) is a developmental program implicated in cancer progression and was the subject of the 2010 AACR meeting on the topic of EMT and Cancer Progression and Treatment held on February 28 to March 2 in Arlington, Virginia. A review of the involvement of EMT in gastrulation, organogenesis, carcinogenesis, and metastatic progression elucidated the overlap of EMT in these physiologic and pathologic conditions. Both novel and traditional markers of cells undergoing EMT were discussed and compared with features used to define cancer stem cells. Importantly, these defining characteristics of cells undergoing EMT were discussed in the context of therapeutic and prognostic developments.

UR - https://www.scopus.com/pages/publications/77957375136

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JO - Cancer Research

JF - Cancer Research

IS - 19

ER -

AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment

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