Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib

Ariel Leyte-Vidal; Rosa Anna DeFilippis; Ian R. Outhwaite; Isabelle Kwan; Ji Young Lee; Carlyn Leavitt; Kaeli B. Miller; Delphine Rea; Aziz M. Rangwala; Kevin Lou; Suhana Patel; Ailin Alvarez; Kevan M. Shokat; Ivet Bahar; Markus A. Seeliger; Neil P. Shah

doi:10.1038/s41375-024-02353-0

Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib

Ariel Leyte-Vidal
, Rosa Anna DeFilippis
, Ian R. Outhwaite
, Isabelle Kwan
, Ji Young Lee
, Carlyn Leavitt
, Kaeli B. Miller
, Delphine Rea
, Aziz M. Rangwala
, Kevin Lou
, Suhana Patel
, Ailin Alvarez
, Kevan M. Shokat
, Ivet Bahar
, Markus A. Seeliger
, Neil P. Shah

University of California at San Francisco
University of Miami
Stony Brook University
Université Paris Cité
University of California at Berkeley

Research output: Contribution to journal › Letter › peer-review

11 Scopus citations

Original language	English
Pages (from-to)	2046-2050
Number of pages	5
Journal	Leukemia
Volume	38
Issue number	9
DOIs	https://doi.org/10.1038/s41375-024-02353-0
State	Published - Sep 2024

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Leyte-Vidal, A., DeFilippis, R. A., Outhwaite, I. R., Kwan, I., Lee, J. Y., Leavitt, C., Miller, K. B., Rea, D., Rangwala, A. M., Lou, K., Patel, S., Alvarez, A., Shokat, K. M., Bahar, I., Seeliger, M. A., & Shah, N. P. (2024). Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib. Leukemia, 38(9), 2046-2050. https://doi.org/10.1038/s41375-024-02353-0

@article{2fd8db5b0ae842f0ae3577f8476667f5,

title = "Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib",

author = "Ariel Leyte-Vidal and DeFilippis, \{Rosa Anna\} and Outhwaite, \{Ian R.\} and Isabelle Kwan and Lee, \{Ji Young\} and Carlyn Leavitt and Miller, \{Kaeli B.\} and Delphine Rea and Rangwala, \{Aziz M.\} and Kevin Lou and Suhana Patel and Ailin Alvarez and Shokat, \{Kevan M.\} and Ivet Bahar and Seeliger, \{Markus A.\} and Shah, \{Neil P.\}",

year = "2024",

month = sep,

doi = "10.1038/s41375-024-02353-0",

language = "English",

volume = "38",

pages = "2046--2050",

journal = "Leukemia",

issn = "0887-6924",

number = "9",

}

Leyte-Vidal, A, DeFilippis, RA, Outhwaite, IR, Kwan, I, Lee, JY, Leavitt, C, Miller, KB, Rea, D, Rangwala, AM, Lou, K, Patel, S, Alvarez, A, Shokat, KM, Bahar, I , Seeliger, MA & Shah, NP 2024, 'Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib', Leukemia, vol. 38, no. 9, pp. 2046-2050. https://doi.org/10.1038/s41375-024-02353-0

TY - JOUR

T1 - Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib

AU - Leyte-Vidal, Ariel

AU - DeFilippis, Rosa Anna

AU - Outhwaite, Ian R.

AU - Kwan, Isabelle

AU - Lee, Ji Young

AU - Leavitt, Carlyn

AU - Miller, Kaeli B.

AU - Rea, Delphine

AU - Rangwala, Aziz M.

AU - Lou, Kevin

AU - Patel, Suhana

AU - Alvarez, Ailin

AU - Shokat, Kevan M.

AU - Bahar, Ivet

AU - Seeliger, Markus A.

AU - Shah, Neil P.

PY - 2024/9

Y1 - 2024/9

UR - https://www.scopus.com/pages/publications/85200141065

U2 - 10.1038/s41375-024-02353-0

DO - 10.1038/s41375-024-02353-0

M3 - Letter

C2 - 39085402

AN - SCOPUS:85200141065

SN - 0887-6924

VL - 38

SP - 2046

EP - 2050

JO - Leukemia

JF - Leukemia

IS - 9

ER -

Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib

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