Acetaldehyde: The Mutagenic Activity of Its Photooxidation Products

Paul B. Shepson; Tadeusz E. Kleindienst; Edward O. Edney; Chris M. Nero; Larry T. Cupitt; Larry D. Claxton

doi:10.1021/es00152a007

Acetaldehyde: The Mutagenic Activity of Its Photooxidation Products

Paul B. Shepson
, Tadeusz E. Kleindienst
, Edward O. Edney
, Chris M. Nero
, Larry T. Cupitt
, Larry D. Claxton

Office of the Dean SOMAS

United States Environmental Protection Agency

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

We exposed Salmonella typhimurium strain TA100 to the gas-phase products of the photooxidation of acetaldehyde by using the effluent from a flow-mode smog chamber. The total mutagenic activity of the photooxidation products under simulated atmospheric reaction conditions was measured. Significant mutagenic activity was observed when the reaction time was long and considerable concentrations of ozone and organic peroxy-type products were present and when the reaction time was short and the major products were formaldehyde and peroxyacetyl nitrate (PAN). The photooxidation of acetaldehyde is shown to account for a significant fraction of the mutagenic activity observed from the photooxidation of propylene. It was found that most of the observed response can be accounted for by the presence of PAN in the reaction chamber. The apparent mutagenic activity of PAN in these experiments was found to be considerably larger than in previous laboratory measurements.

Original language	English
Pages (from-to)	1008-1013
Number of pages	6
Journal	Environmental Science and Technology
Volume	20
Issue number	10
DOIs	https://doi.org/10.1021/es00152a007
State	Published - 1986

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title = "Acetaldehyde: The Mutagenic Activity of Its Photooxidation Products",

abstract = "We exposed Salmonella typhimurium strain TA100 to the gas-phase products of the photooxidation of acetaldehyde by using the effluent from a flow-mode smog chamber. The total mutagenic activity of the photooxidation products under simulated atmospheric reaction conditions was measured. Significant mutagenic activity was observed when the reaction time was long and considerable concentrations of ozone and organic peroxy-type products were present and when the reaction time was short and the major products were formaldehyde and peroxyacetyl nitrate (PAN). The photooxidation of acetaldehyde is shown to account for a significant fraction of the mutagenic activity observed from the photooxidation of propylene. It was found that most of the observed response can be accounted for by the presence of PAN in the reaction chamber. The apparent mutagenic activity of PAN in these experiments was found to be considerably larger than in previous laboratory measurements.",

author = "Shepson, \{Paul B.\} and Kleindienst, \{Tadeusz E.\} and Edney, \{Edward O.\} and Nero, \{Chris M.\} and Cupitt, \{Larry T.\} and Claxton, \{Larry D.\}",

year = "1986",

doi = "10.1021/es00152a007",

language = "English",

volume = "20",

pages = "1008--1013",

journal = "Environmental Science and Technology",

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TY - JOUR

T1 - Acetaldehyde

T2 - The Mutagenic Activity of Its Photooxidation Products

AU - Shepson, Paul B.

AU - Kleindienst, Tadeusz E.

AU - Edney, Edward O.

AU - Nero, Chris M.

AU - Cupitt, Larry T.

AU - Claxton, Larry D.

PY - 1986

Y1 - 1986

N2 - We exposed Salmonella typhimurium strain TA100 to the gas-phase products of the photooxidation of acetaldehyde by using the effluent from a flow-mode smog chamber. The total mutagenic activity of the photooxidation products under simulated atmospheric reaction conditions was measured. Significant mutagenic activity was observed when the reaction time was long and considerable concentrations of ozone and organic peroxy-type products were present and when the reaction time was short and the major products were formaldehyde and peroxyacetyl nitrate (PAN). The photooxidation of acetaldehyde is shown to account for a significant fraction of the mutagenic activity observed from the photooxidation of propylene. It was found that most of the observed response can be accounted for by the presence of PAN in the reaction chamber. The apparent mutagenic activity of PAN in these experiments was found to be considerably larger than in previous laboratory measurements.

AB - We exposed Salmonella typhimurium strain TA100 to the gas-phase products of the photooxidation of acetaldehyde by using the effluent from a flow-mode smog chamber. The total mutagenic activity of the photooxidation products under simulated atmospheric reaction conditions was measured. Significant mutagenic activity was observed when the reaction time was long and considerable concentrations of ozone and organic peroxy-type products were present and when the reaction time was short and the major products were formaldehyde and peroxyacetyl nitrate (PAN). The photooxidation of acetaldehyde is shown to account for a significant fraction of the mutagenic activity observed from the photooxidation of propylene. It was found that most of the observed response can be accounted for by the presence of PAN in the reaction chamber. The apparent mutagenic activity of PAN in these experiments was found to be considerably larger than in previous laboratory measurements.

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U2 - 10.1021/es00152a007

DO - 10.1021/es00152a007

M3 - Article

AN - SCOPUS:0022554187

SN - 0013-936X

VL - 20

SP - 1008

EP - 1013

JO - Environmental Science and Technology

JF - Environmental Science and Technology

IS - 10

ER -

Acetaldehyde: The Mutagenic Activity of Its Photooxidation Products

Abstract

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