Activation of transposable elements during aging and neuronal decline in Drosophila

Wanhe Li; Lisa Prazak; Nabanita Chatterjee; Servan Grüninger; Lisa Krug; Delphine Theodorou; Josh Dubnau

doi:10.1038/nn.3368

Activation of transposable elements during aging and neuronal decline in Drosophila

Wanhe Li
, Lisa Prazak
, Nabanita Chatterjee
, Servan Grüninger
, Lisa Krug
, Delphine Theodorou
, Josh Dubnau

Anesthesiology

Cold Spring Harbor Laboratory
Stony Brook University
University of Zurich
Université Paris Cité

Research output: Contribution to journal › Article › peer-review

278 Scopus citations

Abstract

We found that several transposable elements were highly active in Drosophila brain during normal aging. In addition, we found that mutations in Drosophila Argonaute 2 (Ago2) resulted in exacerbated transposon expression in the brain, progressive and age-dependent memory impairment, and shortened lifespan. These findings suggest that transposon activation may contribute to age-dependent loss of neuronal function.

Original language	English
Pages (from-to)	529-531
Number of pages	3
Journal	Nature Neuroscience
Volume	16
Issue number	5
DOIs	https://doi.org/10.1038/nn.3368
State	Published - May 2013

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abstract = "We found that several transposable elements were highly active in Drosophila brain during normal aging. In addition, we found that mutations in Drosophila Argonaute 2 (Ago2) resulted in exacerbated transposon expression in the brain, progressive and age-dependent memory impairment, and shortened lifespan. These findings suggest that transposon activation may contribute to age-dependent loss of neuronal function.",

author = "Wanhe Li and Lisa Prazak and Nabanita Chatterjee and Servan Gr{\"u}ninger and Lisa Krug and Delphine Theodorou and Josh Dubnau",

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AU - Krug, Lisa

AU - Theodorou, Delphine

AU - Dubnau, Josh

PY - 2013/5

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AB - We found that several transposable elements were highly active in Drosophila brain during normal aging. In addition, we found that mutations in Drosophila Argonaute 2 (Ago2) resulted in exacerbated transposon expression in the brain, progressive and age-dependent memory impairment, and shortened lifespan. These findings suggest that transposon activation may contribute to age-dependent loss of neuronal function.

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DO - 10.1038/nn.3368

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Activation of transposable elements during aging and neuronal decline in Drosophila

Abstract

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