Abstract
Melanocortin-1 (MC1) receptor is an attractive melanoma-specific target over-expressed on the surface of melanoma cells. Alpha-melanocyte stimulating hormone (alpha-MSH) peptide analogues can specifically bind MC1 receptors with nanomolar binding affinities, making alpha-MSH peptide analogues very promising candidates for developing effective melanoma-specific imaging probes. This review highlights the strategies being used to design alpha-MSH peptide radiopharmaceuticals to target MC1 receptors and some recent developments of radiolabeled alpha-MSH peptide analogues for melanoma imaging.
| Original language | English |
|---|---|
| Pages (from-to) | 4514-4524 |
| Number of pages | 11 |
| Journal | Frontiers in bioscience : a journal and virtual library |
| Volume | 12 |
| Issue number | 12 |
| DOIs | |
| State | Published - May 1 2007 |
Keywords
- Alpha-melanocyte stimulating hormone peptide
- Melanoma imaging
- Melanorcortin-1 receptor
- Review
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