@inbook{47a29643b87743889a7e8447404e55a5,
title = "Alterations of Serotonin Transmission in Schizophrenia",
abstract = "A role for serotonin alterations in the pathophysiology of schizophrenia has long been suspected because of the psychotogenic effects of serotonergic agonists and the therapeutic effects of 5-HT2 antagonism. This chapter is a review of the evidence derived from pharmacological studies, postmortem, and imaging studies that have assessed the role of serotonin transmission in schizophrenia. While a clear picture of specific serotonergic alterations in schizophrenia has not emerged despite much research, this review reinforces a modulatory role of serotonergic agents on dopamine transmission in schizophrenia, which may contribute to the therapeutic effects of atypical antipsychotics.",
author = "Anissa Abi-Dargham",
year = "2007",
doi = "10.1016/S0074-7742(06)78005-9",
language = "English",
isbn = "0123737370",
series = "International Review of Neurobiology",
pages = "133--164",
editor = "Anissa AbiDargham and Olivier Guillin",
booktitle = "Integrating the Neurobiology of Schizophrenia",
}