Aminocyclitols as pharmacological chaperones for glucocerebrosidase, a defective enzyme in Gaucher disease

Meritxell Egido-Gabás; Daniel Canals; Josefina Casas; Amadeu Llebaria; Antonio Delgado

doi:10.1002/cmdc.200700061

Aminocyclitols as pharmacological chaperones for glucocerebrosidase, a defective enzyme in Gaucher disease

Meritxell Egido-Gabás
, Daniel Canals
, Josefina Casas
, Amadeu Llebaria
, Antonio Delgado

Medical Oncology

CSIC
University of Barcelona

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

(Chemical Equation Presented) New therapeutic strategies against sphingolipidoses: a series of aminocyclitols described herein represent new structural types of compounds with promising chaperone-like properties on GlcCerase, a defective enzyme associated with Gaucher disease.

Original language	English
Pages (from-to)	992-994
Number of pages	3
Journal	ChemMedChem
Volume	2
Issue number	7
DOIs	https://doi.org/10.1002/cmdc.200700061
State	Published - Jul 9 2007

Keywords

Chaperones
Cyclitols
Gaucher
Glucocerebrosidase
Glycolipids

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10.1002/cmdc.200700061

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title = "Aminocyclitols as pharmacological chaperones for glucocerebrosidase, a defective enzyme in Gaucher disease",

abstract = "(Chemical Equation Presented) New therapeutic strategies against sphingolipidoses: a series of aminocyclitols described herein represent new structural types of compounds with promising chaperone-like properties on GlcCerase, a defective enzyme associated with Gaucher disease.",

keywords = "Chaperones, Cyclitols, Gaucher, Glucocerebrosidase, Glycolipids",

author = "Meritxell Egido-Gab{\'a}s and Daniel Canals and Josefina Casas and Amadeu Llebaria and Antonio Delgado",

year = "2007",

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AU - Egido-Gabás, Meritxell

AU - Canals, Daniel

AU - Casas, Josefina

AU - Llebaria, Amadeu

AU - Delgado, Antonio

PY - 2007/7/9

Y1 - 2007/7/9

N2 - (Chemical Equation Presented) New therapeutic strategies against sphingolipidoses: a series of aminocyclitols described herein represent new structural types of compounds with promising chaperone-like properties on GlcCerase, a defective enzyme associated with Gaucher disease.

AB - (Chemical Equation Presented) New therapeutic strategies against sphingolipidoses: a series of aminocyclitols described herein represent new structural types of compounds with promising chaperone-like properties on GlcCerase, a defective enzyme associated with Gaucher disease.

KW - Chaperones

KW - Cyclitols

KW - Gaucher

KW - Glucocerebrosidase

KW - Glycolipids

UR - https://www.scopus.com/pages/publications/34548540634

U2 - 10.1002/cmdc.200700061

DO - 10.1002/cmdc.200700061

M3 - Article

C2 - 17479993

AN - SCOPUS:34548540634

SN - 1860-7179

VL - 2

SP - 992

EP - 994

JO - ChemMedChem

JF - ChemMedChem

IS - 7

ER -

Aminocyclitols as pharmacological chaperones for glucocerebrosidase, a defective enzyme in Gaucher disease

Abstract

Keywords

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