Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation

T. Canli; E. Congdon; L. Gutknecht; R. T. Constable; K. P. Lesch

doi:10.1007/s00702-005-0391-4

Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation

T. Canli
, E. Congdon
, L. Gutknecht
, R. T. Constable
, K. P. Lesch

Psychology

Stony Brook University
University of Würzburg
Yale University

Research output: Contribution to journal › Article › peer-review

172 Scopus citations

Abstract

The tryptophan hydroxylase-2 gene (TPH2) codes for the enzyme of serotonin (5-HT) synthesis in the brain and variation of TPH2 has been implicated in disorders of emotion regulation. Here, we used functional magnetic resonance imaging (fMRI) to demonstrate that a potentially functional variant of TPH2 modulates amygdala responsiveness to emotional stimuli of both negative and positive valence.

Original language	English
Pages (from-to)	1479-1485
Number of pages	7
Journal	Journal of Neural Transmission
Volume	112
Issue number	11
DOIs	https://doi.org/10.1007/s00702-005-0391-4
State	Published - Nov 2005

Keywords

Amygdala
Functional imaging
Tryptophan hydroxylase-2 gene

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10.1007/s00702-005-0391-4

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abstract = "The tryptophan hydroxylase-2 gene (TPH2) codes for the enzyme of serotonin (5-HT) synthesis in the brain and variation of TPH2 has been implicated in disorders of emotion regulation. Here, we used functional magnetic resonance imaging (fMRI) to demonstrate that a potentially functional variant of TPH2 modulates amygdala responsiveness to emotional stimuli of both negative and positive valence.",

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AU - Lesch, K. P.

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KW - Amygdala

KW - Functional imaging

KW - Tryptophan hydroxylase-2 gene

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Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation

Abstract

Keywords

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