Amyloid plaque imaging agent [c-11]-6-oh-bta-1: biodistribution and radiation dosimetry in baboon

Ramin V. Parsey; Levi O. Sokol; Marie José Bélanger; J. S.Dileep Kumar; Norman R. Simpson; Theodore Wang; Mali Pratap; Ronald L. Van Heertum; J. John Mann

doi:10.1097/00006231-200510000-00005

Amyloid plaque imaging agent [c-11]-6-oh-bta-1: biodistribution and radiation dosimetry in baboon

Ramin V. Parsey
, Levi O. Sokol
, Marie José Bélanger
, J. S.Dileep Kumar
, Norman R. Simpson
, Theodore Wang
, Mali Pratap
, Ronald L. Van Heertum
, J. John Mann

Psychiatry

Columbia University

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The amyloid neuritic plaque is considered to be a toxic collection of amyloid-ß protein found in brain tissue in Alzheimer's disease. A neutral analogue of the amyloid-binding thioflavin-T (BTA), has been radiolabeled as [C-11]-6-OH-BTA-1. It crosses the blood brain barrier, and is a promising tracer for imaging plaques in vivo using positron emission tomography. We now report the biodistribution and dosimetry of [C-11]-6-OH-BTA-1 in baboons.

Original language	English
Pages (from-to)	875-880
Number of pages	6
Journal	Nuclear Medicine Communications
Volume	26
Issue number	10
DOIs	https://doi.org/10.1097/00006231-200510000-00005
State	Published - Oct 2005

Keywords

Amyloid
BTA
Positron emission tomography
Radiation dosimetry

Access to Document

10.1097/00006231-200510000-00005

Cite this

@article{42204a11c1bb4efd81d495850e6660b9,

title = "Amyloid plaque imaging agent [c-11]-6-oh-bta-1: biodistribution and radiation dosimetry in baboon",

abstract = "The amyloid neuritic plaque is considered to be a toxic collection of amyloid-{\ss} protein found in brain tissue in Alzheimer's disease. A neutral analogue of the amyloid-binding thioflavin-T (BTA), has been radiolabeled as [C-11]-6-OH-BTA-1. It crosses the blood brain barrier, and is a promising tracer for imaging plaques in vivo using positron emission tomography. We now report the biodistribution and dosimetry of [C-11]-6-OH-BTA-1 in baboons.",

keywords = "Amyloid, BTA, Positron emission tomography, Radiation dosimetry",

author = "Parsey, \{Ramin V.\} and Sokol, \{Levi O.\} and B{\'e}langer, \{Marie Jos{\'e}\} and Kumar, \{J. S.Dileep\} and Simpson, \{Norman R.\} and Theodore Wang and Mali Pratap and \{Van Heertum\}, \{Ronald L.\} and \{John Mann\}, J.",

year = "2005",

month = oct,

doi = "10.1097/00006231-200510000-00005",

language = "English",

volume = "26",

pages = "875--880",

journal = "Nuclear Medicine Communications",

issn = "0143-3636",

number = "10",

}

TY - JOUR

T1 - Amyloid plaque imaging agent [c-11]-6-oh-bta-1

T2 - biodistribution and radiation dosimetry in baboon

AU - Parsey, Ramin V.

AU - Sokol, Levi O.

AU - Bélanger, Marie José

AU - Kumar, J. S.Dileep

AU - Simpson, Norman R.

AU - Wang, Theodore

AU - Pratap, Mali

AU - Van Heertum, Ronald L.

AU - John Mann, J.

PY - 2005/10

Y1 - 2005/10

N2 - The amyloid neuritic plaque is considered to be a toxic collection of amyloid-ß protein found in brain tissue in Alzheimer's disease. A neutral analogue of the amyloid-binding thioflavin-T (BTA), has been radiolabeled as [C-11]-6-OH-BTA-1. It crosses the blood brain barrier, and is a promising tracer for imaging plaques in vivo using positron emission tomography. We now report the biodistribution and dosimetry of [C-11]-6-OH-BTA-1 in baboons.

AB - The amyloid neuritic plaque is considered to be a toxic collection of amyloid-ß protein found in brain tissue in Alzheimer's disease. A neutral analogue of the amyloid-binding thioflavin-T (BTA), has been radiolabeled as [C-11]-6-OH-BTA-1. It crosses the blood brain barrier, and is a promising tracer for imaging plaques in vivo using positron emission tomography. We now report the biodistribution and dosimetry of [C-11]-6-OH-BTA-1 in baboons.

KW - Amyloid

KW - BTA

KW - Positron emission tomography

KW - Radiation dosimetry

UR - https://www.scopus.com/pages/publications/26444596588

U2 - 10.1097/00006231-200510000-00005

DO - 10.1097/00006231-200510000-00005

M3 - Article

C2 - 16160646

AN - SCOPUS:26444596588

SN - 0143-3636

VL - 26

SP - 875

EP - 880

JO - Nuclear Medicine Communications

JF - Nuclear Medicine Communications

IS - 10

ER -

Amyloid plaque imaging agent [c-11]-6-oh-bta-1: biodistribution and radiation dosimetry in baboon

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this