TY - JOUR
T1 - An individual participant data meta-analysis of psychological interventions for preventing depression relapse
AU - Breedvelt, Josefien J.F.
AU - Karyotaki, Eirini
AU - Warren, Fiona C.
AU - Brouwer, Marlies E.
AU - Jermann, Françoise
AU - Hollandare, Fredrik
AU - Klein, Nicola
AU - de Jonge, Margo
AU - Klein, Daniel N.
AU - Farb, Norman
AU - Segal, Zindel
AU - Biesheuvel Leliefeld, Karolien E.M.
AU - Jarrett, Robin
AU - Vittengl, Jeffrey
AU - Thase, Michael
AU - Ma, Helen
AU - Kuyken, Willem
AU - Shallcross, Amanda J.
AU - van Heeringen, Cornelis
AU - Hoorelbeke, Kristof
AU - Koster, Ernst
AU - Williams, Mark
AU - Huijbers, Marloes J.
AU - Speckens, Anne
AU - Cuijpers, Pim
AU - van Oppen, Patricia
AU - Gilbody, Simon
AU - Bockting, Claudi L.
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/2
Y1 - 2024/2
N2 - Major depressive disorder is a leading cause of disability worldwide; identifying effective strategies to prevent depression relapse is crucial. This individual participant data meta-analysis addresses whether and for whom psychological interventions can be recommended for relapse prevention of major depressive disorder. One- and two-stage individual patient data meta-analyses were conducted on 14 randomized controlled trials (N = 1,720). The relapse risk over 12 months was substantially lower for those who received a psychological intervention versus treatment as usual, antidepressant medication, or evaluation-only control (hazard ratio, 0.60; 95% confidence interval, 0.48–0.74). The number of previous depression episodes moderated the treatment effect, with psychological interventions demonstrating greater efficacy for patients with three or more previous episodes. Our results suggest that adding psychological interventions to current treatment to prevent depression relapse is recommended. For patients at lower risk of relapse, less-intensive approaches may be indicated.
AB - Major depressive disorder is a leading cause of disability worldwide; identifying effective strategies to prevent depression relapse is crucial. This individual participant data meta-analysis addresses whether and for whom psychological interventions can be recommended for relapse prevention of major depressive disorder. One- and two-stage individual patient data meta-analyses were conducted on 14 randomized controlled trials (N = 1,720). The relapse risk over 12 months was substantially lower for those who received a psychological intervention versus treatment as usual, antidepressant medication, or evaluation-only control (hazard ratio, 0.60; 95% confidence interval, 0.48–0.74). The number of previous depression episodes moderated the treatment effect, with psychological interventions demonstrating greater efficacy for patients with three or more previous episodes. Our results suggest that adding psychological interventions to current treatment to prevent depression relapse is recommended. For patients at lower risk of relapse, less-intensive approaches may be indicated.
UR - https://www.scopus.com/pages/publications/85201071179
U2 - 10.1038/s44220-023-00178-x
DO - 10.1038/s44220-023-00178-x
M3 - Article
AN - SCOPUS:85201071179
SN - 2731-6076
VL - 2
SP - 154
EP - 163
JO - Nature Mental Health
JF - Nature Mental Health
IS - 2
M1 - 50
ER -