An MR compatible PET scanner based on RatCAP for small animal imaging at 9.4 T

S. H. Maramraju; S. Junnarkar; B. Ravindranath; S. Southekal; S. Stoll; S. D. Smith; W. Lenz; J. F. Pratte; M. Purschke; S. Rescia; S. Krishnamoorthy; P. Vaska; C. Woody; D. Schlyer

doi:10.1109/NSSMIC.2008.4774114

An MR compatible PET scanner based on RatCAP for small animal imaging at 9.4 T

S. H. Maramraju
, S. Junnarkar
, B. Ravindranath
, S. Southekal
, S. Stoll
, S. D. Smith
, W. Lenz
, J. F. Pratte
, M. Purschke
, S. Rescia
, S. Krishnamoorthy
, P. Vaska
, C. Woody
, D. Schlyer

Dept of Biomedical Engineering

Stony Brook University
Brookhaven National Laboratory

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

5 Scopus citations

Abstract

Combining PET and MRI technology in order to obtain simultaneous functional information with anatomical precision in vivo is of tremendous interest in the field of molecular imaging. PETIMRI imaging provides perfect anatomical and temporal coregistration of PET and MR images, along with clear delineation of tissue boundaries. An MR compatible PET scanner based on Rat Conscious Animal PET (RatCAP) is developed for simultaneous acquisition of PETIMRI images of the rat brain in a 9.4 T microMRI scanner. The PET tomograph is housed in a segmented G1O/copper case constructed with a copper coating thickness of 5 microns, to minimize the eddy currents and provide better RF shielding. Special RF coils were designed to fit inside the PET tomograph. A custom made GIO tube assembly was constructed for accurate positioning of the rat bed, RF coil and RatCAP. Simultaneous PETIMRI images of a rat striatum phantom were acquired in the 9.4 T microMRI with minimal interference between PET electronics and MRI. PET compatible RF quadrature coils are being constructed which are capable of providing rat brain images with improved SNR. The preliminary results show the feasibility of performing PET studies of rat brain and exploring the possibility of acquiring simultaneous PETIMRI whole body mouse images in the 9.4 T.

Original language	English
Title of host publication	2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008
Pages	3679-3682
Number of pages	4
DOIs	https://doi.org/10.1109/NSSMIC.2008.4774114
State	Published - 2008
Event	2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008 - Dresden, Germany Duration: Oct 19 2008 → Oct 25 2008

Publication series

Name	IEEE Nuclear Science Symposium Conference Record
ISSN (Print)	1095-7863

Conference

Conference	2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008
Country/Territory	Germany
City	Dresden
Period	10/19/08 → 10/25/08

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10.1109/NSSMIC.2008.4774114

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Maramraju, S. H., Junnarkar, S., Ravindranath, B., Southekal, S., Stoll, S., Smith, S. D., Lenz, W., Pratte, J. F., Purschke, M., Rescia, S., Krishnamoorthy, S., Vaska, P., Woody, C., & Schlyer, D. (2008). An MR compatible PET scanner based on RatCAP for small animal imaging at 9.4 T. In 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008 (pp. 3679-3682). Article 4774114 (IEEE Nuclear Science Symposium Conference Record). https://doi.org/10.1109/NSSMIC.2008.4774114

@inproceedings{4e86865a516f4cb594143647a0a248c8,

title = "An MR compatible PET scanner based on RatCAP for small animal imaging at 9.4 T",

abstract = "Combining PET and MRI technology in order to obtain simultaneous functional information with anatomical precision in vivo is of tremendous interest in the field of molecular imaging. PETIMRI imaging provides perfect anatomical and temporal coregistration of PET and MR images, along with clear delineation of tissue boundaries. An MR compatible PET scanner based on Rat Conscious Animal PET (RatCAP) is developed for simultaneous acquisition of PETIMRI images of the rat brain in a 9.4 T microMRI scanner. The PET tomograph is housed in a segmented G1O/copper case constructed with a copper coating thickness of 5 microns, to minimize the eddy currents and provide better RF shielding. Special RF coils were designed to fit inside the PET tomograph. A custom made GIO tube assembly was constructed for accurate positioning of the rat bed, RF coil and RatCAP. Simultaneous PETIMRI images of a rat striatum phantom were acquired in the 9.4 T microMRI with minimal interference between PET electronics and MRI. PET compatible RF quadrature coils are being constructed which are capable of providing rat brain images with improved SNR. The preliminary results show the feasibility of performing PET studies of rat brain and exploring the possibility of acquiring simultaneous PETIMRI whole body mouse images in the 9.4 T.",

author = "Maramraju, \{S. H.\} and S. Junnarkar and B. Ravindranath and S. Southekal and S. Stoll and Smith, \{S. D.\} and W. Lenz and Pratte, \{J. F.\} and M. Purschke and S. Rescia and S. Krishnamoorthy and P. Vaska and C. Woody and D. Schlyer",

year = "2008",

doi = "10.1109/NSSMIC.2008.4774114",

language = "English",

isbn = "9781424427154",

series = "IEEE Nuclear Science Symposium Conference Record",

pages = "3679--3682",

booktitle = "2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008",

note = "2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008 ; Conference date: 19-10-2008 Through 25-10-2008",

}

Maramraju, SH, Junnarkar, S, Ravindranath, B, Southekal, S, Stoll, S, Smith, SD, Lenz, W, Pratte, JF, Purschke, M, Rescia, S, Krishnamoorthy, S, Vaska, P, Woody, C & Schlyer, D 2008, An MR compatible PET scanner based on RatCAP for small animal imaging at 9.4 T. in 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008., 4774114, IEEE Nuclear Science Symposium Conference Record, pp. 3679-3682, 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008, Dresden, Germany, 10/19/08. https://doi.org/10.1109/NSSMIC.2008.4774114

An MR compatible PET scanner based on RatCAP for small animal imaging at 9.4 T. / Maramraju, S. H.; Junnarkar, S.; Ravindranath, B. et al.
2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008. 2008. p. 3679-3682 4774114 (IEEE Nuclear Science Symposium Conference Record).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Ravindranath, B.

AU - Southekal, S.

AU - Stoll, S.

AU - Smith, S. D.

AU - Lenz, W.

AU - Pratte, J. F.

AU - Purschke, M.

AU - Rescia, S.

AU - Krishnamoorthy, S.

AU - Vaska, P.

AU - Woody, C.

AU - Schlyer, D.

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N2 - Combining PET and MRI technology in order to obtain simultaneous functional information with anatomical precision in vivo is of tremendous interest in the field of molecular imaging. PETIMRI imaging provides perfect anatomical and temporal coregistration of PET and MR images, along with clear delineation of tissue boundaries. An MR compatible PET scanner based on Rat Conscious Animal PET (RatCAP) is developed for simultaneous acquisition of PETIMRI images of the rat brain in a 9.4 T microMRI scanner. The PET tomograph is housed in a segmented G1O/copper case constructed with a copper coating thickness of 5 microns, to minimize the eddy currents and provide better RF shielding. Special RF coils were designed to fit inside the PET tomograph. A custom made GIO tube assembly was constructed for accurate positioning of the rat bed, RF coil and RatCAP. Simultaneous PETIMRI images of a rat striatum phantom were acquired in the 9.4 T microMRI with minimal interference between PET electronics and MRI. PET compatible RF quadrature coils are being constructed which are capable of providing rat brain images with improved SNR. The preliminary results show the feasibility of performing PET studies of rat brain and exploring the possibility of acquiring simultaneous PETIMRI whole body mouse images in the 9.4 T.

AB - Combining PET and MRI technology in order to obtain simultaneous functional information with anatomical precision in vivo is of tremendous interest in the field of molecular imaging. PETIMRI imaging provides perfect anatomical and temporal coregistration of PET and MR images, along with clear delineation of tissue boundaries. An MR compatible PET scanner based on Rat Conscious Animal PET (RatCAP) is developed for simultaneous acquisition of PETIMRI images of the rat brain in a 9.4 T microMRI scanner. The PET tomograph is housed in a segmented G1O/copper case constructed with a copper coating thickness of 5 microns, to minimize the eddy currents and provide better RF shielding. Special RF coils were designed to fit inside the PET tomograph. A custom made GIO tube assembly was constructed for accurate positioning of the rat bed, RF coil and RatCAP. Simultaneous PETIMRI images of a rat striatum phantom were acquired in the 9.4 T microMRI with minimal interference between PET electronics and MRI. PET compatible RF quadrature coils are being constructed which are capable of providing rat brain images with improved SNR. The preliminary results show the feasibility of performing PET studies of rat brain and exploring the possibility of acquiring simultaneous PETIMRI whole body mouse images in the 9.4 T.

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U2 - 10.1109/NSSMIC.2008.4774114

DO - 10.1109/NSSMIC.2008.4774114

M3 - Conference contribution

AN - SCOPUS:67649232487

SN - 9781424427154

T3 - IEEE Nuclear Science Symposium Conference Record

SP - 3679

EP - 3682

BT - 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008

T2 - 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008

Y2 - 19 October 2008 through 25 October 2008

ER -

An MR compatible PET scanner based on RatCAP for small animal imaging at 9.4 T

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