Analytic review: Interleukin-6 in surgery, trauma, and critical care: Part I: Basic science

Randeep S. Jawa; Sergio Anillo; Kristin Huntoon; Heinz Baumann; Mahmoud Kulaylat

doi:10.1177/0885066610395678

Analytic review: Interleukin-6 in surgery, trauma, and critical care: Part I: Basic science

Randeep S. Jawa
, Sergio Anillo
, Kristin Huntoon
, Heinz Baumann
, Mahmoud Kulaylat

Surgery

SUNY Buffalo
Roswell Park Cancer Institute

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Abstract

A variety of cytokines play a role in the response to an inflammatory stimulus. The interleukin-6 (IL-6)-type cytokines are released in response to tissue injury or an inflammatory stimulus. They act locally and systemically to generate a variety of physiologic responses, principal among them is the acute phase response. The IL-6 type cytokines demonstrate pleiotropy and redundancy of actions. This is made possible by the distinctive characteristics of the IL-6 receptor complex, which contains an ubiquitous subunit that is shared by most IL-6-type cytokines, as well as a cytokine-specific subunit.

Original language	English
Pages (from-to)	3-12
Number of pages	10
Journal	Journal of Intensive Care Medicine
Volume	26
Issue number	1
DOIs	https://doi.org/10.1177/0885066610395678
State	Published - Jan 2011

Keywords

ARDS
critical care
cytokine
IL-6
interleukin
laparoscopy
sepsis
trauma

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10.1177/0885066610395678

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abstract = "A variety of cytokines play a role in the response to an inflammatory stimulus. The interleukin-6 (IL-6)-type cytokines are released in response to tissue injury or an inflammatory stimulus. They act locally and systemically to generate a variety of physiologic responses, principal among them is the acute phase response. The IL-6 type cytokines demonstrate pleiotropy and redundancy of actions. This is made possible by the distinctive characteristics of the IL-6 receptor complex, which contains an ubiquitous subunit that is shared by most IL-6-type cytokines, as well as a cytokine-specific subunit.",

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AU - Kulaylat, Mahmoud

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Analytic review: Interleukin-6 in surgery, trauma, and critical care: Part I: Basic science

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Keywords

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