TY - JOUR
T1 - APOE genotype and MRI markers of cerebrovascular disease
AU - Schilling, Sabrina
AU - DeStefano, Anita L.
AU - Sachdev, Perminder S.
AU - Choi, Seung Hoan
AU - Mather, Karen A.
AU - DeCarli, Charles D.
AU - Wen, Wei
AU - Høgh, Peter
AU - Raz, Naftali
AU - Au, Rhoda
AU - Beiser, Alexa
AU - Wolf, Philip A.
AU - Romero, José Rafael
AU - Zhu, Yi Cheng
AU - Lunetta, Kathryn L.
AU - Farrer, Lindsay
AU - Dufouil, Carole
AU - Kuller, Lewis H.
AU - Mazoyer, Bernard
AU - Seshadri, Sudha
AU - Tzourio, Christophe
AU - Debette, Stéphanie
PY - 2013/7/16
Y1 - 2013/7/16
N2 - Objective: We aimed to examine the association of APOE e genotype with MRI markers of cerebrovascular disease (CVD): white matter hyperintensities, brain infarcts, and cerebral microbleeds. Methods: We performed a systematic review and meta-analysis of 42 cross-sectional or longitudinal studies identified in PubMed from 1966 to June 2012 (n 5 29,965). This included unpublished data from 3 population-based studies: 3C-Dijon, Framingham Heart Study, and Sydney Memory and Ageing Study. When necessary, authors were contacted to provide effect estimates for the meta-analysis. Results: APOE e4 carrier status and APOE e44 genotype were associated with increasing white matter hyperintensity burden (sample size-weighted z score meta-analysis [meta]-p 5 0.0034 and 0.0030) and presence of cerebral microbleeds (meta odds ratio [OR] 5 1.24, 95% confidence interval [CI] [1.07, 1.43], p 5 0.004, and 1.87 [1.26, 2.78], p 5 0.002), especially lobar. APOE e2 carrier status was associated with increasing white matter hyperintensity load (z score meta-p 5 0.00053) and risk of brain infarct (meta OR 5 1.41[1.09, 1.81], p 5 0.008). Conclusions: APOEe4andAPOEe2 were associated with increasing burden inMRImarkers for both hemorrhagic and ischemic CVD. While the association of APOE e4 with an increased burden of CVD could be partly contributing to the relationship between APOE e4 and AD, APOE e2was associated with MRI markers of CVD in the opposite direction compared to AD.
AB - Objective: We aimed to examine the association of APOE e genotype with MRI markers of cerebrovascular disease (CVD): white matter hyperintensities, brain infarcts, and cerebral microbleeds. Methods: We performed a systematic review and meta-analysis of 42 cross-sectional or longitudinal studies identified in PubMed from 1966 to June 2012 (n 5 29,965). This included unpublished data from 3 population-based studies: 3C-Dijon, Framingham Heart Study, and Sydney Memory and Ageing Study. When necessary, authors were contacted to provide effect estimates for the meta-analysis. Results: APOE e4 carrier status and APOE e44 genotype were associated with increasing white matter hyperintensity burden (sample size-weighted z score meta-analysis [meta]-p 5 0.0034 and 0.0030) and presence of cerebral microbleeds (meta odds ratio [OR] 5 1.24, 95% confidence interval [CI] [1.07, 1.43], p 5 0.004, and 1.87 [1.26, 2.78], p 5 0.002), especially lobar. APOE e2 carrier status was associated with increasing white matter hyperintensity load (z score meta-p 5 0.00053) and risk of brain infarct (meta OR 5 1.41[1.09, 1.81], p 5 0.008). Conclusions: APOEe4andAPOEe2 were associated with increasing burden inMRImarkers for both hemorrhagic and ischemic CVD. While the association of APOE e4 with an increased burden of CVD could be partly contributing to the relationship between APOE e4 and AD, APOE e2was associated with MRI markers of CVD in the opposite direction compared to AD.
UR - https://www.scopus.com/pages/publications/84881297582
U2 - 10.1212/WNL.0b013e31829bfda4
DO - 10.1212/WNL.0b013e31829bfda4
M3 - Review article
C2 - 23858411
AN - SCOPUS:84881297582
SN - 0028-3878
VL - 81
SP - 292
EP - 300
JO - Neurology
JF - Neurology
IS - 3
ER -