Apolipoprotein A-IV reduces hepatic gluconeogenesis through nuclear receptor NR1D1

Background: The role of apoA-IV in hepatic gluconeogenesis is unknown. Results: ApoA-IV interacts with NR1D1and stimulates its expression and decreases hepatic Glc-6-Pase and PEPCK expression and glucose production. Conclusion: ApoA-IV inhibits hepatic gluconeogenesis by suppressing Glc-6-Pase and PEPCK expression through the NR1D1 pathway. Significance: This finding links lipid and carbohydrate metabolism and is crucial for understanding apoA-IV physiologic processes on glucose homeostasis.