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Application of I&Q detection system in scouting the curative effect of neck squamous cell carcinoma

  • Jun Zhang
  • , Tao Tu
  • , Ulas Sunar
  • , Xavier Intes
  • , Shoko Nioka
  • , Zhihong Zhang
  • , Alex Kilger
  • , Robert Lustig
  • , Laurie Loevner
  • , Britton Chance
  • University of Pennsylvania

Research output: Contribution to journalConference articlepeer-review

4 Scopus citations

Abstract

Near Infrared Spectroscopy (NIRS) has been widely used in cancer imaging spectroscopy because cancer tissue has more blood volume and less oxygen than normal tissue. The neck squamous cell carcinoma is ideal for our study because it's a surface mass can be easily feel through the skin. We use a simple homodyne phase modulation system, Inphase and Quadrature Phase (I&Q) Detection system, to study the curative effect of therapy in neck cancer patients. Clinical treatment includes mainly chemical and radiation therapy, both of which alter the blood volume and the oxygenation saturation in cancer tissue. The I&Q detection system is capable of the quantification measurement of those biological changes. In this paper, we will simply introduce the I&Q detection system's principle and constitution, and mainly explain the analysis of patients' data.

Original languageEnglish
Pages (from-to)575-580
Number of pages6
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume4955
DOIs
StatePublished - 2003
EventPROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Optical Tomography and Spectroscopy of Tissue V - San Jose, CA, United States
Duration: Jan 26 2003Jan 29 2003

Keywords

  • I&Q detection system
  • Neck squamous cell carcinoma
  • NIRS

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