TY - GEN
T1 - Applications of population balance equation modeling to pharmaceutical emulsions
AU - Raikar, Neha B.
AU - Bhatia, Surita R.
AU - Malone, Michael F.
AU - Henson, Michael A.
PY - 2009
Y1 - 2009
N2 - Emulsions are usually generated in highpressure homogenization chambers. The flow field is these units are typically highly turbulent and chaotic, and mechanisms for drop formation under these conditions are not well understood. In this paper, we have applied the PBE modeling approach to droplet break-up in a high pressure homogenizer using mechanistic functions for breakage rate. We have compared our modeling results to experimental data that we have obtained on a model oil-in-water emulsion. In principle, once these functions are known, the PBE approach can be used in a predictive manner to aid in the selection of process and product variables that will lead to the desired drop size distribution. This was verified for a number of test cases by changing product properties and homogenizing conditions. We observed that the population balance model did a reasonably good job of predicting the drop size distribution and therefore look promising. For cases where the model fails, we discuss strategies for improving predictions for these types of systems.
AB - Emulsions are usually generated in highpressure homogenization chambers. The flow field is these units are typically highly turbulent and chaotic, and mechanisms for drop formation under these conditions are not well understood. In this paper, we have applied the PBE modeling approach to droplet break-up in a high pressure homogenizer using mechanistic functions for breakage rate. We have compared our modeling results to experimental data that we have obtained on a model oil-in-water emulsion. In principle, once these functions are known, the PBE approach can be used in a predictive manner to aid in the selection of process and product variables that will lead to the desired drop size distribution. This was verified for a number of test cases by changing product properties and homogenizing conditions. We observed that the population balance model did a reasonably good job of predicting the drop size distribution and therefore look promising. For cases where the model fails, we discuss strategies for improving predictions for these types of systems.
UR - https://www.scopus.com/pages/publications/70349089336
U2 - 10.1109/NEBC.2009.4967810
DO - 10.1109/NEBC.2009.4967810
M3 - Conference contribution
AN - SCOPUS:70349089336
SN - 9781424443628
T3 - Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
BT - NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - IEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009
Y2 - 3 April 2009 through 5 April 2009
ER -