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Applications of "tender" energy (1-5 keV) X-ray absorption spectroscopy in life sciences

  • Marymount Manhattan College
  • Brookhaven National Laboratory

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The "tender" energy range of 1 to 5 keV, between the energy ranges of most "hard" (>5 keV) and "soft" (<1 keV) synchrotron X-ray facilities, offers some unique opportunities for synchrotron- based X-ray absorption fine structure spectroscopy in life sciences. In particular the K absorption edges of Na through Ca offer opportunities to study local structure, speciation, and chemistry of many important biological compounds, structures and processes. This is an area of largely untapped science, in part due to a scarcity of optimized facilities. Such measurements also entail unique experimental challenges. This brief review describes the technique, its experimental challenges, recent progress in development of microbeam measurement capabilities, and several highlights illustrating applications in life sciences.

Original languageEnglish
Pages (from-to)300-308
Number of pages9
JournalProtein and Peptide Letters
Volume23
Issue number3
DOIs
StatePublished - Mar 1 2016

Keywords

  • Calcium
  • EXAFS
  • Microbeam
  • Natural organochlorine
  • Sulfur
  • Tender-energy
  • X-ray absorption spectroscopy
  • X-ray spectromicroscopy
  • XANES

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