Artificial intelligence and the interplay between cancer and immunity

Rajarsi Gupta; Tahsin Kurc; Joel Haskin Saltz

doi:10.1016/B978-0-323-95359-7.00015-7

Artificial intelligence and the interplay between cancer and immunity

Biomedical Informatics

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The interplay between tumor and immunity is a fascinating aspect of cancer pathobiology with particular significance due to the emergence of immunotherapy. Advances in AI in computer vision have led to the emergence of computational pathology, where powerful Pathomics tools are being used to analyze large collections of digital whole slide images (WSIs) of cancer tissue samples. This chapter begins with an introduction to immune surveillance of cancer and immunotherapy, followed by descriptions of Pathomics applications to quantitatively evaluate and spatial map tumor-infiltrating lymphocytes (TILs) in the cancer microenvironment, and ends with a section on how spatial cancer biology can be studied by combining Pathomics with multiplex immunohistochemistry and immunofluorescence.

Original language	English
Title of host publication	Artificial Intelligence in Pathology
Subtitle of host publication	Principles and Applications, Second Edition
Publisher	Elsevier
Pages	309-341
Number of pages	33
ISBN (Electronic)	9780323953597
ISBN (Print)	9780323958325
DOIs	https://doi.org/10.1016/B978-0-323-95359-7.00015-7
State	Published - Jan 1 2024

Keywords

Cancer microenvironment
Computational pathology
Digital pathology
Pathomics
Tumor-infiltrating lymphocytes (TILs)

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10.1016/B978-0-323-95359-7.00015-7

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KW - Digital pathology

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BT - Artificial Intelligence in Pathology

PB - Elsevier

ER -

Artificial intelligence and the interplay between cancer and immunity

Abstract

Keywords

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