Association of a monoamine oxidase-A gene promoter polymorphism with ADHD and anxiety in boys with autism spectrum disorder

Jasmin Roohi; Carla J. DeVincent; Eli Hatchwell; Kenneth D. Gadow

doi:10.1007/s10803-008-0600-8

Association of a monoamine oxidase-A gene promoter polymorphism with ADHD and anxiety in boys with autism spectrum disorder

Jasmin Roohi
, Carla J. DeVincent
, Eli Hatchwell
, Kenneth D. Gadow

Psychiatry

Stony Brook University

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

The aim of the present study was to examine the association between a variable number tandem repeat (VNTR) functional polymorphism in the promoter region of the MAO-A gene and severity of ADHD and anxiety in boys with ASD. Parents and teachers completed a DSM-IV-referenced rating scale for 5- to 14-year-old boys with ASD (n = 43). Planned comparisons indicated that children with the 4- versus 3-repeat allele had significantly (p < 05) more severe parent-rated ADHD inattention and impulsivity, and more severe teacher-rated symptoms of generalized anxiety. Our results support a growing body of research indicating that concomitant behavioral disturbances in children with ASD warrant consideration as clinical phenotypes, but replication with independent samples is necessary to confirm this preliminary finding.

Original language	English
Pages (from-to)	67-74
Number of pages	8
Journal	Journal of Autism and Developmental Disorders
Volume	39
Issue number	1
DOIs	https://doi.org/10.1007/s10803-008-0600-8
State	Published - Jan 2009

Keywords

Asperger's syndrome
Attention-deficit/hyperactivity disorder
Autism
Autism spectrum disorder
Generalized anxiety disorder
Genetics
MAO-A
Monoamine oxidase
PDD-NOS

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10.1007/s10803-008-0600-8

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abstract = "The aim of the present study was to examine the association between a variable number tandem repeat (VNTR) functional polymorphism in the promoter region of the MAO-A gene and severity of ADHD and anxiety in boys with ASD. Parents and teachers completed a DSM-IV-referenced rating scale for 5- to 14-year-old boys with ASD (n = 43). Planned comparisons indicated that children with the 4- versus 3-repeat allele had significantly (p < 05) more severe parent-rated ADHD inattention and impulsivity, and more severe teacher-rated symptoms of generalized anxiety. Our results support a growing body of research indicating that concomitant behavioral disturbances in children with ASD warrant consideration as clinical phenotypes, but replication with independent samples is necessary to confirm this preliminary finding.",

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AU - Gadow, Kenneth D.

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AB - The aim of the present study was to examine the association between a variable number tandem repeat (VNTR) functional polymorphism in the promoter region of the MAO-A gene and severity of ADHD and anxiety in boys with ASD. Parents and teachers completed a DSM-IV-referenced rating scale for 5- to 14-year-old boys with ASD (n = 43). Planned comparisons indicated that children with the 4- versus 3-repeat allele had significantly (p < 05) more severe parent-rated ADHD inattention and impulsivity, and more severe teacher-rated symptoms of generalized anxiety. Our results support a growing body of research indicating that concomitant behavioral disturbances in children with ASD warrant consideration as clinical phenotypes, but replication with independent samples is necessary to confirm this preliminary finding.

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KW - Generalized anxiety disorder

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KW - MAO-A

KW - Monoamine oxidase

KW - PDD-NOS

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Association of a monoamine oxidase-A gene promoter polymorphism with ADHD and anxiety in boys with autism spectrum disorder

Abstract

Keywords

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