Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract

Daniele Campa; Mia Hashibe; David Zaridze; Neonila Szeszenia-Dabrowska; Ioan Nicolae Mates; Vladimir Janout; Ivana Holcatova; Eleonóra Fabiánová; Valérie Gaborieau; Rayjean J. Hung; Paolo Boffetta; Paul Brennan; Federico Canzian

doi:10.1007/s10552-007-0129-8

Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract

Daniele Campa
, Mia Hashibe
, David Zaridze
, Neonila Szeszenia-Dabrowska
, Ioan Nicolae Mates
, Vladimir Janout
, Ivana Holcatova
, Eleonóra Fabiánová
, Valérie Gaborieau
, Rayjean J. Hung
, Paolo Boffetta
, Paul Brennan
, Federico Canzian

Family , Population and Preventative Medicine

International Agency for Research on Cancer
University of Pisa
Cancer Research Center
Nofer Institute of Occupational Medicine
Carol Davila University of Medicine and Pharmacy
Palacký University Olomouc
Charles University
Specialized State Health Institute
German Cancer Research Center

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Objectives: The purpose of this study was to investigate the role of polymorphisms of genes involved in inflammation in the risk of cancers of the upper aerodigestive tract (UADT). Methods: We have evaluated the role of polymorphisms in key genes related to inflammation, namely IL1B (rs1143627), COX2/PTGS2 (rs5275), and IL8 (rs4073) in a large case-control study comprising 811 UADT cancer cases and 1,083 controls. Results: An association was observed for squamous cell carcinoma of the pharynx for a polymorphism in the promoter of the IL1B gene, with an OR of 2.39 (95% CI = 1.19-4.81) for the homozygotes for the minor allele A promoter polymorphism of IL8 was associated with decreased risk of laryngeal cancer, with an OR of 0.70 (95% CI = 0.50-0.98) for carriers of the minor allele. Conclusions: To our knowledge, this is the first report on the role of these polymorphisms with respect to UADT carcinogenesis. Our results suggest that inflammation-related polymorphisms play a role, albeit minor, in the risk of developing cancers of the upper aerodigestive tract.

Original language	English
Pages (from-to)	449-455
Number of pages	7
Journal	Cancer Causes and Control
Volume	18
Issue number	4
DOIs	https://doi.org/10.1007/s10552-007-0129-8
State	Published - May 2007

Keywords

Cyclooxygenase-2
Esophageal cancer
Interleukin-1
Interleukin-8
Larynx cancer
Oral cancer
Pharynx cancer
Upper aerodigestive tract cancers

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10.1007/s10552-007-0129-8

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Campa, D., Hashibe, M., Zaridze, D., Szeszenia-Dabrowska, N., Mates, I. N., Janout, V., Holcatova, I., Fabiánová, E., Gaborieau, V., Hung, R. J., Boffetta, P., Brennan, P., & Canzian, F. (2007). Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract. Cancer Causes and Control, 18(4), 449-455. https://doi.org/10.1007/s10552-007-0129-8

@article{936071e3e75143a6839a181ada5417eb,

title = "Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract",

abstract = "Objectives: The purpose of this study was to investigate the role of polymorphisms of genes involved in inflammation in the risk of cancers of the upper aerodigestive tract (UADT). Methods: We have evaluated the role of polymorphisms in key genes related to inflammation, namely IL1B (rs1143627), COX2/PTGS2 (rs5275), and IL8 (rs4073) in a large case-control study comprising 811 UADT cancer cases and 1,083 controls. Results: An association was observed for squamous cell carcinoma of the pharynx for a polymorphism in the promoter of the IL1B gene, with an OR of 2.39 (95\% CI = 1.19-4.81) for the homozygotes for the minor allele A promoter polymorphism of IL8 was associated with decreased risk of laryngeal cancer, with an OR of 0.70 (95\% CI = 0.50-0.98) for carriers of the minor allele. Conclusions: To our knowledge, this is the first report on the role of these polymorphisms with respect to UADT carcinogenesis. Our results suggest that inflammation-related polymorphisms play a role, albeit minor, in the risk of developing cancers of the upper aerodigestive tract.",

keywords = "Cyclooxygenase-2, Esophageal cancer, Interleukin-1, Interleukin-8, Larynx cancer, Oral cancer, Pharynx cancer, Upper aerodigestive tract cancers",

author = "Daniele Campa and Mia Hashibe and David Zaridze and Neonila Szeszenia-Dabrowska and Mates, \{Ioan Nicolae\} and Vladimir Janout and Ivana Holcatova and Eleon{\'o}ra Fabi{\'a}nov{\'a} and Val{\'e}rie Gaborieau and Hung, \{Rayjean J.\} and Paolo Boffetta and Paul Brennan and Federico Canzian",

year = "2007",

month = may,

doi = "10.1007/s10552-007-0129-8",

language = "English",

volume = "18",

pages = "449--455",

journal = "Cancer Causes and Control",

issn = "0957-5243",

number = "4",

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Campa, D, Hashibe, M, Zaridze, D, Szeszenia-Dabrowska, N, Mates, IN, Janout, V, Holcatova, I, Fabiánová, E, Gaborieau, V, Hung, RJ, Boffetta, P, Brennan, P & Canzian, F 2007, 'Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract', Cancer Causes and Control, vol. 18, no. 4, pp. 449-455. https://doi.org/10.1007/s10552-007-0129-8

TY - JOUR

T1 - Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract

AU - Campa, Daniele

AU - Hashibe, Mia

AU - Zaridze, David

AU - Szeszenia-Dabrowska, Neonila

AU - Mates, Ioan Nicolae

AU - Janout, Vladimir

AU - Holcatova, Ivana

AU - Fabiánová, Eleonóra

AU - Gaborieau, Valérie

AU - Hung, Rayjean J.

AU - Boffetta, Paolo

AU - Brennan, Paul

AU - Canzian, Federico

PY - 2007/5

Y1 - 2007/5

N2 - Objectives: The purpose of this study was to investigate the role of polymorphisms of genes involved in inflammation in the risk of cancers of the upper aerodigestive tract (UADT). Methods: We have evaluated the role of polymorphisms in key genes related to inflammation, namely IL1B (rs1143627), COX2/PTGS2 (rs5275), and IL8 (rs4073) in a large case-control study comprising 811 UADT cancer cases and 1,083 controls. Results: An association was observed for squamous cell carcinoma of the pharynx for a polymorphism in the promoter of the IL1B gene, with an OR of 2.39 (95% CI = 1.19-4.81) for the homozygotes for the minor allele A promoter polymorphism of IL8 was associated with decreased risk of laryngeal cancer, with an OR of 0.70 (95% CI = 0.50-0.98) for carriers of the minor allele. Conclusions: To our knowledge, this is the first report on the role of these polymorphisms with respect to UADT carcinogenesis. Our results suggest that inflammation-related polymorphisms play a role, albeit minor, in the risk of developing cancers of the upper aerodigestive tract.

AB - Objectives: The purpose of this study was to investigate the role of polymorphisms of genes involved in inflammation in the risk of cancers of the upper aerodigestive tract (UADT). Methods: We have evaluated the role of polymorphisms in key genes related to inflammation, namely IL1B (rs1143627), COX2/PTGS2 (rs5275), and IL8 (rs4073) in a large case-control study comprising 811 UADT cancer cases and 1,083 controls. Results: An association was observed for squamous cell carcinoma of the pharynx for a polymorphism in the promoter of the IL1B gene, with an OR of 2.39 (95% CI = 1.19-4.81) for the homozygotes for the minor allele A promoter polymorphism of IL8 was associated with decreased risk of laryngeal cancer, with an OR of 0.70 (95% CI = 0.50-0.98) for carriers of the minor allele. Conclusions: To our knowledge, this is the first report on the role of these polymorphisms with respect to UADT carcinogenesis. Our results suggest that inflammation-related polymorphisms play a role, albeit minor, in the risk of developing cancers of the upper aerodigestive tract.

KW - Cyclooxygenase-2

KW - Esophageal cancer

KW - Interleukin-1

KW - Interleukin-8

KW - Larynx cancer

KW - Oral cancer

KW - Pharynx cancer

KW - Upper aerodigestive tract cancers

UR - https://www.scopus.com/pages/publications/33947223773

U2 - 10.1007/s10552-007-0129-8

DO - 10.1007/s10552-007-0129-8

M3 - Article

C2 - 17356794

AN - SCOPUS:33947223773

SN - 0957-5243

VL - 18

SP - 449

EP - 455

JO - Cancer Causes and Control

JF - Cancer Causes and Control

IS - 4

ER -

Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract

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Keywords

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