Association of metabolic gene polymorphisms with tobacco consumption in healthy controls

Kim M. Smits; Simone Benhamou; Seymour Garte; Matty P. Weijenberg; Yannis Alamanos; Christine Ambrosone; Herman Autrup; Judith L. Autrup; Helena Baranova; Lisa Bathum; Paolo Boffetta; C. Bouchardy; Jurgen Brockmoller; Dorota Butkiewicz; Ingolf Cascorbi; Margie L. Clapper; Christiane Coutelle; Ann K. Daly; Giacomo Muzi; Vita Dolzan; Tatyana G. Duzhak; Katrin Farker; Klaus Golka; Aage Haugen; David W. Hein; Allan Hildesheim; Ari Hirvonen; Ling L. Hsieh; Magnus Ingelman-Sundberg; Ivan Kalina; Daehee Kang; Takahiko Katoh; Masahiro Kihara; Masako Ono-Kihara; Heon Kim; Chikako Kiyohara; Pierre Kremers; Philip Lazarus; Loic Le Marchand; Maria C. Lechner; Stephanie London; Johannes J. Manni; Christine M. Maugard; Gareth J. Morgan; Shunji Morita; Valle Nazar-Stewart; Vessela Nedelcheva Kristensen; Yoshio Oda; Fritz F. Parl; Wilbert H.M. Peters; Agneta Rannug; Timothy Rebbeck; Luis F.Ribeiro Pinto; Angela Risch; Marjorie Romkes; Jan Šalagovic; Bernadette Schoket; Janeric Seidegard; Peter G. Shields; Edith Sim; Daniel Sinnett; Richard C. Strange; Isabelle Stucker; Haruhiko Sugimura; Jordi To-Figueras; Paolo Vineis; Minii C. Yu; Wei Zheng; Paola Pedotti; Emanuela Taioli

doi:10.1002/ijc.20114

Association of metabolic gene polymorphisms with tobacco consumption in healthy controls

Kim M. Smits
, Simone Benhamou
, Seymour Garte
, Matty P. Weijenberg
, Yannis Alamanos
, Christine Ambrosone
, Herman Autrup
, Judith L. Autrup
, Helena Baranova
, Lisa Bathum
, Paolo Boffetta
, C. Bouchardy
, Jurgen Brockmoller
, Dorota Butkiewicz
, Ingolf Cascorbi
, Margie L. Clapper
, Christiane Coutelle
, Ann K. Daly
, Giacomo Muzi
, Vita Dolzan

Tatyana G. Duzhak, Katrin Farker, Klaus Golka, Aage Haugen, David W. Hein, Allan Hildesheim, Ari Hirvonen, Ling L. Hsieh, Magnus Ingelman-Sundberg, Ivan Kalina, Daehee Kang, Takahiko Katoh, Masahiro Kihara, Masako Ono-Kihara, Heon Kim, Chikako Kiyohara, Pierre Kremers, Philip Lazarus, Loic Le Marchand, Maria C. Lechner, Stephanie London, Johannes J. Manni, Christine M. Maugard, Gareth J. Morgan, Shunji Morita, Valle Nazar-Stewart, Vessela Nedelcheva Kristensen, Yoshio Oda, Fritz F. Parl, Wilbert H.M. Peters, Agneta Rannug, Timothy Rebbeck, Luis F.Ribeiro Pinto, Angela Risch, Marjorie Romkes, Jan Šalagovic, Bernadette Schoket, Janeric Seidegard, Peter G. Shields, Edith Sim, Daniel Sinnett, Richard C. Strange, Isabelle Stucker, Haruhiko Sugimura, Jordi To-Figueras, Paolo Vineis, Minii C. Yu, Wei Zheng, Paola Pedotti, Emanuela Taioli

Family , Population and Preventative Medicine

Maastricht University
Institut national de la santé et de la recherche médicale
University of Geneva
Genetics Research Institute
University of Ioannina
Roswell Park Cancer Institute
Aarhus University
Université Clermont Auvergne
University of Göttingen
Maria Sklodowska-Curie Institute of Oncology
University of Greifswald
Fox Chase Cancer Center
Université de Bordeaux
Newcastle University
Instituto Medicina del Lavoro
University of Ljubljana
University of Dortmund (IfADo)
Friedrich Schiller University Jena
National Institute of Occupational Health
University of Louisville
National Institutes of Health
Finnish Institute of Occupational Health
Chang Gung University
Karolinska Institutet
Pavol Jozef Šafárik University
Seoul National University
University of Miyazaki
Kyoto University
Chungbuk National University
Kyushu University
University of Liege
Moffitt Cancer Center
University of Hawai'i at Mānoa
University of Lisbon
Centre Georges-François Leclerc
University of Leeds
Yao Municipal Hospital
Oregon Health and Science University
University of Oslo
Kanazawa University
Vanderbilt University
Radboud University Nijmegen
University of Pennsylvania
Department of Bioquimica
German Cancer Research Center
University of Pittsburgh
Hungarian National Institute of Environmental Health
Lund University
Georgetown University
University of Oxford
Centre Hospitalier Universitaire Sainte-Justine
Keele University
Hamamatsu University School of Medicine
Hospital Clínic de Barcelona
University of Turin
National Taiwan University
IRCCS Fondazione Ca'Granda – Ospedale Maggiore Policlinico - Milano

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Polymorphisms in genes that encode for metabolic enzymes have been associated with variations in enzyme activity between individuals. Such variations could be associated with differences in individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sample of healthy individuals. The database of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens was used. All the individuals who were controls from the case-control studies included in the data set with information on smoking habits and on genetic polymorphisms were selected (n = 20,938). Sufficient information was available on the following genes that are involved in the metabolism of tobacco smoke constituents: CYP1A1, GSTM1, GSTT1, NAT2 and GSTP1. None of the tested genes was clearly associated with smoking behavior. Information on smoking dose, available for a subset of subjects, showed no effect of metabolic gene polymorphisms on the amount of smoking. No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected.

Original language	English
Pages (from-to)	266-270
Number of pages	5
Journal	International Journal of Cancer
Volume	110
Issue number	2
DOIs	https://doi.org/10.1002/ijc.20114
State	Published - Jun 10 2004

Keywords

Molecular epidemiology
Pooled analysis
Smoking

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10.1002/ijc.20114

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Smits, K. M., Benhamou, S., Garte, S., Weijenberg, M. P., Alamanos, Y., Ambrosone, C., Autrup, H., Autrup, J. L., Baranova, H., Bathum, L., Boffetta, P., Bouchardy, C., Brockmoller, J., Butkiewicz, D., Cascorbi, I., Clapper, M. L., Coutelle, C., Daly, A. K., Muzi, G., ... Taioli, E. (2004). Association of metabolic gene polymorphisms with tobacco consumption in healthy controls. International Journal of Cancer, 110(2), 266-270. https://doi.org/10.1002/ijc.20114

@article{84c84fa5b78a42dcb517d513c6ad5fd5,

title = "Association of metabolic gene polymorphisms with tobacco consumption in healthy controls",

abstract = "Polymorphisms in genes that encode for metabolic enzymes have been associated with variations in enzyme activity between individuals. Such variations could be associated with differences in individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sample of healthy individuals. The database of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens was used. All the individuals who were controls from the case-control studies included in the data set with information on smoking habits and on genetic polymorphisms were selected (n = 20,938). Sufficient information was available on the following genes that are involved in the metabolism of tobacco smoke constituents: CYP1A1, GSTM1, GSTT1, NAT2 and GSTP1. None of the tested genes was clearly associated with smoking behavior. Information on smoking dose, available for a subset of subjects, showed no effect of metabolic gene polymorphisms on the amount of smoking. No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected.",

keywords = "Molecular epidemiology, Pooled analysis, Smoking",

author = "Smits, \{Kim M.\} and Simone Benhamou and Seymour Garte and Weijenberg, \{Matty P.\} and Yannis Alamanos and Christine Ambrosone and Herman Autrup and Autrup, \{Judith L.\} and Helena Baranova and Lisa Bathum and Paolo Boffetta and C. Bouchardy and Jurgen Brockmoller and Dorota Butkiewicz and Ingolf Cascorbi and Clapper, \{Margie L.\} and Christiane Coutelle and Daly, \{Ann K.\} and Giacomo Muzi and Vita Dolzan and Duzhak, \{Tatyana G.\} and Katrin Farker and Klaus Golka and Aage Haugen and Hein, \{David W.\} and Allan Hildesheim and Ari Hirvonen and Hsieh, \{Ling L.\} and Magnus Ingelman-Sundberg and Ivan Kalina and Daehee Kang and Takahiko Katoh and Masahiro Kihara and Masako Ono-Kihara and Heon Kim and Chikako Kiyohara and Pierre Kremers and Philip Lazarus and \{Le Marchand\}, Loic and Lechner, \{Maria C.\} and Stephanie London and Manni, \{Johannes J.\} and Maugard, \{Christine M.\} and Morgan, \{Gareth J.\} and Shunji Morita and Valle Nazar-Stewart and Kristensen, \{Vessela Nedelcheva\} and Yoshio Oda and Parl, \{Fritz F.\} and Peters, \{Wilbert H.M.\} and Agneta Rannug and Timothy Rebbeck and Pinto, \{Luis F.Ribeiro\} and Angela Risch and Marjorie Romkes and Jan {\v S}alagovic and Bernadette Schoket and Janeric Seidegard and Shields, \{Peter G.\} and Edith Sim and Daniel Sinnett and Strange, \{Richard C.\} and Isabelle Stucker and Haruhiko Sugimura and Jordi To-Figueras and Paolo Vineis and Yu, \{Minii C.\} and Wei Zheng and Paola Pedotti and Emanuela Taioli",

year = "2004",

month = jun,

day = "10",

doi = "10.1002/ijc.20114",

language = "English",

volume = "110",

pages = "266--270",

journal = "International Journal of Cancer",

issn = "0020-7136",

number = "2",

}

Smits, KM, Benhamou, S, Garte, S, Weijenberg, MP, Alamanos, Y, Ambrosone, C, Autrup, H, Autrup, JL, Baranova, H, Bathum, L, Boffetta, P, Bouchardy, C, Brockmoller, J, Butkiewicz, D, Cascorbi, I, Clapper, ML, Coutelle, C, Daly, AK, Muzi, G, Dolzan, V, Duzhak, TG, Farker, K, Golka, K, Haugen, A, Hein, DW, Hildesheim, A, Hirvonen, A, Hsieh, LL, Ingelman-Sundberg, M, Kalina, I, Kang, D, Katoh, T, Kihara, M, Ono-Kihara, M, Kim, H, Kiyohara, C, Kremers, P, Lazarus, P, Le Marchand, L, Lechner, MC, London, S, Manni, JJ, Maugard, CM, Morgan, GJ, Morita, S, Nazar-Stewart, V, Kristensen, VN, Oda, Y, Parl, FF, Peters, WHM, Rannug, A, Rebbeck, T, Pinto, LFR, Risch, A, Romkes, M, Šalagovic, J, Schoket, B, Seidegard, J, Shields, PG, Sim, E, Sinnett, D, Strange, RC, Stucker, I, Sugimura, H, To-Figueras, J, Vineis, P, Yu, MC, Zheng, W, Pedotti, P & Taioli, E 2004, 'Association of metabolic gene polymorphisms with tobacco consumption in healthy controls', International Journal of Cancer, vol. 110, no. 2, pp. 266-270. https://doi.org/10.1002/ijc.20114

TY - JOUR

T1 - Association of metabolic gene polymorphisms with tobacco consumption in healthy controls

AU - Smits, Kim M.

AU - Benhamou, Simone

AU - Garte, Seymour

AU - Weijenberg, Matty P.

AU - Alamanos, Yannis

AU - Ambrosone, Christine

AU - Autrup, Herman

AU - Autrup, Judith L.

AU - Baranova, Helena

AU - Bathum, Lisa

AU - Boffetta, Paolo

AU - Bouchardy, C.

AU - Brockmoller, Jurgen

AU - Butkiewicz, Dorota

AU - Cascorbi, Ingolf

AU - Clapper, Margie L.

AU - Coutelle, Christiane

AU - Daly, Ann K.

AU - Muzi, Giacomo

AU - Dolzan, Vita

AU - Duzhak, Tatyana G.

AU - Farker, Katrin

AU - Golka, Klaus

AU - Haugen, Aage

AU - Hein, David W.

AU - Hildesheim, Allan

AU - Hirvonen, Ari

AU - Hsieh, Ling L.

AU - Ingelman-Sundberg, Magnus

AU - Kalina, Ivan

AU - Kang, Daehee

AU - Katoh, Takahiko

AU - Kihara, Masahiro

AU - Ono-Kihara, Masako

AU - Kim, Heon

AU - Kiyohara, Chikako

AU - Kremers, Pierre

AU - Lazarus, Philip

AU - Le Marchand, Loic

AU - Lechner, Maria C.

AU - London, Stephanie

AU - Manni, Johannes J.

AU - Maugard, Christine M.

AU - Morgan, Gareth J.

AU - Morita, Shunji

AU - Nazar-Stewart, Valle

AU - Kristensen, Vessela Nedelcheva

AU - Oda, Yoshio

AU - Parl, Fritz F.

AU - Peters, Wilbert H.M.

AU - Rannug, Agneta

AU - Rebbeck, Timothy

AU - Pinto, Luis F.Ribeiro

AU - Risch, Angela

AU - Romkes, Marjorie

AU - Šalagovic, Jan

AU - Schoket, Bernadette

AU - Seidegard, Janeric

AU - Shields, Peter G.

AU - Sim, Edith

AU - Sinnett, Daniel

AU - Strange, Richard C.

AU - Stucker, Isabelle

AU - Sugimura, Haruhiko

AU - To-Figueras, Jordi

AU - Vineis, Paolo

AU - Yu, Minii C.

AU - Zheng, Wei

AU - Pedotti, Paola

AU - Taioli, Emanuela

PY - 2004/6/10

Y1 - 2004/6/10

N2 - Polymorphisms in genes that encode for metabolic enzymes have been associated with variations in enzyme activity between individuals. Such variations could be associated with differences in individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sample of healthy individuals. The database of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens was used. All the individuals who were controls from the case-control studies included in the data set with information on smoking habits and on genetic polymorphisms were selected (n = 20,938). Sufficient information was available on the following genes that are involved in the metabolism of tobacco smoke constituents: CYP1A1, GSTM1, GSTT1, NAT2 and GSTP1. None of the tested genes was clearly associated with smoking behavior. Information on smoking dose, available for a subset of subjects, showed no effect of metabolic gene polymorphisms on the amount of smoking. No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected.

AB - Polymorphisms in genes that encode for metabolic enzymes have been associated with variations in enzyme activity between individuals. Such variations could be associated with differences in individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sample of healthy individuals. The database of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens was used. All the individuals who were controls from the case-control studies included in the data set with information on smoking habits and on genetic polymorphisms were selected (n = 20,938). Sufficient information was available on the following genes that are involved in the metabolism of tobacco smoke constituents: CYP1A1, GSTM1, GSTT1, NAT2 and GSTP1. None of the tested genes was clearly associated with smoking behavior. Information on smoking dose, available for a subset of subjects, showed no effect of metabolic gene polymorphisms on the amount of smoking. No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected.

KW - Molecular epidemiology

KW - Pooled analysis

KW - Smoking

UR - https://www.scopus.com/pages/publications/2342612759

U2 - 10.1002/ijc.20114

DO - 10.1002/ijc.20114

M3 - Article

C2 - 15069692

AN - SCOPUS:2342612759

SN - 0020-7136

VL - 110

SP - 266

EP - 270

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 2

ER -

Association of metabolic gene polymorphisms with tobacco consumption in healthy controls

Abstract

Keywords

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