Asthma and lung cancer risk: A systematic investigation by the international lung cancer consortium

Albert Rosenberger; Heike Bickeböller; Valerie McCormack; Darren R. Brenner; Eric J. Duell; Anne Tjønneland; Soren Friis; Joshua E. Muscat; Ping Yang; H. Erich Wichmann; Joachim Heinrich; Neonila Szeszenia-Dabrowska; Jolanta Lissowska; David Zaridze; Peter Rudnai; Eleonora Fabianova; Vladimir Janout; Vladimir Bencko; Paul Brennan; Dana Mates; Ann G. Schwartz; Michele L. Cote; Zuo Feng Zhang; Hal Morgenstern; Sam S. Oh; John K. Field; Olaide Raji; John R. McLaughlin; John Wiencke; Loic LeMarchand; Monica Neri; Stefano Bonassi; Angeline S. Andrew; Qing Lan; Wei Hu; Irene Orlow; Bernard J. Park; Paolo Boffetta; Rayjean J. Hung

doi:10.1093/carcin/bgr307

Asthma and lung cancer risk: A systematic investigation by the international lung cancer consortium

Albert Rosenberger
, Heike Bickeböller
, Valerie McCormack
, Darren R. Brenner
, Eric J. Duell
, Anne Tjønneland
, Soren Friis
, Joshua E. Muscat
, Ping Yang
, H. Erich Wichmann
, Joachim Heinrich
, Neonila Szeszenia-Dabrowska
, Jolanta Lissowska
, David Zaridze
, Peter Rudnai
, Eleonora Fabianova
, Vladimir Janout
, Vladimir Bencko
, Paul Brennan
, Dana Mates

Ann G. Schwartz, Michele L. Cote, Zuo Feng Zhang, Hal Morgenstern, Sam S. Oh, John K. Field, Olaide Raji, John R. McLaughlin, John Wiencke, Loic LeMarchand, Monica Neri, Stefano Bonassi, Angeline S. Andrew, Qing Lan, Wei Hu, Irene Orlow, Bernard J. Park, Paolo Boffetta, Rayjean J. Hung

University of Göttingen
International Agency for Research on Cancer
University of Toronto
Institute Catala Oncologia
Danish Cancer Society
Pennsylvania State University
Mayo Clinic Rochester, MN
Helmholtz Zentrum München - German Research Center for Environmental Health
Ludwig Maximilian University of Munich
Nofer Institute of Occupational Medicine
Maria Sklodowska-Curie Institute of Oncology
Blokhin Cancer Research Center
Fodor József National Center for Public Health
Specialized State Health Institute
Palacký University Olomouc
Charles University
Carol Davila University of Medicine and Pharmacy
Wayne State University
University of California at Los Angeles
University of Michigan, Ann Arbor
University of California at San Francisco
University of Liverpool
University of Hawaii
IRCCS San Raffaele Pisana - Roma
Dartmouth College
National Institutes of Health
Memorial Sloan-Kettering Cancer Center

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

Asthma has been hypothesized to be associated with lung cancer (LC) risk. We conducted a pooled analysis of 16 studies in the International Lung Cancer Consortium (ILCCO) to quantitatively assess this association and compared the results with 36 previously published studies. In total, information from 585 444 individuals was used. Study-specific measures were combined using random effects models. A meta-regression and subgroup meta-analyses were performed to identify sources of heterogeneity. The overall LC relative risk (RR) associated with asthma was 1.28 [95% confidence intervals (CIs) = 1.16-1.41] but with large heterogeneity (I2 = 73%, P < 0.001) between studies. Among ILCCO studies, an increased risk was found for squamous cell (RR = 1.69, 9=%, CI = 1.26-2.26) and for small-cell carcinoma (RR = 1.71, 9=% CI = 0.99-2.95) but was weaker for adenocarcinoma (RR = 1.09, 95% CI = 0.88-1.36). The increased LC risk was strongest in the 2 years after asthma diagnosis (RR = 2.13, 95% CI = 1.09-4.17) but subjects diagnosed with asthma over 10 years prior had no or little increased LC risk (RR = 1.10, 95% CI = 0.94-1.30). Because the increased incidence of LC was chiefly observed in small cell and squamous cell lung carcinomas, primarily within 2 years of asthma diagnosis and because the association was weak among never smokers, we conclude that the association may not reflect a causal effect of asthma on the risk of LC.

Original language	English
Pages (from-to)	587-597
Number of pages	11
Journal	Carcinogenesis
Volume	33
Issue number	3
DOIs	https://doi.org/10.1093/carcin/bgr307
State	Published - Mar 2012

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Rosenberger, A., Bickeböller, H., McCormack, V., Brenner, D. R., Duell, E. J., Tjønneland, A., Friis, S., Muscat, J. E., Yang, P., Wichmann, H. E., Heinrich, J., Szeszenia-Dabrowska, N., Lissowska, J., Zaridze, D., Rudnai, P., Fabianova, E., Janout, V., Bencko, V., Brennan, P., ... Hung, R. J. (2012). Asthma and lung cancer risk: A systematic investigation by the international lung cancer consortium. Carcinogenesis, 33(3), 587-597. https://doi.org/10.1093/carcin/bgr307

@article{5e594ada60014946877f6e46d2cedba2,

title = "Asthma and lung cancer risk: A systematic investigation by the international lung cancer consortium",

abstract = "Asthma has been hypothesized to be associated with lung cancer (LC) risk. We conducted a pooled analysis of 16 studies in the International Lung Cancer Consortium (ILCCO) to quantitatively assess this association and compared the results with 36 previously published studies. In total, information from 585 444 individuals was used. Study-specific measures were combined using random effects models. A meta-regression and subgroup meta-analyses were performed to identify sources of heterogeneity. The overall LC relative risk (RR) associated with asthma was 1.28 [95\% confidence intervals (CIs) = 1.16-1.41] but with large heterogeneity (I2 = 73\%, P < 0.001) between studies. Among ILCCO studies, an increased risk was found for squamous cell (RR = 1.69, 9=\%, CI = 1.26-2.26) and for small-cell carcinoma (RR = 1.71, 9=\% CI = 0.99-2.95) but was weaker for adenocarcinoma (RR = 1.09, 95\% CI = 0.88-1.36). The increased LC risk was strongest in the 2 years after asthma diagnosis (RR = 2.13, 95\% CI = 1.09-4.17) but subjects diagnosed with asthma over 10 years prior had no or little increased LC risk (RR = 1.10, 95\% CI = 0.94-1.30). Because the increased incidence of LC was chiefly observed in small cell and squamous cell lung carcinomas, primarily within 2 years of asthma diagnosis and because the association was weak among never smokers, we conclude that the association may not reflect a causal effect of asthma on the risk of LC.",

author = "Albert Rosenberger and Heike Bickeb{\"o}ller and Valerie McCormack and Brenner, \{Darren R.\} and Duell, \{Eric J.\} and Anne Tj{\o}nneland and Soren Friis and Muscat, \{Joshua E.\} and Ping Yang and Wichmann, \{H. Erich\} and Joachim Heinrich and Neonila Szeszenia-Dabrowska and Jolanta Lissowska and David Zaridze and Peter Rudnai and Eleonora Fabianova and Vladimir Janout and Vladimir Bencko and Paul Brennan and Dana Mates and Schwartz, \{Ann G.\} and Cote, \{Michele L.\} and Zhang, \{Zuo Feng\} and Hal Morgenstern and Oh, \{Sam S.\} and Field, \{John K.\} and Olaide Raji and McLaughlin, \{John R.\} and John Wiencke and Loic LeMarchand and Monica Neri and Stefano Bonassi and Andrew, \{Angeline S.\} and Qing Lan and Wei Hu and Irene Orlow and Park, \{Bernard J.\} and Paolo Boffetta and Hung, \{Rayjean J.\}",

year = "2012",

month = mar,

doi = "10.1093/carcin/bgr307",

language = "English",

volume = "33",

pages = "587--597",

journal = "Carcinogenesis",

issn = "0143-3334",

number = "3",

}

Rosenberger, A, Bickeböller, H, McCormack, V, Brenner, DR, Duell, EJ, Tjønneland, A, Friis, S, Muscat, JE, Yang, P, Wichmann, HE, Heinrich, J, Szeszenia-Dabrowska, N, Lissowska, J, Zaridze, D, Rudnai, P, Fabianova, E, Janout, V, Bencko, V, Brennan, P, Mates, D, Schwartz, AG, Cote, ML, Zhang, ZF, Morgenstern, H, Oh, SS, Field, JK, Raji, O, McLaughlin, JR, Wiencke, J, LeMarchand, L, Neri, M, Bonassi, S, Andrew, AS, Lan, Q, Hu, W, Orlow, I, Park, BJ, Boffetta, P & Hung, RJ 2012, 'Asthma and lung cancer risk: A systematic investigation by the international lung cancer consortium', Carcinogenesis, vol. 33, no. 3, pp. 587-597. https://doi.org/10.1093/carcin/bgr307

TY - JOUR

T1 - Asthma and lung cancer risk

T2 - A systematic investigation by the international lung cancer consortium

AU - Rosenberger, Albert

AU - Bickeböller, Heike

AU - McCormack, Valerie

AU - Brenner, Darren R.

AU - Duell, Eric J.

AU - Tjønneland, Anne

AU - Friis, Soren

AU - Muscat, Joshua E.

AU - Yang, Ping

AU - Wichmann, H. Erich

AU - Heinrich, Joachim

AU - Szeszenia-Dabrowska, Neonila

AU - Lissowska, Jolanta

AU - Zaridze, David

AU - Rudnai, Peter

AU - Fabianova, Eleonora

AU - Janout, Vladimir

AU - Bencko, Vladimir

AU - Brennan, Paul

AU - Mates, Dana

AU - Schwartz, Ann G.

AU - Cote, Michele L.

AU - Zhang, Zuo Feng

AU - Morgenstern, Hal

AU - Oh, Sam S.

AU - Field, John K.

AU - Raji, Olaide

AU - McLaughlin, John R.

AU - Wiencke, John

AU - LeMarchand, Loic

AU - Neri, Monica

AU - Bonassi, Stefano

AU - Andrew, Angeline S.

AU - Lan, Qing

AU - Hu, Wei

AU - Orlow, Irene

AU - Park, Bernard J.

AU - Boffetta, Paolo

AU - Hung, Rayjean J.

PY - 2012/3

Y1 - 2012/3

N2 - Asthma has been hypothesized to be associated with lung cancer (LC) risk. We conducted a pooled analysis of 16 studies in the International Lung Cancer Consortium (ILCCO) to quantitatively assess this association and compared the results with 36 previously published studies. In total, information from 585 444 individuals was used. Study-specific measures were combined using random effects models. A meta-regression and subgroup meta-analyses were performed to identify sources of heterogeneity. The overall LC relative risk (RR) associated with asthma was 1.28 [95% confidence intervals (CIs) = 1.16-1.41] but with large heterogeneity (I2 = 73%, P < 0.001) between studies. Among ILCCO studies, an increased risk was found for squamous cell (RR = 1.69, 9=%, CI = 1.26-2.26) and for small-cell carcinoma (RR = 1.71, 9=% CI = 0.99-2.95) but was weaker for adenocarcinoma (RR = 1.09, 95% CI = 0.88-1.36). The increased LC risk was strongest in the 2 years after asthma diagnosis (RR = 2.13, 95% CI = 1.09-4.17) but subjects diagnosed with asthma over 10 years prior had no or little increased LC risk (RR = 1.10, 95% CI = 0.94-1.30). Because the increased incidence of LC was chiefly observed in small cell and squamous cell lung carcinomas, primarily within 2 years of asthma diagnosis and because the association was weak among never smokers, we conclude that the association may not reflect a causal effect of asthma on the risk of LC.

AB - Asthma has been hypothesized to be associated with lung cancer (LC) risk. We conducted a pooled analysis of 16 studies in the International Lung Cancer Consortium (ILCCO) to quantitatively assess this association and compared the results with 36 previously published studies. In total, information from 585 444 individuals was used. Study-specific measures were combined using random effects models. A meta-regression and subgroup meta-analyses were performed to identify sources of heterogeneity. The overall LC relative risk (RR) associated with asthma was 1.28 [95% confidence intervals (CIs) = 1.16-1.41] but with large heterogeneity (I2 = 73%, P < 0.001) between studies. Among ILCCO studies, an increased risk was found for squamous cell (RR = 1.69, 9=%, CI = 1.26-2.26) and for small-cell carcinoma (RR = 1.71, 9=% CI = 0.99-2.95) but was weaker for adenocarcinoma (RR = 1.09, 95% CI = 0.88-1.36). The increased LC risk was strongest in the 2 years after asthma diagnosis (RR = 2.13, 95% CI = 1.09-4.17) but subjects diagnosed with asthma over 10 years prior had no or little increased LC risk (RR = 1.10, 95% CI = 0.94-1.30). Because the increased incidence of LC was chiefly observed in small cell and squamous cell lung carcinomas, primarily within 2 years of asthma diagnosis and because the association was weak among never smokers, we conclude that the association may not reflect a causal effect of asthma on the risk of LC.

UR - https://www.scopus.com/pages/publications/84863279846

U2 - 10.1093/carcin/bgr307

DO - 10.1093/carcin/bgr307

M3 - Article

C2 - 22198214

AN - SCOPUS:84863279846

SN - 0143-3334

VL - 33

SP - 587

EP - 597

JO - Carcinogenesis

JF - Carcinogenesis

IS - 3

ER -

Asthma and lung cancer risk: A systematic investigation by the international lung cancer consortium

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