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Asymmetric addition of allyltrimethylsilane to (-)-menthyl pyruvate and phenylglyoxylate

  • Sagami Chemical Research Institute

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

The reaction of allyltrimethylsilane with α-keto esters in the presence of titanium tetrachloride afforded a γδ-unsaturated α-hydroxyvalerate in high yield, which with chiral α-keto esters in asymmetric synthesis gave 16-55% enantiomeric excess product.

Original languageEnglish
Pages (from-to)927-928
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number22
DOIs
StatePublished - 1976

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