Asymmetric synthesis of dipeptides by means of homogeneous hydrogenation catalyzed by chiral rhodium complexes

Iwao Ojima; Tadashi Suzuki

doi:10.1016/S0040-4039(00)71381-5

Asymmetric synthesis of dipeptides by means of homogeneous hydrogenation catalyzed by chiral rhodium complexes

Iwao Ojima
, Tadashi Suzuki

Chemistry

Sagami Chemical Research Institute

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Asymmetric hydrogenation of dehydrodipeptides, α-acylaminocinnamoyl-(S)-amino esters, catalyzed by rhodium complexes with chiral diphosphines gave either (R)-N-acylphenylalanyl-(S)-amino esters or (S)-N-acylphenylalanyl-(S)-amino esters with high diastereomeric purity up to 98-99% on using proper chiral ligands.

Original language	English
Pages (from-to)	1239-1242
Number of pages	4
Journal	Tetrahedron Letters
Volume	21
Issue number	13
DOIs	https://doi.org/10.1016/S0040-4039(00)71381-5
State	Published - 1980

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title = "Asymmetric synthesis of dipeptides by means of homogeneous hydrogenation catalyzed by chiral rhodium complexes",

abstract = "Asymmetric hydrogenation of dehydrodipeptides, α-acylaminocinnamoyl-(S)-amino esters, catalyzed by rhodium complexes with chiral diphosphines gave either (R)-N-acylphenylalanyl-(S)-amino esters or (S)-N-acylphenylalanyl-(S)-amino esters with high diastereomeric purity up to 98-99\% on using proper chiral ligands.",

author = "Iwao Ojima and Tadashi Suzuki",

year = "1980",

doi = "10.1016/S0040-4039(00)71381-5",

language = "English",

volume = "21",

pages = "1239--1242",

journal = "Tetrahedron Letters",

issn = "0040-4039",

number = "13",

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TY - JOUR

T1 - Asymmetric synthesis of dipeptides by means of homogeneous hydrogenation catalyzed by chiral rhodium complexes

AU - Ojima, Iwao

AU - Suzuki, Tadashi

PY - 1980

Y1 - 1980

N2 - Asymmetric hydrogenation of dehydrodipeptides, α-acylaminocinnamoyl-(S)-amino esters, catalyzed by rhodium complexes with chiral diphosphines gave either (R)-N-acylphenylalanyl-(S)-amino esters or (S)-N-acylphenylalanyl-(S)-amino esters with high diastereomeric purity up to 98-99% on using proper chiral ligands.

AB - Asymmetric hydrogenation of dehydrodipeptides, α-acylaminocinnamoyl-(S)-amino esters, catalyzed by rhodium complexes with chiral diphosphines gave either (R)-N-acylphenylalanyl-(S)-amino esters or (S)-N-acylphenylalanyl-(S)-amino esters with high diastereomeric purity up to 98-99% on using proper chiral ligands.

UR - https://www.scopus.com/pages/publications/0001425818

U2 - 10.1016/S0040-4039(00)71381-5

DO - 10.1016/S0040-4039(00)71381-5

M3 - Article

AN - SCOPUS:0001425818

SN - 0040-4039

VL - 21

SP - 1239

EP - 1242

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 13

ER -

Asymmetric synthesis of dipeptides by means of homogeneous hydrogenation catalyzed by chiral rhodium complexes

Abstract

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